|
Showing 1 - 6 of
6 matches in All Departments
It is well known that estrogen is "somehow" a protective hormone for various age-related disorders. This book provides a solid knowledge of estrogen's neuroprotective activities in the brain with a special emphasis on neurodegenerative disorders such as Alzheimer's Disease. The focus is (1) to describe the biochemical, molecular, and cellular basis of the protective activity of estrogen and (2) to transfer this knowledge into the hospitals by discussing preventive and therapeutic approaches such as estrogen replacement therapy for post-menopausal women. Besides up-to-date information on estrogen and the brain, this book explains in a highly understandable manner molecular and cellular techniques by which basic data have been collected. The reader, which may include the professional specialist as well as the interested non-specialist, will also gain insight into the scientific transfer process of knowledge from basic science to the clinical situation and, therefore "from bench to bed".
Aging represents a physiological and "per se" non-pathological
and multifactorial process involving a set of key genes and
mechanisms being triggered by different endogenous and exogenous
factors. Since aging is a major risk factor in connection with a
variety of human disorders, it is increasingly becoming a central
topic in biochemical and medical research. The plethora of theories
on aging some of which have been discussed for decades are neither
isolated nor contradictory but instead can be connected in a
network of pathways and processes at the cellular and molecular
levels. This book summarizes the most prominent and important
approaches, focusing on telomeres, DNA damage and oxidative stress
as well as on the possible role of nutrition, the interplay between
genes and environment (epigenetics) and intracellular protein
homeostasis and introduces some genes that have actually extended
life spans in animal models. Linking these different determinants
of aging with disease, this volume aims to reveal their multiple
interdependencies. We see that there is no single perfect theory of
aging and that instead it is possible to define what the authors
call the "molecular aging matrix" of the cell. A better knowledge
of its key mechanisms and the mutual connections between its
components will lead to a better understanding of age-associated
disorders such as Alzheimer s disease."
It is well known that estrogen is "somehow a protective hormone for
various age-related disorders. This book provides a solid knowledge
of estrogen s neuroprotective activities in the brain with a
special emphasis on neurodegenerative disorders such as Alzheimer s
Disease. The focus is (1) to describe the biochemical, molecular,
and cellular basis of the protective activity of estrogen and (2)
to transfer this knowledge into the hospitals by discussing
preventive and therapeutic approaches such as estrogen replacement
therapy for post-menopausal women. Besides up-to-date information
on estrogen and the brain, this book explains in a highly
understandable manner molecular and cellular techniques by which
basic data have been collected. The reader, which may include the
professional specialist as well as the interested non-specialist,
will also gain insight into the scientific transfer process of
knowledge from basic science to the clinical situation and
therefore "from bench to bed ."
Dieses Buch fuhrt in die wichtigsten Theorien des Alterns ein; es
konzentriert sich auf Telomere, DNA-Schadigung, oxidativen Stress,
die Rolle der Nahrstoffversorgung bzw. -erkennung, das
Zusammenspiel von Genen und Umwelt (Epigenetik) und die
Proteinhomoeostase und stellt einige Gene vor, die die Lebensdauer
in Modellorganismen zu verandern in der Lage sind. Indem es die
verschiedenen das Altern bestimmenden Faktoren mit Erkrankungen des
Menschen verknupft, sucht das Buch ihre vielfaltigen
Wechselbeziehungen und Abhangigkeiten aufzuzeigen und zu einer
molekularen Matrix des Alterns zusammenzufuhren. Von diesem Buch
werden alle profitieren, die sich einen profunden UEberblick uber
die Mechanismen der Zellalterung und ihre Verknupfung mit
altersassoziierten Erkrankungen des Menschen verschaffen wollen.
This book highlights the key phases and central findings of
Alzheimer’s Disease research since the introduction of the label
‘Alzheimer’s Disease’ in 1910. The author, Christian Behl,
puts dementia research in the context of the respective zeitgeist
and summarizes the paths that have led to the currently available
Alzheimer’s drugs. As the reader is taken through the major
developments in Alzheimer's Disease research, particularly over the
past thirty years, Behl poses critical questions: Why are the exact
causes of Alzheimer's Disease still in the dark, despite all the
immense, worldwide research efforts in academia as well as in the
pharmaceutical industry? Why has the majority of an entire research
field kept focusing on a single hypothesis that establishes the
deposition of the amyloid beta peptide in the brain as the key
trigger of Alzheimer's pathology, even though this concept has
still not been convincingly proven in the clinics? Are there other
hypotheses that might explain the pathogenesis of this complex
brain disease, and if so, why were these perspectives not
adequately followed? In this book, Behl tries to answer these
questions. Starting with the historical background, the author
illustrates the long and arduous research journey, its numerous
setbacks, and the many alternative explanations for the disease,
which have started gaining increasing attention and acceptance in
the Alzheimer’s research community only more recently.Â
With his deep dive into the history and progression of this
research, including the most recent developments, Behl explains why
he believes that it is high time to promote a paradigm shift in
Alzheimer’s Disease research. The book is written for all
researchers in the fields of neurobiology and neurodegeneration, as
well as other biomedical fields, who would like to gain a broad and
beyond the surface insight into (the key developments of) one of
the most promoted research fields of our time. With its extensive
literature references and over 100 illustrations, the book is also
attractive for students and interested lay persons. Elaborating on
all the different aspects and research approaches of this research
field, the author aims to convince the reader that the underlying
causes of Alzheimer’s Disease may be much more complex than
previously thought and that this must be considered for future
research directions. While he hopes that the Alzheimer’s research
community is finally ready to shed its ‘amyloid-straitjacket’
that has hampered progress for too long, he is also convinced that
a much-needed paradigm shift can guide future Alzheimer’s Disease
research and provide a new and broader perspective on this
age-dependent brain disease.
|
|