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1. Prevention and Early Detection of Lung Cancer - Clinical
Aspects.- 2. Smoking Prevention and Cessation.- 3. Clinical
Pharmacology of Vitamin A and Retinoids.- 4. Early Lung Cancer
Detection.- 5. Molecular Abnormalities in the Sequential
Development of Lung Carcinoma.- 6. Application of In Situ PCR and
In Situ Hybridization to the Characterization of Lung Cancers.- 7.
Tumor Stroma Formation in Lung Cancer.- 8. Tumor Angiogenesis:
Basis for New Prognostic Factors and New Anticancer Therapies.- 9.
Cell Cycle Regulators and Mechanisms of Growth Control Evasion in
Lung Cancer.- 10. Molecular Genetics of Lung Cancer.- 11.
Neuropeptides, Signal Transduction and Small Cell Lung Cancer.- 12.
In Vitro Analysis of Bombesin/Gastrin-Releasing Peptide Receptor
(bb2) Ligand Binding and G-Protein Coupling.- 13. DNA Methylation
Changes in Lung Cancer.- 14. K-ras Mutations as Molecular Markers
of Lung Cancer.- 15. Sheep Lung Adenomatosis: A Model of Virally
Induced Lung Cancer.- 16. Retinoic Acid Receptor ss An Exploration
of its Role in Lung Cancer Suppression and its Potential in Cancer
Prevention.- 17. Cytochrome P450 Polymorphisms: Risk Factors for
Lung Cancer?.- 18. Glutathione S-Transferases and Lung Cancer
Risk.- 19. The p53 Tumor Suppressor Gene in Lung Cancer: From
Molecular to Serological Diagnosis.- 20. Endoscopic Localization of
Preneoplastic Lung Lesions.- 21. Antigen Retrieval Improves hnRNP
A2/B1 Immunohisto-chemical Localization in Premalignant Lesions of
the Lung.- 22. Molecular Pathological Mechanisms in NSCLC and the
Assessment of Individuals with a High Risk of Developing Lung
Cancer.- 23. Chemoprevention of Lung Cancer.- 24. Regional Delivery
of Retinoids: A New Approach to Early Lung Cancer Intervention.-
25. Natural Inhibitors of Carcinogenesis.- 26. Gene Delivery to
Airways.- 27. Lung Cancer Prevention: The Point of View of a Public
Health Epidemiologist.- 28. Biomarkers as Intermediate Endpoints in
Chemoprevention Trials: Biological Basis of Lung Cancer
Prevention.- 29. Biological Tools for Mass Screening.- 30.
Optimization of the Use of Biological Samples for the Prospective
Evaluation of Preneoplastic Lesions.
1. Gene Therapy.- Asthma.- 2. Genetics of Asthma.- 3. Transcription
Factors and Inflammatory Lung Disease.- 4. Regulation of the
Cytokine Gene Cluster on Chromosome 5q.- 5. Cytokine Expression in
Asthma.- 6. ?-Adrenoceptors.- 7. Regulation of Eosinophil
Migration.- 8. Proteinase Allergens of House Dust Mites: Molecular
Biology, Biochemistry and Possible Functional Significance of Their
Enzyme Activity.- Cancer.- 9. Gene Expression in Lung Cancer.- 10.
Gene Therapy for Cancer: Prospects for the Treatment of Lung
Tumours.
This book gives an up-to-date analysis of the epidemiology of
asthma i n children and adults, the role of steroids in asthma
management and n ew and novel asthma therapies. Specific chapters
deal with the epidem iology of asthma mortality and of childhood
asthma, others discuss the advantages and drawbacks of the use of
b2-adenoreceptor agonists, cor ticosteroids, theophylline and new
generation phosphodiesterase inhibi tors in the treatment of
asthma. A new non-invasive method to assess a irway inflammation is
also presented as well as steroid-sparing therap ies in asthma. The
book addresses clinicians and basic scientists wit h an interest in
asthma epidemiology, steroids and future therapies. I t is also of
interest to clinical and no-clinical teachers in academic
disciplines relating to respiratory disease.
1. Application of Transgenic and Gene-Targeted Mice to Dissect
Mechanisms of Lung Disease.- Emphysema.- 2. Models of Genetic
Emphysema: The C57B1/6J Mice and their Mutants: Tight-Skin, Pallid
and Beige Giuseppe Lungarella, Eleonora Cavarra and.- 3.
?1-Antitrypsin Deficiency.- 4. Recombinant SLPI: Emphysema and
Asthma.- 5. Elastase Inhibitors in the Lung: Expression and
Functional Relationships.- 6. Regulation of Neutrophil
Proteinases.- 7. Control of Connective Tissue Genes.- Infection.-
8. Genetic Models of Bacterial Lung Infection.- 9. Genetics of
Bacteria: Role in Pathogenesis of Infection of the Respiratory
Tract.- 10. Polymerase Chain Reaction in the Diagnosis of
Respiratory Tract Infections.- 11. Cystic Fibrosis.- 12.
Respiratory Bacterial Infections in Patients with Cystic Fibrosis:
Pathogenicity and Implications for Serine Proteinase Inhibitor
Therapy.
to Nitric Oxide Biology.- 1. Nitric Oxide Synthesis and Actions.-
2. Reactive Oxygen and Reactive Nitrogen Species in the Lung.- Role
of Endogenous Nitric Oxide in the Lung.- 3. Non-Adrenergic
Non-Cholinergic Neurotransmission in the Airways: Role of Nitric
Oxide.- 4. Localisation of Nitric Oxide Synthases in the Lung.- 5.
Role of Nitric Oxide in the Regulation of Pulmonary Vascular Tone.-
6. Nitric Oxide and Bronchial Hyperresponsiveness.- 7.
Bronchodilator Actions of Nitric Oxide and Related Compounds.- 8.
Role of Nitric Oxide in Airway Inflammation.- Therapeutic Potential
of Inhalded Nitric Oxide and Nitric Oxide Synthase Inhibitors in
Lung Disease.- 9. Nitric Oxide in Exhaled Air: Relevance in
Inflammatory Lung Disease.- 10. Luminal Nitric Oxide in the Upper
Airways: Implications for Local and Distal Sites of Action.- 11.
Inhaled Nitric Oxide as a Therapy for Diseases of the Pulmonary
Vasculature.- 12. Combinded Use of Nitric Oxide and Nitric Oxide
Synthase Inhibitors as a Possible Therapeutic Approach.
Continuing the Respiratory Pharmacology and Pharmacotherapy series,
this volume explores the pathophysiology and therapy of rhinitis.
The volume is introduced by a chapter describing the normal anatomy
and physiology of the nose and sinuses. Against this background the
contributing authors describe and discuss the immunological and
pathological changes which occur in rhinitis. The various causes
and the types of rhinitis - such as allergic, vasomotor, and
infectious - are discussed as are the treatments available
(pharmacotherapy, immunotherapy, surgery). The book concludes with
a description of the animal models of rhinitis which are now
available. This book will be of interest to bench scientists and
clinicians alike.
This commentary discusses Aeschylus' play Agamemnon (458 BC), which
is one of the most popular of the surviving ancient Greek
tragedies, and is the first to be published in English since 1958.
It is designed particularly to help students who are tackling
Aeschylus in the original Greek for the first time, and includes a
reprint of D. L. Page's Oxford Classical Text of the play.
The introduction defines the place of Agamemnon within the Oresteia
trilogy as a whole, and the historical context in which the plays
were produced. It discusses Aeschylus' handling of the traditional
myth and the main ideas which underpin his overall design: such as
the development of justice and the nature of human responsibility;
and it emphasizes how the power of words, seen as ominous
speech-acts which can determine future events, makes a central
contribution to the play's dramatic momentum. Separate sections
explore Aeschylus' use of theatrical resources, the role of the
chorus, and the solo characters. Finally there is an analysis of
Aeschylus' distinctive poetic style and use of imagery, and an
outline of the transmission of the play from 458 BC to the first
printed editions.
Most studies on autonomic innervation of smooth muscle have focused
on the short-term mechanisms involved in neurotransmission in
physiological and pathophysiological conditions. However recent
obser vations of the long-term plasticity of this system, i. e. its
capacity for regeneration and for compensatory change in pattern of
innervation and expression of cotransmitters and receptors in
ageing, following surgery, trauma or in disease, have indicated
that an understanding of the mechanisms involved could influence
the design of therapeutic regimes. There is increasing evidence for
long-term communication between nerves and smooth muscle cells
during development and throughout adult life. To date, the trophic
interactions between nerves and airway musculature have attracted
little interest, consequently, much of the information presented
here is drawn from studies using other smooth muscles. However, the
questions posed about trophic interactions dur ing development
apply as much to airways smooth muscle neuroeffector systems as to
other autonomic neuroeffector systems. These are: i) How do
developing nerve fibres know where to go and how do they reach
their target sites? ii) What determines the density and pattern of
inner vation at reaching the effector? iii) How do the nerves
survive and maintain their position once established? iv) What
factors influence neurochemical differentiation such that
genetically multipotential neu rones are triggered to synthesize
one or combinations of neurotransmit ters? v) What influence do
nerves have on the structure, function and receptor expression of
their effector cells? vi) How do diseases interrupt these
processes? - see 1]."
Many factors may influence the release of neurotransmitters from
airway nerves 1]. This is likely to be important in physiological
control of airway functions and may be particularly relevant in
airway diseases, such as asthma and chronic obstructive pulmonary
disease (COPD). Neural elements in airways interact in a complex
manner and the activation of certain neural pathways may profoundly
influence the release of transmitters from other neural pathways.
Similarly inflamma tory mediators released from inflammatory cells
in the airways may also modulate neurotransmitter release. There
are marked differences be tween species in airway innervation and
in neuromodulatory effects and, wherever possible, studies in human
airways have been emphasised, although information on
neuromodulation in human airways is some what limited at present.
Release of neurotransmitters from nerve terminals occurs via a Ca2+
dependent secretion evoked by a nerve action potential, but may
also be evoked experimentally by a high extracellular K +
concentration which directly depolarises the nerve terminal
membrane. Modulation refers to the alteration of neurotransmitter
release, which may either be increased (facilitation) or reduced
(inhibition) by the action of a particular agent, thus changing the
magnitude of the neurally-mediated response. Such agents would
normally act on receptors on the nerve terminal which are referred
to as pre-junctional (or presynaptic) receptors, in contrast to
post-junctional (or post-synaptic) receptors located on the target
cells which are influenced by that particular transmitter."
Continuing the Respiratory Pharmacology and Pharmacotherapy series,
this volume explores the pathophysiology and therapy of rhinitis.
The volume is introduced by a chapter describing the normal anatomy
and physiology of the nose and sinuses. Against this background the
contributing authors describe and discuss the immunological and
pathological changes which occur in rhinitis. The various causes
and the types of rhinitis - such as allergic, vasomotor, and
infectious - are discussed as are the treatments available
(pharmacotherapy, immunotherapy, surgery). The book concludes with
a description of the animal models of rhinitis which are now
available. This book will be of interest to bench scientists and
clinicians alike.
Building on the existing titles in the "Airways Smooth Muscle"
sub-series, the sixth volume explores physiological and
pharmacological processes in the lung in vivo. The various animal
models available for studying the bronchospasm and inflammation
associated with human asthma are thoroughly reviewed by
internationally recognised scientists. Specific chapters focus on
the problems of administering drugs to animal airways, the
mechanics of assessing lung function in the models, and describe in
detail the species used, from rodents to primates. The use of
genetically altered animals, an area of particular interest to
molecular biologists, is also considered in depth. This up-to-date
and extensively referenced work will prove invaluable to
pharmacologists, physiologists and other biological scientists at
all levels in academia and in the pharmaceutical industry.
Building on the existing titles in the "Airways Smooth Muscle"
sub-series, the sixth volume explores physiological and
pharmacological processes in the lung in vivo. The various animal
models available for studying the bronchospasm and inflammation
associated with human asthma are thoroughly reviewed by
internationally recognised scientists. Specific chapters focus on
the problems of administering drugs to animal airways, the
mechanics of assessing lung function in the models, and describe in
detail the species used, from rodents to primates. The use of
genetically altered animals, an area of particular interest to
molecular biologists, is also considered in depth. This up-to-date
and extensively referenced work will prove invaluable to
pharmacologists, physiologists and other biological scientists at
all levels in academia and in the pharmaceutical industry.
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Metamorphoses (Hardcover)
Ovid; Translated by David Raeburn
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Ovid's deliciously clever and exuberant epic, now in a gorgeous new
clothbound edition designed by the award-winning Coralie
Bickford-Smith. These delectable and collectable editions are bound
in high-quality, tactile cloth with foil stamped into the design.
Ovid's sensuous and witty poetry brings together a dazzling array
of mythological tales, ingeniously linked by the idea of
transformation - often as a result of love or lust - where men and
women find themselves magically changed into new and sometimes
extraordinary beings. Beginning with the creation of the world and
ending with the deification of Augustus, Ovid interweaves many of
the best-known myths and legends of Ancient Greece and Rome,
including Daedalus and Icarus, Pyramus and Thisbe, Pygmalion,
Perseus and Andromeda, and the fall of Troy. Erudite but
light-hearted, dramatic yet playful, theMetamorphoses has
influenced writers and artists throughout the centuries from
Shakespeare and Titian to Picasso and Ted Hughes. Ovid (43BC-18AD)
was born at Sulmo (Sulmona) in central Italy. Coming from a wealthy
Roman family and seemingly destined for a career in politics, he
held minor official posts before leaving public service to write,
becoming the most distinguished poet of his time. His works, all
published in Penguin Classics, include Amores, a collection of
short love poems; Heroides, verse-letters written by mythological
heroines to their lovers; Ars Amatoria, a satirical handbook on
love; and Metamorphoses, his epic work that has inspired countless
writers and artists through the ages. David Raeburn is a lecturer
in Classics at Oxford, and has also translated Sophocles' Electra
and Other Plays for Penguin Classics. Denis Feeney is Professor of
Classics at Princeton.
This scarce antiquarian book is a selection from Kessinger
Publishing's Legacy Reprint Series. Due to its age, it may contain
imperfections such as marks, notations, marginalia and flawed
pages. Because we believe this work is culturally important, we
have made it available as part of our commitment to protecting,
preserving, and promoting the world's literature. Kessinger
Publishing is the place to find hundreds of thousands of rare and
hard-to-find books with something of interest for everyone!
This scarce antiquarian book is a selection from Kessinger
PublishingAcentsa -a centss Legacy Reprint Series. Due to its age,
it may contain imperfections such as marks, notations, marginalia
and flawed pages. Because we believe this work is culturally
important, we have made it available as part of our commitment to
protecting, preserving, and promoting the world's literature.
Kessinger Publishing is the place to find hundreds of thousands of
rare and hard-to-find books with something of interest for e
Is women’s inequality supported by the Qur’an? Do men have the
exclusive right to interpret Islam’s holy scripture? In her
best-selling book Believing Women in Islam: Unreading Patriarchal
Interpretations of the Qur’an, Asma Barlas argues that, far from
supporting male privilege, the Qur’an actually encourages the
full equality of women and men. She explains why a handful of
verses have been interpreted to favor men and shows how these same
verses can be read in an egalitarian way that is fully supported by
the text itself and compatible with the Qur’an’s message that
it is complete and self-consistent. A Brief Introduction presents
the arguments of Believing Women in a simplified way that will be
accessible and inviting to general readers and undergraduate
students. The authors focus primarily on the Qur’an’s teachings
about women and patriarchy. They show how traditional teachings
about women’s inferiority are not supported by the Qur’an but
were products of patriarchal societies that used it to justify
their existing religious and social structures. The authors’ hope
is that by understanding how patriarchal traditionalists have come
to exercise so much authority in today’s Islam, as well as by
rereading some of the Qur’an’s most controversial verses,
adherents of the faith will learn to question patriarchal dogma and
see that an egalitarian reading of the Qur’an is equally possible
and, for myriad reasons, more plausible.
Building on the existing titles in the "Airways Smooth Muscle"
sub-series, the sixth volume explores physiological and
pharmacological processes in the lung in vivo. The various animal
models available for studying the bronchospasm and inflammation
associated with human asthma are thoroughly reviewed by
internationally recognised scientists. Specific chapters focus on
the problems of administering drugs to animal airways, the
mechanics of assessing lung function in the models, and describe in
detail the species used, from rodents to primates. The use of
genetically altered animals, an area of particular interest to
molecular biologists, is also considered in depth. This up-to-date
and extensively referenced work will prove invaluable to
pharmacologists, physiologists and other biological scientists at
all levels in academia and in the pharmaceutical industry.
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