Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy.

This book - the first in the English language to contain an exhaustive collection of Japanese baseball data - presents basic statistical information and listings for every Japanese professional baseball season from 1936 through 1997. The first part contains yearly breakdowns of team standings; qualifiers for batting and earned run championships; leaders in home runs, runs batted in, wins and strikeouts; all-star game results; Japan Series results; Best Nine selections; Gold Glove selections; and award winners. Sections on career records and single-season records are provided in the second part of this work. Appendices list no-hit, no-run games, Japanese Hall of Famers, and records of foreign tours of Japan by professional teams.