This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.

This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.

This second edition updates the "WHO Classification of Endocrine Tumours" proposed in 1980 and incorporates many new tumour entities and pertinent concepts that have developed since that time. It is the result of a collaborative effort between 9 pathologists from different countries, in addition to informal contributions and discussions by many other colleagues. In particular, efforts have been made to integrate into the fundamental backbone of the histologic classification a number of prognostic and functional parameters now essential for appropriate diagnosis and clinicopathologic evaluation of endocrine tumours.

This is a histological classification of tumours and tumour-like lesions of the exocrine pancreas which also includes those tu- mours showing a mixture of exocrine and endocrine elements. The classification is based principally on standard microscopic observations, but whenever indicated it incorporates diagnosti- cally valuable immunohistological findings. In addition, the most important immunohistological findings which are helpful in cat- egorizing pancreatic tumours are summarised in Table 1. The major guideline of this classification scheme is the group- ing of the pancreatic exocrine tumours according to their biologi- cal behaviour. Thus, the neoplasms are broadly divided into benign (adenoma) and malignant tumours (carcinoma). How- ever, in recent years we have learned that this division is not a sharp but rather a gradual transition. We therefore added a third group which we call "tumours of uncertain malignant potential" representing a borderline category analogous to that recognized for some ovarian tumours. This group includes mucinous cystic tumour, intraductal papillary-mucinous tumour and solid- pseudopapillary tumour. These neoplasms are defined by the grade of dysplasia and/or potential to become malignant. Mucinous cystic tumours of uncertain malignant potential, for instance, exhibit moderate epithelial dysplasia, but do not show severe dysplasia/carcinoma in situ changes, nor carcinomatous invasion of the cyst wall or the adjacent pancreatic tissue. Solid- pseudopapillary tumour has a benign looking histological ap- pearance, but metastases may occur. Biologically, all these neoplasms are primarily slow-growing lesions and have an excel- lent prognosis when adequately treated by complete resection.

Maria Callas is brought back to life in this unprecedented sequence of photographs (1942-1974) and period newspapers (1947-1960) from her personal collection, organised in albums that fully express her taste and choices. The images and the articles preserved by Maria Callas are often enhanced by autograph annotations revealing the names of the people portrayed alongside her, on special occasions or simply in moments of her everyday life. This volume is thus an ideal album of the Divina's memories, fully respecting the order and the themes she favoured, highlighting the sacrality of her personal objects, her career, and her unbridled passion for fashion and elegance. Text in English and Italian.

Spanish historical adventure about the hunt for a soldier whose actions caused Napoleon's first defeat. In 1808, at the height of Napoleon's campaign against the Spanish, a single military drummer causes the French army to panic and retreat when he uses the Monserrat mountains to echo the sound of his drums. After hearing of his army's humiliating defeat, Napoleon demands the drummer's head, and dispatches an elite band of his most deadly imperial guards to track down the young hero at any cost.

It is 1895. Robert Wallis, would-be poet, bohemian and impoverished dandy, accepts a commission from coffee merchant Samuel Pinker to categorise the different tastes of coffee - and encounters Pinker's free-thinking daughters, Philomenia, Ada and Emily. As romance blossoms with Emily, Robert realises that the Muse and marriage may not be incompatible after all. Sent to Abyssinia to make his fortune in the coffee trade, he becomes obsessed with a negro slave girl, Fikre. He decides to use the money he has saved to buy her from her owner - a decision that will change not only his own life, but the lives of the three Pinker sisters . . .

Laura Patterson is an American exchange student in Rome who, fed up with being inexpertly groped by her young Italian beaus, decides there's only one sure-fire way to find a sensual man: date a chef. Then she meets Tomasso, who's handsome, young - and cooks in the exclusive Templi restaurant. Perfect. Except, unbeknownst to Laura, Tomasso is in fact only a waiter at Templi - it's his shy friend Bruno who is the chef. But Tomasso is the one who knows how to get the girls, and when Laura comes to dinner he persuades Bruno to help him with the charade. It works: the meal is a sensual feast, Laura is utterly seduced and Tomasso falls in lust. But it is Bruno, the real chef who has secretly prepared every dish Laura has eaten, who falls deeply and unrequitedly in love. A delicious tale of Cyrano de Bergerac-style culinary seduction, but with sensual recipes instead of love poems.

Twenty-two-year-old James Gould arrives in Occupied Naples in 1943, where his duties include dissuading Allied soldiers from marrying their beautiful Italian girlfriends, and his diet includes little more than spam fritters and warmed-up rations. The girls of Naples, however, soon arrange for a beautiful young country girl to join his staff as a cook. Under the twin influences of Italian food and Italian passion, James has only just realised that his heart is more important than his orders, when an eruption of Vesuvius sets in motion a series of epic events that will change their lives for ever.