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This book focuses on histone mutations, especially those mutations
closely related to cancer. Genetic mutations and epigenetic
alterations contribute to the development of a variety of cancers:
recent genetic studies have identified e.g. H3K27M and H3G34R/V
mutation in over 75% of DIPG cases, H3.3K36M mutation in more than
90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of
giant cell tumors of bone. Given the high incidence and
tumorigenesis effects of histone H3 mutations, they are also
referred to as oncohistones. This book highlights the advances made
in the area over the past 10 years, and offers a state-of-the-art
summary of epigenetic alternation, gene expression, protein
structure, drug discovery, immunotherapy, and mouse modeling of
histone H3 mutations in various tumors. Chiefly intended to provide
researchers and graduate students with an overall picture of these
mutations, it will also be of interest to researchers in basic
oncology, clinical oncology, and epigenetics, as well as academics
and clinical oncology practitioners.
This book focuses on histone mutations, especially those mutations
closely related to cancer. Genetic mutations and epigenetic
alterations contribute to the development of a variety of cancers:
recent genetic studies have identified e.g. H3K27M and H3G34R/V
mutation in over 75% of DIPG cases, H3.3K36M mutation in more than
90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of
giant cell tumors of bone. Given the high incidence and
tumorigenesis effects of histone H3 mutations, they are also
referred to as oncohistones. This book highlights the advances made
in the area over the past 10 years, and offers a state-of-the-art
summary of epigenetic alternation, gene expression, protein
structure, drug discovery, immunotherapy, and mouse modeling of
histone H3 mutations in various tumors. Chiefly intended to provide
researchers and graduate students with an overall picture of these
mutations, it will also be of interest to researchers in basic
oncology, clinical oncology, and epigenetics, as well as academics
and clinical oncology practitioners.
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C++ Programming (Paperback)
Yuan Dong, Fang Yang; Edited by Li Zheng; Contributions by Tsinghua University Press
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R1,993
R1,857
Discovery Miles 18 570
Save R136 (7%)
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Out of stock
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This book begins by explaining key concepts in programming, and
elaborates on characteristic of class, including inheritance,
derivation and polymorphism. It also introduces generic programming
and Standard Template Library, I/O Stream Library and Exception
Handling. The concepts and methods are illustrated via examples
step by step, making the book an essential reading for beginners to
C++ programming.
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