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Mitosis - Methods and Protocols (Hardcover, 2014 ed.) Loot Price: R2,917
Discovery Miles 29 170
You Save: R597 (17%)
Mitosis - Methods and Protocols (Hardcover, 2014 ed.): David J. Sharp

Mitosis - Methods and Protocols (Hardcover, 2014 ed.)

David J. Sharp

Series: Methods in Molecular Biology, 1136

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List price R3,514 Loot Price R2,917 Discovery Miles 29 170 | Repayment Terms: R267 pm x 12* You Save R597 (17%)

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Mitosis: Methods and Protocols provides state-of-the-art overviews on the most important approaches currently used in mitosis research spanning from the analysis of single molecules in isolation to their utilization within the complex environment of the cell. The volume is divided into four parts, each focused on methods pertaining to distinct aspects of mitosis research. Part I presents approaches for visualizing and analyzing the dynamic behaviors of the spindle apparatus, the microtubule based machine that drives chromosome segregation. Part II focuses more generally on methods for studying and manipulating the microtubule cytoskeleton in cells and complex cell free extracts. Part III provides state of the art biophysical and high resolution microscopy approaches for assessing complex interactions between microtubules and microtubule-associated proteins in isolation as well as microtubule structure in cells. Part IV provides methods for studying the effects of cell shape on cell division and methods for quantifying aneuploidy (aberrant chromosome number) which frequently results from mitotic defects and has been linked to human maladies ranging from birth defects to cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mitosis: Methods and Protocols seeks to provide diverse methods and new techniques to address new or old questions related to the mechanisms of mitosis.


Imprint: HumanaPress
Country of origin: United States
Series: Methods in Molecular Biology, 1136
Release date: March 2014
First published: 2014
Editors: David J. Sharp
Dimensions: 254 x 178 x 17mm (L x W x T)
Format: Hardcover
Pages: 308
Edition: 2014 ed.
ISBN-13: 978-1-4939-0328-3
Categories: Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
LSN: 1-4939-0328-4
Barcode: 9781493903283

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