This volume describes recent research in the field of metalloproteinas es, in particular their participation in autoimmune diseases such as r heumatoid arthritis. The work updates current progress in matrix metal loproteinase research, reviewing the latest developments in metallopro teinase inhibitor design and the current status of clinical candidates . It elucidates the structural relationships between different members of the MMP family and provides insight into the contributions of diff erent metalloproteinases to normal and pathological processes. Special emphasis is given to the potential of adamlysins as therapeutic targe ts. This volume is intended not only for those active in research into metalloproteinases but also for those with an interest in inflammator y diseases. Thus it addresses both academic and industrial researchers .

In an age of intense economic competition and continual change, the ability to learn is a key factor in survival and prosperity. This book examines the changing interaction of the world economy, Britain 's prospects for prosperity, the connections between different kinds of work and the learning that support them. Focusing on specific areas where changed attitudes and ways of working are long overdue, the authors show the need for a better balance between formal provision in schools, colleges and within employment, and less tangible informal learning at home and in the workplace. These, in turn, open up issues of the curriculum (especially in the formative later years in schools and colleges), guidance for education and work and the qualifications structure.

The essays in Moving Modernisms: Motion, Technology, and Modernity, written by renowned international scholars, open up the many dimensions and arenas of modernist movement and movements: spatial, geographical and political: affective and physiological; temporal and epochal; technological, locomotive and metropolitan; aesthetic and representational. Individual essays explore modernism's complex geographies, focusing on Anglo-European modernisms while also engaging with the debates engendered by recent models of world literatures and global modernisms. From questions of space and place, the volume moves to a focus on movement and motion, with topics ranging from modernity and bodily energies to issues of scale and quantity. The final chapters in the volume examine modernist film and the moving image, and travel and transport in the modern metropolis. 'Movement is reality itself', the philosopher Henri Bergson wrote: the original and illuminating essays in Moving Modernisms point in new ways to the realities, and the fantasies, of movement in modernist culture.

This innovative book comprises nine essays from leading scholars which investigate the relationship between fiction, censorship and the legal construction of obscenity in Britain between 1850 and the present day. Each of the chapters focuses on a distinct historical period and each has something new to say about the literary works it spotlights. Overall, the volume fundamentally refreshes our understanding of the way texts had to negotiate the moral and legal minefields of public reception. The book is original in the historical period it covers, starting in 1850 and bringing debates about fiction, obscenity and censorship up to the present day. The history that is uncovered reveals the different ways in which censorship functioned and continues to function, with considerations of Statutory definitions of Obscenity alongside the activities of non-government organisations such as the anti-vice societies, circulating libraries, publishers, printers and commentators. The essays in this book argue that the vigour with which novels were hunted down by the prowling prudes of the book's title encouraged some writers to explore sexual, excremental and moral obscenities with even more determination. Bringing such debates up to date, the book considers the ongoing impact of censorship on fiction and the current state of critical thinking about the status and freedom of literature. Given contemporary debates about the limits on freedom of speech in liberal, secular societies, the interrogation of these questions is both timely and necessary.

'I shall never forget the day I wrote "The Mark on the Wall" - all in a flash, as if flying, after being kept stone breaking for months. "The Unwritten Novel" was the great discovery, however. That - again in one second - showed me how I could embody all my deposit of experience in a shape that fitted it... I saw, branching out of the tunnel I made, when I discovered that method of approach, Jacob's Room, Mrs Dalloway etc - How I trembled with excitement.' The thrill Woolf got from these stories is readily apparent to the reader. She wrote them in defiance of convention, with a heady feeling of liberation and with a clear sense that she was breaking new ground. Indeed, if she had not made her bold and experimental forays into the short story in the period leading up to the publication of Jacob's Room (1922), it seems certain that her arrival as a great modernist novelist would have been delayed. Quirky, unrestrained, disturbing and surprising, many of these stories, particularly the early ones, are essential to an understanding of Woolf's development as a writer. She thought some of her short fiction might be 'unprintable' but, happily, she was mistaken. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more.

This new collection of essays, each one by a recognized expert, both brings Forster studies up to date and provides lively and innovative readings of every aspect of his wide-ranging career. It includes substantial chapters dedicated to his two major novels, Howards End and A Passage to India, and further chapters focus on A Room With a View and Maurice. Forster's connections with the values of Bloomsbury and the lure of Greece and Italy in his work are assessed, as is his vexed relationship with Modernism. Other essays investigate his role as a literary critic, the status of his work within the genres of the novel and the short story, his treatment of sexuality and his attitude to and representation of women. This is the most comprehensive study of Forster's work to be published for many years, providing an invaluable source of comment on and insight into his writings.

Winner of the Journal of the History of Ideas's Morris D. Forkosch prize This book traces the development thought about God and the relationship between God's being and activity from Aristotle, through the pagan Neoplatonists, to thinkers such as Augustine, Boethius, and Aquinas (in the West) and Dionysius the Areopagite, Maximus the Confessor, and Gregory Palamas (in the East). The resulst is a comparative history of philosophical thought in the two halves of Christendom, providing a philosophical backdrop to the schism between the Eastern and Western churches.

In an age of intense economic competition and continual change, the ability to learn is a key factor in survival and prosperity. This book examines the changing interaction of the world economy, Britain s prospects for prosperity, the connections between different kinds of work and the learning that support them. Focusing on specific areas where changed attitudes and ways of working are long overdue, the authors show the need for a better balance between formal provision in schools, colleges and within employment, and less tangible informal learning at home and in the workplace. These, in turn, open up issues of the curriculum (especially in the formative later years in schools and colleges), guidance for education and work and the qualifications structure.

'A good essay must draw its curtain round us, but it must be a curtain that shuts us in, not out.' According to Virginia Woolf, the goal of the essay 'is simply that it should give pleasure...It should lay us under a spell with its first word, and we should only wake, refreshed, with its last.' One of the best practitioners of the art she analysed so rewardingly, Woolf displayed her essay-writing skills across a wide range of subjects, with all the craftsmanship, substance, and rich allure of her novels. This selection brings together thirty of her best essays, including the famous 'Mr Bennett and Mrs Brown', a clarion call for modern fiction. She discusses the arts of writing and of reading, and the particular role and reputation of women writers. She writes movingly about her father and the art of biography, and of the London scene in the early decades of the twentieth century. Overall, these pieces are as indispensable to an understanding of this great writer as they are enchanting in their own right. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more.

This volume describes recent research in the field of metalloproteinases (a family of enzymes that can catalyze tissue degradation), in particular their participation in autoimmune diseases such as rheumatoid arthritis, reviewing the latest developments in metalloproteinase inhibitor design and the current status of clinical candidates. This volume is intended not only for those active in research into metalloproteinases but also for those with an interest in inflammatory diseases. Thus it addresses both academic and industrial researchers.

'The ponderous woman looked through the pattern of falling words at the flowers standing cool, firm, and upright in the earth, with a curious expression. . .So heavy the woman came to a standstill opposite the oval shaped flowerbed, and ceased even to pretend to listen to what the other woman was saying.' Virginia Woolf's short fiction has long been acknowledged as the place where she tried out some of her more experimental techniques before adopting and adapting them for use in her novel-length works. While this is certainly true, it is also the case that these short pieces are now increasingly being recognized as important works of art in their own right, rather than simply flights of experimental fancy awaiting their full actualization in the novel form. This new edition edited by Bryony Randall emphasises the startling variety in Woolf's experimentation during the most productive period of short fiction writing in Woolf's life, the late 1910s through to the end of the 1920s. It draws readers' attention to the deep political engagements evident across the range of her work and on the recent burgeoning of work in modernist print culture to set out the importance of the material context of these works' initial publication and reception.

For over a hundred years the Pacific island of Pala has been the scene of a unique experiment in civilisation. Its inhabitants live in a society where western science has been brought together with Eastern philosophy to create a paradise on earth. When cynical journalist, Will Farnaby, arrives to research potential oil reserves on Pala, he quickly falls in love with the way of life on the island. Soon the need to complete his mission becomes an intolerable burden and he must make a difficult choice. In counterpoint to Brave New World and Ape and Essence, in Island Huxley gives us his vision of utopia. WITH A BIOGRAPHICAL INTRODUCTION BY DAVID BRADSHAW

'I, who would wish to feel close over me the protective waves of the ordinary, catch with the tail of my eye some far horizon.' Intensely visionary yet absorbed with the everyday; experimental, daring and challenging, The Waves is regarded by many as Virginia Woolf's greatest achievement. It follows a set of six friends from childhood to middle age as they experience the world around them and explore who they are and what it means to be alive. As the contours of their lives are revealed, a unique novel is slowly unveiled. Enfolded within Woolf's lyrical and mysterious language, the mundane takes on a startling new significance while distant pasts are no less in play than the clamorous sounds and kaleidoscopic sights of the modern city. Yet precisely where the alluringly enigmatic pages of The Waves are leading, and what deeper meanings are held within its undulant chapters and shimmering interludes, are questions that have never ceased to enthral readers and critics alike. In this new edition David Bradshaw considers the spellbinding oddness and originality of The Waves, helping the reader to negotiate a way though this most poetic and haunting of novels. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more.

`New eyes were opened in her soul. She saw a strange creature from another world, in him. It was as if she were enchanted, and everything were metamorphosed.' In Women in Love (1920), Ursula and Gudrun Brangwen, who first appeared in Lawrence's earlier novel, The Rainbow, take centre stage as Lawrence explores their growth and development in their relationships with two powerful men, Rupert Birkin and his friend Gerald Crich. A novel of regeneration and dark, destructive human passion, Women in Love reflects the impact on Lawrence of the First World War in the potential both for annihilation and salvation of the self. Quintessentially modernist, Women is Love is one of Lawrence's most extraordinary, innovative and unsettling works. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more.

WITH AN INTRODUCTION BY DAVID BRADSHAW Anthony Beavis is a man inclined to recoil from life. His past is haunted by the death of his best friend Brian and by his entanglement with the cynical and manipulative Mary Amberley. Realising that his determined detachment from the world has been motivated not by intellectual honesty but by moral cowardice, Anthony attempts to find a new way to live. Eyeless in Gaza is considered by many to be Huxley's definitive work of fiction.

A gripping biography by the author of Brave New World The life of Father Joseph, Cardinal Richelieu's aide, was a shocking paradox. After spending his days directing operations on the battlefield, Father Joseph would pass the night in prayer, or in composing spiritual guidance for the nuns in his care. He was an aspirant to sainthood and a practising mystic, yet his ruthless exercise of power succeeded in prolonging the unspeakable horrors of the Thirty Years' War. In his masterful biography, Huxley explores how an intensely religious man could lead such a life and how he reconciled the seemingly opposing moral systems of religion and politics.

Same Sex is the most comprehensive anthology on homosexuality available. It goes beyond other classroom readers to explore historical conceptions of homosexuality, homosexual identity, and a variety of public policy issues, ranging from gay marriage to outing to military service. It also examines the issues from ethical, religious, and scientific perspectives. While the authors represent a wide range of opinions on homosexuality, the anthology cuts through the emotional fervor surrounding homosexuality to offer reasoned, lucid discussion of the issues.

In his 1932 classic dystopian novel, Brave New World, Aldous Huxley depicted a future society in thrall to science and regulated by sophisticated methods of social control. Nearly thirty years later in Brave New World Revisited, Huxley checked the progress of his prophecies against reality and argued that many of his fictional fantasies had grown uncomfortably close to the truth. Brave New World Revisited includes Huxley's views on overpopulation, propaganda, advertising and government control, and is an urgent and powerful appeal for the defence of individualism still alarmingly relevant today.

Ford Madox Ford's extraordinary novel of passion and betrayal, The Good Soldier, is edited with an introduction by David Bradshaw in Penguin Classics. The Dowells, a wealthy American couple, have been close friends with the Ashburnhams for years. Edward Ashburnham, a first-rate soldier, seems to be the perfect English gentleman, and Leonora his perfect wife, but beneath the surface their marriage seethes with unhappiness and deception. Our only window on the strange tangle of events surrounding Edward is provided by John Dowell, the husband he deceives. Gradually Dowell unfolds a devastating story, in which everyone's honesty is in doubt. The Good Soldier is a masterpiece of narrative skill and emotional depth. David Bradshaw's introduction discusses John Dowell as the classic unreliable narrator and as English literature's most fascinating enigma, and shows how Ford Madox Ford's unconventional narrative structure makes The Good Soldier a modernist masterwork. Ford Madox Ford (1873-1939), born in Surrey and educated in England, Germany and France, changed his original surname, Hueffer, in 1919, after having served with the British army in World War I. As well as founding both the English Review and the Transatlantic Review, home to such writers as James Joyce, Ezra Pound and Gertrude Stein, Ford was the author of more than sixty works including novels, poems, criticism, travel writing and reminiscences. The Good Soldier (1915) is considered his masterpiece. If you enjoyed The Good Soldier, you might like Ford's Parade's End, also available in Penguin Classics, and now the subject of a major new BBC/HBO television miniseries. 'A masterpiece' Julian Barnes, Booker Prize-winning author of The Sense of an Ending 'I don't know how many times in nearly forty years I have come back to this novel' Graham Greene

'Fear no more the heat of the sun.' Mrs Dalloway, Virginia Woolf's fourth novel, offers the reader an impression of a single June day in London in 1923. Clarissa Dalloway, the wife of a Conservative member of parliament, is preparing to give an evening party, while the shell-shocked Septimus Warren Smith hears the birds in Regent's Park chattering in Greek. There seems to be nothing, except perhaps London, to link Clarissa and Septimus. She is middle-aged and prosperous, with a sheltered happy life behind her; Smith is young, poor, and driven to hatred of himself and the whole human race. Yet both share a terror of existence, and sense the pull of death. The world of Mrs Dalloway is evoked in Woolf's famous stream of consciousness style, in a lyrical and haunting language which has made this, from its publication in 1925, one of her most popular novels. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more.

In a renovated Italian palace set above the blue of the sea, the Junoesque figure of Mrs Aldwinkle moves among her guests. These include a poet who earns his living editing The Rabbit Fancier's Gazette; a popular novelist who records every detail of her affair with another guest as future literary material; an aging philosopher who pursues a wealthy yet mentally-disabled heiress and a pair of naive and charming young lovers. Deliciously satirical, Those Barren Leaves bites the hands of those who dare to posture or feign sophistication and is as comically fresh today as when it was first published.