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The Serotonin Receptors - From Molecular Pharmacology to Human Therapeutics (Hardcover, 2006 ed.): Bryan L Roth The Serotonin Receptors - From Molecular Pharmacology to Human Therapeutics (Hardcover, 2006 ed.)
Bryan L Roth
R6,018 Discovery Miles 60 180 Ships in 10 - 15 working days

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

The Serotonin Receptors - From Molecular Pharmacology to Human Therapeutics (Paperback, Softcover reprint of hardcover 1st ed.... The Serotonin Receptors - From Molecular Pharmacology to Human Therapeutics (Paperback, Softcover reprint of hardcover 1st ed. 2006)
Bryan L Roth
R5,964 Discovery Miles 59 640 Ships in 10 - 15 working days

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

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