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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology
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Airways Smooth Muscle: Development, and Regulation of Contractility - Development and Regulation of Contractility (Paperback, Softcover reprint of the original 1st ed. 1994)
Loot Price: R2,311
Discovery Miles 23 110
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Airways Smooth Muscle: Development, and Regulation of Contractility - Development and Regulation of Contractility (Paperback, Softcover reprint of the original 1st ed. 1994)
Series: Respiratory Pharmacology and Pharmacotherapy
Supplier out of stock. If you add this item to your wish list we will let you know when it becomes available.
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Most studies on autonomic innervation of smooth muscle have focused
on the short-term mechanisms involved in neurotransmission in
physiological and pathophysiological conditions. However recent
obser vations of the long-term plasticity of this system, i. e. its
capacity for regeneration and for compensatory change in pattern of
innervation and expression of cotransmitters and receptors in
ageing, following surgery, trauma or in disease, have indicated
that an understanding of the mechanisms involved could influence
the design of therapeutic regimes. There is increasing evidence for
long-term communication between nerves and smooth muscle cells
during development and throughout adult life. To date, the trophic
interactions between nerves and airway musculature have attracted
little interest, consequently, much of the information presented
here is drawn from studies using other smooth muscles. However, the
questions posed about trophic interactions dur ing development
apply as much to airways smooth muscle neuroeffector systems as to
other autonomic neuroeffector systems. These are: i) How do
developing nerve fibres know where to go and how do they reach
their target sites? ii) What determines the density and pattern of
inner vation at reaching the effector? iii) How do the nerves
survive and maintain their position once established? iv) What
factors influence neurochemical differentiation such that
genetically multipotential neu rones are triggered to synthesize
one or combinations of neurotransmit ters? v) What influence do
nerves have on the structure, function and receptor expression of
their effector cells? vi) How do diseases interrupt these
processes? - see 1]."
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