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Emerging evidence indicates that the Gadd45 family of genes play a
unique and critical role as sensors of stress, including genotoxic,
physiological and oncogenic stress. The stress response Gadd45
family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr.
Liebermann and other researchers, encode for small (18 kd)
nuclear/cytoplasmic proteins). These genes are rapidly induced by a
wide variety of endogenous and exogenous stress stimuli. In spite
of marked similarities, Gadd45 genes are regulated differently
& exhibit functional diversity. Gadd45 are implicated in cell
cycle arrest, DNA demethylation & repair, apoptosis, cell
survival, genomic stability, inflammation, & in response to
physiological and oncogenic stress. Functions of Gadd45 genes are
mediated by protein-protein interactions that modulate
structure/function of other cellular proteins implicated in cell
cycle regulation and the response of cells to stress; these
interactions vary depending upon the biological setting including
cell type, developmental stage and stress/stimulus. Protein
partners include cdc2/cyclinB1, p21, the p38/JNK stress induced
kinase pathways, and PCNA/histones. The purpose of this book is to
provide a comprehensive picture of the unique global role Gadd45
genes play as stress sensors & the molecular pathways involved.
This second edition is fully updated throughout and covers the
emerging evidence that indicates that the Gadd45 family of proteins
plays a unique and critical role as sensors of stress, including
genotoxic, physiological, and oncogenic stress. It sheds
light on the complex cellular stress response, encompassing myriad
molecular pathways with a plethora of regulators and effectors. The
GADD45 stress response genes encode small (18 kd)
nuclear/cytoplasmic proteins. These genes are rapidly
induced by a wide variety of endogenous and exogenous stress
stimuli. Despite marked similarities, Gadd45 genes are regulated
differentially and exhibit functional diversity. Gadd45
proteins respond to physiological and oncogenic stress, and are
implicated in cell cycle arrest, DNA demethylation and repair,
apoptosis, cell survival, genomic stability, and inflammation. The
purpose of this book is to provide a comprehensive overview of the
unique global role that Gadd45 proteins play as stress sensors and
the molecular pathways involved.
This second edition is fully updated throughout and covers the
emerging evidence that indicates that the Gadd45 family of proteins
plays a unique and critical role as sensors of stress, including
genotoxic, physiological, and oncogenic stress. It sheds light on
the complex cellular stress response, encompassing myriad molecular
pathways with a plethora of regulators and effectors. The GADD45
stress response genes encode small (18 kd) nuclear/cytoplasmic
proteins. These genes are rapidly induced by a wide variety of
endogenous and exogenous stress stimuli. Despite marked
similarities, Gadd45 genes are regulated differentially and exhibit
functional diversity. Gadd45 proteins respond to physiological and
oncogenic stress, and are implicated in cell cycle arrest, DNA
demethylation and repair, apoptosis, cell survival, genomic
stability, and inflammation. The purpose of this book is to provide
a comprehensive overview of the unique global role that Gadd45
proteins play as stress sensors and the molecular pathways
involved.
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