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Mitosis: Methods and Protocols provides state-of-the-art overviews
on the most important approaches currently used in mitosis research
spanning from the analysis of single molecules in isolation to
their utilization within the complex environment of the cell. The
volume is divided into four parts, each focused on methods
pertaining to distinct aspects of mitosis research. Part I presents
approaches for visualizing and analyzing the dynamic behaviors of
the spindle apparatus, the microtubule based machine that drives
chromosome segregation. Part II focuses more generally on methods
for studying and manipulating the microtubule cytoskeleton in cells
and complex cell free extracts. Part III provides state of the art
biophysical and high resolution microscopy approaches for assessing
complex interactions between microtubules and
microtubule-associated proteins in isolation as well as microtubule
structure in cells. Part IV provides methods for studying the
effects of cell shape on cell division and methods for quantifying
aneuploidy (aberrant chromosome number) which frequently results
from mitotic defects and has been linked to human maladies ranging
from birth defects to cancer. Written in the highly successful
Methods in Molecular Biology series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols and key tips on troubleshooting and avoiding
known pitfalls. Authoritative and practical, Mitosis: Methods and
Protocols seeks to provide diverse methods and new techniques to
address new or old questions related to the mechanisms of mitosis.
Mitosis: Methods and Protocols provides state-of-the-art overviews
on the most important approaches currently used in mitosis research
spanning from the analysis of single molecules in isolation to
their utilization within the complex environment of the cell. The
volume is divided into four parts, each focused on methods
pertaining to distinct aspects of mitosis research. Part I presents
approaches for visualizing and analyzing the dynamic behaviors of
the spindle apparatus, the microtubule based machine that drives
chromosome segregation. Part II focuses more generally on methods
for studying and manipulating the microtubule cytoskeleton in cells
and complex cell free extracts. Part III provides state of the art
biophysical and high resolution microscopy approaches for assessing
complex interactions between microtubules and
microtubule-associated proteins in isolation as well as microtubule
structure in cells. Part IV provides methods for studying the
effects of cell shape on cell division and methods for quantifying
aneuploidy (aberrant chromosome number) which frequently results
from mitotic defects and has been linked to human maladies ranging
from birth defects to cancer. Written in the highly successful
Methods in Molecular Biology series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols and key tips on troubleshooting and avoiding
known pitfalls. Authoritative and practical, Mitosis: Methods and
Protocols seeks to provide diverse methods and new techniques to
address new or old questions related to the mechanisms of mitosis.
"Fresh and insightful cases." -Dr. Patricia Mitchell, University of
San Francisco The Ivey Casebooks Series is a co-publishing
partnership between SAGE Publications and the Richard Ivey School
of Business at The University of Western Ontario. Due to their
popularity in more than 60 countries, approximately 200 new cases
are added to the Ivey School of Business library each year. Each of
the casebooks comes equipped with Instructor's Resources on CD-ROM.
These affordable collections will not only help students connect to
real-world situations, but will benefit corporations seeking
continued education in the field as well. Cases in Business Ethics
provides the opportunity for students not only to discuss the
application of ethical theories in managerial situations, but also
to apply judgment and make decisions in a real-world context. This
collection of cases focuses on business decision- making, and
includes both short and long, more complex cases that highlight the
practicalities of business practice and ethical theory. A
beneficial feature of Cases in Business Ethics is the variety of
ways in which the cases can be organized to fit the course
curriculum. The instructor's resources on CD-ROM includes detailed
6-10 page casenotes for each case, preparation questions for
students to review before class, discussion questions, and
suggested further readings. The IVEY Casebook Series Cases in
Business Ethics Cases in Entrepreneurship Cases in Gender &
Diversity in Organizations Cases in Operations Management Cases in
Organizational Behavior Cases in the Environment of Business Cases
in Alliance Management Mergers and Acquitisions: Text and Cases
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