In recent years, parasitologists have learned much about the way in which parasite biochemistry differs from that of free-living organisms. Inside the host, factors such as temperature, oxygen tension, carbon dioxide concentration and pH have important consequences for the biochemistry and physiology of the parasitic organism. Strong selection pressure therefore operates at all stages of a parasite's life cycle. The parasite's adaptational response to this pressure is the subject of this book. Under the headings "The nature of parasite adaptation", "Energy metabolism", "Digestion and uptake of nutrients", "Host immunity and parasite adaptation", "Biochemical adaptation and the magic bullet" and "Biochemical variation in parasites", present knowledge of parasite metabolism and how it reflects adaptation to particular environments is surveyed. The ways in which these adaptations may have developed during their evolution - with reference to the modern evolution of strain variations and the development of resistance to antiparasitic compounds - are explored, together with immunological aspects of the host-parasite relationship and potential metabolic targets for chemotherapy. This book should be of use to all those involved and interested in the biochemistry of parasites and its relation to their evolution, ecology, adaptation and variation. Those aspects of parasite metabolism that are attacked by anti-parasitic drugs are described, making this a useful book for those involved in the pharmaceutical industry. This book should be of interest to parasitologists and comparative biochemists.

This lecture note gives an analysis of electronic structure effects for a new class of molecular solids, i. e. one-dimensional organometal lic systems formed by transition-met. l atoms that are embedded in a matrix of macrocyclic organic ligands. These systems as well as orga nic metals have focused considerable interest due to the potential formation of high-mobility charge carriers. For the present author it is difficult to participate in this restriction on a single physical property (i. e. high electronic conductivities, technical applications, etc. ). The lecture note is hopefully a small contribution to enhance the general understanding of certain electronic properties in organo metallic polymers. Those problems have been considered in the first place that seem to form a theoretical deficit in one specific field of solid-state chemistry. For the reader it will become evident that this contribution is a compromise always guided and limited by boundaries: i) An attempt to present problems to a .chemical. audience which have their roots in solid-state physics. ii) The model calculations are limited by the currently available computational facilities. This .boundary. implies that the compu tational data a e subject to severe theoretical approximations. iii) Theorists have often a strong tendency to identify their numeri cal results and models with physical effects. Also this lecture note is not free of this almost universal trend. Nevertheless the author hopes that this text leads to some insight into a rather modern research field. M. e. B6hm I."

The National Transportation Safety Board (NTSB) has long been concerned about alcohol-impaired driving, which accounts for approximately one-third of all U.S. highway fatalities. In the past several decades, awareness of the dangers of alcohol-impaired driving has increased. Public and private entities focusing on this safety issue have changed social perceptions concerning alcohol-impaired driving; they have also achieved important legislative actions to help reduce it. Due to these efforts, the number of lives lost annually in alcohol-impaired-driver-related crashes declined 53 percent, from 21,113 in 1982 to 9,878 in 2011; and the percentage of highway fatalities resulting from alcohol-involved crashes is down from 48 percent in 1982 to about 31 percent today. In recent years, however, U.S. success in addressing this safety issue has plateaued. This book describes the scope of the impaired driving problem; summarises the efforts of advocacy groups, researchers, law enforcement agencies, traffic safety groups, public health organisations, legislators, and motor vehicle agencies, as well as federal, state, and local governments, to reduce the number of crashes, injuries, and fatalities; examines the effect of alcohol consumption on an individual's ability to operate a motor vehicle and on the risk of being involved in a crash; and evaluates the effectiveness of current and emerging alcohol-impaired driving countermeasures and identifies new approaches and actions needed to reduce and ultimately eliminate alcohol-impaired driving.

The imperative for the exchange of terrorism-related intelligence information among law enforcement and security officials at all levels of government is founded on three propositions. The first is that any terrorist attack in the homeland will necessarily occur in a community within a state or tribal area, and the initial response to it will be by state, local, and tribal emergency responders and law enforcement officials. Second, the plotting and preparation for a terrorist attack within the United States will also occur within local communities. Third, information acquired for one purpose, or under one set of authorities, might provide unique insights when combined, in accordance with applicable laws, with seemingly unrelated information from other sources. This book describes the Nation-wide Sar Initiative (NSI), and the rationale for the sharing of terrorism-related Suspicious Activity Reports (SARs), and how the NSI seeks to achieve this objective.