A woman of intelligence and energy, Lou Henry Hoover's talents benefited a large number of cultural and philanthropic organizations, but her distaste for publicity obscured her many achievements until now. By the time her husband reached the White House in 1929, she had already established herself as a woman with high goals. The first woman to earn a university degree in geology, she collaborated with her husband in the translation of a classic book on mining methods. During World War I, she organized assistance for American travelers stranded in Europe, campaigned on behalf of the Commission for the Relief of Belgium, and set up a boarding house in Washington D.C. for young women working in war-related agencies.

Lou Hoover served as president of the Girl Scouts during its formative years, organized the Women's Division of the National Amateur Athletic Federation to encourage public participation in sports, and raised money for a number of cultural and philanthropic organizations. As First Lady, she redecorated the White House to make it a suitable residence for a head of state, cataloging its furnishings for posterity. She founded a school for underprivileged Appalachian children and ran a private, unpublicized relief network for Americans suffering under the Great Depression. After leaving the White House, she resumed the volunteer work that remained such a treasured part of her life.