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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Phosphoinositides II: The Diverse Biological Functions (Paperback, 2012 ed.)
Loot Price: R5,721
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Phosphoinositides II: The Diverse Biological Functions (Paperback, 2012 ed.)
Series: Subcellular Biochemistry, 59
Expected to ship within 10 - 15 working days
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Phosphoinositides play a major role in cellular signaling and
membrane organization. During the last three decades we have
learned that enzymes turning over phosphoinositides control vital
physiological processes and are involved in the initiation and
progression of cancer, inflammation, neurodegenerative,
cardiovascular, metabolic disease and more. In two volumes, this
book elucidates the crucial mechanisms that control the dynamics of
phosphoinositide conversion. Starting out from
phosphatidylinositol, a chain of lipid kinases collaborates to
generate the oncogenic lipid
phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate
group added, there are specific lipid kinases - and phosphatases to
remove it. Additionally, phospholipases can cleave off the inositol
head group and generate poly-phosphoinositols, which act as soluble
signals in the cytosol. Volume II extends into the role of
phosphoinositides in membrane organization and vesicular traffic.
Endocytosis and exocytosis are modulated by phosphoinositides,
which determine the fate and activity of integral membrane
proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent
flag in the plasma membrane, while phosphatidylinositol-3-phosphate
decorates early endosomes. The Golgi apparatus is rich in
phosphatidylinositol-4-phosphate, stressed cells increase
phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a
phosphoinositide metabolism of its own. Phosphoinositide-dependent
signaling cascades and the spatial organization of distinct
phosphoinositide species are required in organelle function,
fission and fusion, membrane channel regulation, cytoskeletal
rearrangements, adhesion processes, and thus orchestrate complex
cellular responses including growth, proliferation,
differentiation, cell motility, and cell polarization.
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