The uniqueness of human architecture is based on interlinkages of the regulatory systems -neural, endocrine, immune, genetic- but the molecular mechanisms underlying this network are still incompletely understood. The endogenous indolergic system is considered as a protein-neuro-humoral-endocrine informational network resulted from the chemical and biological structure of some endogenous biomolecules with indole structure such as tryptophan, serotonin and melatonin. The endogenous privileged structures, such as the indole nucleus, can be used to develop active biological/therapeutic medical compounds, viable, safe and with low toxicity (endogenous-like). The book "Tryptophan, serotonin, melatonin- The spectacular triad" avails the latest data regarding the biochemical and pathophysiological impacts of tryptophan, serotonin and melatonin, the main indolic endogenous compounds, along with an exhaustive research upon medicines with indolic nucleus and the establishment of a complete database with indolic molecules introduced in therapy, medicines that have demonstrated the effectiveness in time and also the therapeutic safety.