Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden: Discovery and Development discusses foundational reactions in organic chemistry and their major protagonists, contributions to synthesis, and history. Hofmann, Zaitsev, and Markovnikov are introduced, along with their major discoveries and contributions to organic chemistry. The history of controversies around Markovnikov's Rule are addressed. The book introduces Walden's original demonstration of configuration inversion, then discusses bimolecular elimination reactions, regioselective addition reactions, regiospecific alkene synthesis, and the development of modern reactions with configuration inversion. With its unique perspective, focus, and comprehensive coverage, this book belongs on the shelf of every organic chemist.

The organic chemists of Russia during the pre-revolutionary period included some of the most creative and talented chemists of the nineteenth and early twentieth centuries. Indeed, this is attested by the number of reactions and empirical rules bearing their names. This volume is of interest for both historians of chemistry and organic chemists wishing to discover more about the historical development of their discipline in Russia. From the founding of the Russian Academy of Sciences by Peter the Great in 1725 to the early years of the nineteenth century, Russian organic chemistry was largely in the hands of foreign scientists. However, the Russification of organic chemistry in Russia had begun before the middle of the nineteenth century, and reached its zenith during the last half of the same century, by which time vibrant schools of chemistry had arisen in the eastern city of Kazan', at Moscow and at St. Petersburg. By the end of the century, the Chairs of organic chemistry at universities throughout the Russian empire were occupied by Russian chemists, almost half of them trained at Kazan'. This volume discusses the contributions of these organic chemists which include: the structural theory of organic chemistry, empirical rules for addition and elimination, reactions involving carbon nucleophiles, such as the aldol reaction and alcohol synthesis using organozinc nucleophiles, the discovery of sulfoxides and sulfonium salts, and a range of important redox reactions.

The administrative state is the nexus of American policy making in the postwar period. The vague and sometimes conflicting policy mandates of Congress, the president, and courts are translated into real public policy in the bureaucracy. As the role of the national government has expanded, the national legislature and executive have increasingly delegated authority to administrative agencies to make fundamental policy decisions. How this administrative state is designed, its coherence, its responsiveness, and its efficacy determine, in Robert Dahl s phrase, who gets what, when, and how. This study of agency design, thus, has implications for the study of politics in many areas.
The structure of bureaucracies can determine the degree to which political actors can change the direction of agency policy. Politicians frequently attempt to lock their policy preferences into place through insulating structures that are mandated by statute or executive decree. This insulation of public bureaucracies such as the National Transportation Safety Board, the Federal Election Commission, and the National Nuclear Security Administration, is essential to understanding both administrative policy outputs and executive-legislative politics in the United States.
This book explains why, when, and how political actors create administrative agencies in such a way as to insulate them from political control, particularly presidential control.
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The administrative state is the nexus of American policy making in the postwar period. The vague and sometimes conflicting policy mandates of Congress, the president, and courts are translated into real public policy in the bureaucracy. As the role of the national government has expanded, the national legislature and executive have increasingly delegated authority to administrative agencies to make fundamental policy decisions. How this administrative state is designed, its coherence, its responsiveness, and its efficacy determine, in Robert Dahl's phrase, "who gets what, when, and how." This study of agency design, thus, has implications for the study of politics in many areas. The structure of bureaucracies can determine the degree to which political actors can change the direction of agency policy. Politicians frequently attempt to lock their policy preferences into place through insulating structures that are mandated by statute or executive decree. This insulation of public bureaucracies such as the National Transportation Safety Board, the Federal Election Commission, and the National Nuclear Security Administration, is essential to understanding both administrative policy outputs and executive-legislative politics in the United States. This book explains why, when, and how political actors create administrative agencies in such a way as to insulate them from political control, particularly presidential control.

"In this impressive new book, David Lewis tells us why presidents often--but not always--rely on political appointees to staff bureaucracies. With its mixture of insightful theory, careful statistical tests, and a deep understanding of how bureaucracies work, this book represents the scientific study of bureaucracy at its finest."--Charles Shipan, coauthor of "Deliberate Discretion?"

"Political science is sadly currently producing few scholars concerned with improving the management of the federal government. David Lewis is a striking exception. This well-argued, methodologically rigorous study of the baleful impact of the increasing number of political appointees in agencies on government performance makes an important contribution both to the academic literature and to an important practical debate about governance."--Steve Kelman, Harvard University

"This book is an important contribution to our understanding of how power works in the executive branch of government. Lewis is careful in his arguments, precise with his data, and logical in his presentation. He has collected and analyzed impressive evidence to explain the techniques of politicization and their consequences. This book is the most complete analysis of presidential personnel policy available."--James P. Pfiffner, George Mason University

"This is a remarkable work. Lewis challenges some of the basic assumptions that have been made in past research on this subject. He demonstrates that the increase in politicization occurred until 1980 and then flattened out. Lewis finds that while politicization continues, it is not trending upward as past research suggests. All presidents do not have the same incentives when itcomes to politicizing the bureaucracy."--Richard W. Waterman, University of Kentucky

The Wolff-Kishner Reduction and Related Reactions: Discovery and Development offers a detailed discussion of this reaction, its discoverers, and its development since its discovery. Derivative name reactions-including the Wharton and Shapiro reactions-are also discussed. The book is illustrated with examples from literature and corresponding references to the primary literature to aid further reading. It provides a comprehensive review of the century of chemistry that allows the reader to follow the development of this important synthetic reaction. In addition, it provides biographical details on the chemists who discovered and developed the reaction, thus adding a human dimension to the discussion.