Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites? ii) What determines the density and pattern of inner vation at reaching the effector? iii) How do the nerves survive and maintain their position once established? iv) What factors influence neurochemical differentiation such that genetically multipotential neu rones are triggered to synthesize one or combinations of neurotransmit ters? v) What influence do nerves have on the structure, function and receptor expression of their effector cells? vi) How do diseases interrupt these processes? - see 1]."

Many factors may influence the release of neurotransmitters from airway nerves 1]. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Neural elements in airways interact in a complex manner and the activation of certain neural pathways may profoundly influence the release of transmitters from other neural pathways. Similarly inflamma tory mediators released from inflammatory cells in the airways may also modulate neurotransmitter release. There are marked differences be tween species in airway innervation and in neuromodulatory effects and, wherever possible, studies in human airways have been emphasised, although information on neuromodulation in human airways is some what limited at present. Release of neurotransmitters from nerve terminals occurs via a Ca2+ dependent secretion evoked by a nerve action potential, but may also be evoked experimentally by a high extracellular K + concentration which directly depolarises the nerve terminal membrane. Modulation refers to the alteration of neurotransmitter release, which may either be increased (facilitation) or reduced (inhibition) by the action of a particular agent, thus changing the magnitude of the neurally-mediated response. Such agents would normally act on receptors on the nerve terminal which are referred to as pre-junctional (or presynaptic) receptors, in contrast to post-junctional (or post-synaptic) receptors located on the target cells which are influenced by that particular transmitter."

Continuing the Respiratory Pharmacology and Pharmacotherapy series, this volume explores the pathophysiology and therapy of rhinitis. The volume is introduced by a chapter describing the normal anatomy and physiology of the nose and sinuses. Against this background the contributing authors describe and discuss the immunological and pathological changes which occur in rhinitis. The various causes and the types of rhinitis - such as allergic, vasomotor, and infectious - are discussed as are the treatments available (pharmacotherapy, immunotherapy, surgery). The book concludes with a description of the animal models of rhinitis which are now available. This book will be of interest to bench scientists and clinicians alike.

Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.

Continuing the Respiratory Pharmacology and Pharmacotherapy series, this volume explores the pathophysiology and therapy of rhinitis. The volume is introduced by a chapter describing the normal anatomy and physiology of the nose and sinuses. Against this background the contributing authors describe and discuss the immunological and pathological changes which occur in rhinitis. The various causes and the types of rhinitis - such as allergic, vasomotor, and infectious - are discussed as are the treatments available (pharmacotherapy, immunotherapy, surgery). The book concludes with a description of the animal models of rhinitis which are now available. This book will be of interest to bench scientists and clinicians alike.

Ovid's deliciously clever and exuberant epic, now in a gorgeous new clothbound edition designed by the award-winning Coralie Bickford-Smith. These delectable and collectable editions are bound in high-quality, tactile cloth with foil stamped into the design. Ovid's sensuous and witty poetry brings together a dazzling array of mythological tales, ingeniously linked by the idea of transformation - often as a result of love or lust - where men and women find themselves magically changed into new and sometimes extraordinary beings. Beginning with the creation of the world and ending with the deification of Augustus, Ovid interweaves many of the best-known myths and legends of Ancient Greece and Rome, including Daedalus and Icarus, Pyramus and Thisbe, Pygmalion, Perseus and Andromeda, and the fall of Troy. Erudite but light-hearted, dramatic yet playful, theMetamorphoses has influenced writers and artists throughout the centuries from Shakespeare and Titian to Picasso and Ted Hughes. Ovid (43BC-18AD) was born at Sulmo (Sulmona) in central Italy. Coming from a wealthy Roman family and seemingly destined for a career in politics, he held minor official posts before leaving public service to write, becoming the most distinguished poet of his time. His works, all published in Penguin Classics, include Amores, a collection of short love poems; Heroides, verse-letters written by mythological heroines to their lovers; Ars Amatoria, a satirical handbook on love; and Metamorphoses, his epic work that has inspired countless writers and artists through the ages. David Raeburn is a lecturer in Classics at Oxford, and has also translated Sophocles' Electra and Other Plays for Penguin Classics. Denis Feeney is Professor of Classics at Princeton.

Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.

Demonstrating Sophocles' aptitude for humanising figures from Greek myth and transforming simple fables into complex high tragedy, Electra and Other Plays is translated by David Raeburn with an introduction and notes by Pat Easterling. The plays collected in this volume show Sophocles' ability to create complex human characters struggling with profound moral issues. In Women of Trachis the agonizing death of the mighty Heracles is brought about by a tragic mistake made by his jealous wife Deianeira, as she attempts to regain his love. Set in the aftermath of the Trojan War, Ajax depicts a warrior driven into a homicidal rage that leads to his undoing, and Electra shows the grief-stricken children of the murdered Agamemnon and their plot to avenge him, while Philoctetes portrays the cunning Odysseus' attempt to convince a famed archer to rejoin the Greek expedition against Troy, undermined by the honesty of his young comrade Neoptolemus. David Raeburn's translation captures the rhythms of the original Greek, while remaining accessible to modern readers. Pat Easterling's general introduction discusses Athenian dramatic festivals, and the structure and tensions of the plays and their characters. This edition also includes a chronology, further reading, prefaces to each play and notes. Sophocles (496-405 BC) was born at Colonus, just outside Athens. His long life spanned the rise and decline of the Athenian Empire; he was a friend of Pericles, and though not an active politician he held several public offices, both military and civil. The leader of a literary circle and friend of Herodotus, Sophocles wrote over a hundred plays, drawing on a wide and varied range of themes, and winning the City Dionysia eighteen times; though only seven of his tragedies have survived, among them Antigone, Oedipus Rex, Ajax and Oedipus at Colonus. If you enjoyed Electra and Other Plays, you might like Sophocles' The Three Theban Plays, also available in Penguin Classics.

Is women’s inequality supported by the Qur’an? Do men have the exclusive right to interpret Islam’s holy scripture? In her best-selling book Believing Women in Islam: Unreading Patriarchal Interpretations of the Qur’an, Asma Barlas argues that, far from supporting male privilege, the Qur’an actually encourages the full equality of women and men. She explains why a handful of verses have been interpreted to favor men and shows how these same verses can be read in an egalitarian way that is fully supported by the text itself and compatible with the Qur’an’s message that it is complete and self-consistent. A Brief Introduction presents the arguments of Believing Women in a simplified way that will be accessible and inviting to general readers and undergraduate students. The authors focus primarily on the Qur’an’s teachings about women and patriarchy. They show how traditional teachings about women’s inferiority are not supported by the Qur’an but were products of patriarchal societies that used it to justify their existing religious and social structures. The authors’ hope is that by understanding how patriarchal traditionalists have come to exercise so much authority in today’s Islam, as well as by rereading some of the Qur’an’s most controversial verses, adherents of the faith will learn to question patriarchal dogma and see that an egalitarian reading of the Qur’an is equally possible and, for myriad reasons, more plausible.

This scarce antiquarian book is a selection from Kessinger Publishing's Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone!

This scarce antiquarian book is a selection from Kessinger PublishingAcentsa -a centss Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for e

This book gives an up-to-date analysis of the epidemiology of asthma i n children and adults, the role of steroids in asthma management and n ew and novel asthma therapies. Specific chapters deal with the epidem iology of asthma mortality and of childhood asthma, others discuss the advantages and drawbacks of the use of b2-adenoreceptor agonists, cor ticosteroids, theophylline and new generation phosphodiesterase inhibi tors in the treatment of asthma. A new non-invasive method to assess a irway inflammation is also presented as well as steroid-sparing therap ies in asthma. The book addresses clinicians and basic scientists wit h an interest in asthma epidemiology, steroids and future therapies. I t is also of interest to clinical and no-clinical teachers in academic disciplines relating to respiratory disease.

to Nitric Oxide Biology.- 1. Nitric Oxide Synthesis and Actions.- 2. Reactive Oxygen and Reactive Nitrogen Species in the Lung.- Role of Endogenous Nitric Oxide in the Lung.- 3. Non-Adrenergic Non-Cholinergic Neurotransmission in the Airways: Role of Nitric Oxide.- 4. Localisation of Nitric Oxide Synthases in the Lung.- 5. Role of Nitric Oxide in the Regulation of Pulmonary Vascular Tone.- 6. Nitric Oxide and Bronchial Hyperresponsiveness.- 7. Bronchodilator Actions of Nitric Oxide and Related Compounds.- 8. Role of Nitric Oxide in Airway Inflammation.- Therapeutic Potential of Inhalded Nitric Oxide and Nitric Oxide Synthase Inhibitors in Lung Disease.- 9. Nitric Oxide in Exhaled Air: Relevance in Inflammatory Lung Disease.- 10. Luminal Nitric Oxide in the Upper Airways: Implications for Local and Distal Sites of Action.- 11. Inhaled Nitric Oxide as a Therapy for Diseases of the Pulmonary Vasculature.- 12. Combinded Use of Nitric Oxide and Nitric Oxide Synthase Inhibitors as a Possible Therapeutic Approach.

1. Gene Therapy.- Asthma.- 2. Genetics of Asthma.- 3. Transcription Factors and Inflammatory Lung Disease.- 4. Regulation of the Cytokine Gene Cluster on Chromosome 5q.- 5. Cytokine Expression in Asthma.- 6. ?-Adrenoceptors.- 7. Regulation of Eosinophil Migration.- 8. Proteinase Allergens of House Dust Mites: Molecular Biology, Biochemistry and Possible Functional Significance of Their Enzyme Activity.- Cancer.- 9. Gene Expression in Lung Cancer.- 10. Gene Therapy for Cancer: Prospects for the Treatment of Lung Tumours.

1. Application of Transgenic and Gene-Targeted Mice to Dissect Mechanisms of Lung Disease.- Emphysema.- 2. Models of Genetic Emphysema: The C57B1/6J Mice and their Mutants: Tight-Skin, Pallid and Beige Giuseppe Lungarella, Eleonora Cavarra and.- 3. ?1-Antitrypsin Deficiency.- 4. Recombinant SLPI: Emphysema and Asthma.- 5. Elastase Inhibitors in the Lung: Expression and Functional Relationships.- 6. Regulation of Neutrophil Proteinases.- 7. Control of Connective Tissue Genes.- Infection.- 8. Genetic Models of Bacterial Lung Infection.- 9. Genetics of Bacteria: Role in Pathogenesis of Infection of the Respiratory Tract.- 10. Polymerase Chain Reaction in the Diagnosis of Respiratory Tract Infections.- 11. Cystic Fibrosis.- 12. Respiratory Bacterial Infections in Patients with Cystic Fibrosis: Pathogenicity and Implications for Serine Proteinase Inhibitor Therapy.

1. Prevention and Early Detection of Lung Cancer - Clinical Aspects.- 2. Smoking Prevention and Cessation.- 3. Clinical Pharmacology of Vitamin A and Retinoids.- 4. Early Lung Cancer Detection.- 5. Molecular Abnormalities in the Sequential Development of Lung Carcinoma.- 6. Application of In Situ PCR and In Situ Hybridization to the Characterization of Lung Cancers.- 7. Tumor Stroma Formation in Lung Cancer.- 8. Tumor Angiogenesis: Basis for New Prognostic Factors and New Anticancer Therapies.- 9. Cell Cycle Regulators and Mechanisms of Growth Control Evasion in Lung Cancer.- 10. Molecular Genetics of Lung Cancer.- 11. Neuropeptides, Signal Transduction and Small Cell Lung Cancer.- 12. In Vitro Analysis of Bombesin/Gastrin-Releasing Peptide Receptor (bb2) Ligand Binding and G-Protein Coupling.- 13. DNA Methylation Changes in Lung Cancer.- 14. K-ras Mutations as Molecular Markers of Lung Cancer.- 15. Sheep Lung Adenomatosis: A Model of Virally Induced Lung Cancer.- 16. Retinoic Acid Receptor ss An Exploration of its Role in Lung Cancer Suppression and its Potential in Cancer Prevention.- 17. Cytochrome P450 Polymorphisms: Risk Factors for Lung Cancer?.- 18. Glutathione S-Transferases and Lung Cancer Risk.- 19. The p53 Tumor Suppressor Gene in Lung Cancer: From Molecular to Serological Diagnosis.- 20. Endoscopic Localization of Preneoplastic Lung Lesions.- 21. Antigen Retrieval Improves hnRNP A2/B1 Immunohisto-chemical Localization in Premalignant Lesions of the Lung.- 22. Molecular Pathological Mechanisms in NSCLC and the Assessment of Individuals with a High Risk of Developing Lung Cancer.- 23. Chemoprevention of Lung Cancer.- 24. Regional Delivery of Retinoids: A New Approach to Early Lung Cancer Intervention.- 25. Natural Inhibitors of Carcinogenesis.- 26. Gene Delivery to Airways.- 27. Lung Cancer Prevention: The Point of View of a Public Health Epidemiologist.- 28. Biomarkers as Intermediate Endpoints in Chemoprevention Trials: Biological Basis of Lung Cancer Prevention.- 29. Biological Tools for Mass Screening.- 30. Optimization of the Use of Biological Samples for the Prospective Evaluation of Preneoplastic Lesions.

This commentary discusses Aeschylus' play Agamemnon (458 BC), which is one of the most popular of the surviving ancient Greek tragedies, and is the first to be published in English since 1958. It is designed particularly to help students who are tackling Aeschylus in the original Greek for the first time, and includes a reprint of D. L. Page's Oxford Classical Text of the play.
The introduction defines the place of Agamemnon within the Oresteia trilogy as a whole, and the historical context in which the plays were produced. It discusses Aeschylus' handling of the traditional myth and the main ideas which underpin his overall design: such as the development of justice and the nature of human responsibility; and it emphasizes how the power of words, seen as ominous speech-acts which can determine future events, makes a central contribution to the play's dramatic momentum. Separate sections explore Aeschylus' use of theatrical resources, the role of the chorus, and the solo characters. Finally there is an analysis of Aeschylus' distinctive poetic style and use of imagery, and an outline of the transmission of the play from 458 BC to the first printed editions.

This commentary discusses Aeschylus' play Agamemnon (458 BC), which is one of the most popular of the surviving ancient Greek tragedies, and is the first to be published in English since 1958. It is designed particularly to help students who are tackling Aeschylus in the original Greek for the first time, and includes a reprint of D. L. Page's Oxford Classical Text of the play.
The introduction defines the place of Agamemnon within the Oresteia trilogy as a whole, and the historical context in which the plays were produced. It discusses Aeschylus' handling of the traditional myth and the main ideas which underpin his overall design: such as the development of justice and the nature of human responsibility; and it emphasizes how the power of words, seen as ominous speech-acts which can determine future events, makes a central contribution to the play's dramatic momentum. Separate sections explore Aeschylus' use of theatrical resources, the role of the chorus, and the solo characters. Finally there is an analysis of Aeschylus' distinctive poetic style and use of imagery, and an outline of the transmission of the play from 458 BC to the first printed editions.

Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.