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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Histone Mutations and Cancer (Paperback, 1st ed. 2021)
Loot Price: R2,953
Discovery Miles 29 530
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Histone Mutations and Cancer (Paperback, 1st ed. 2021)
Series: Advances in Experimental Medicine and Biology, 1283
Expected to ship within 10 - 15 working days
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This book focuses on histone mutations, especially those mutations
closely related to cancer. Genetic mutations and epigenetic
alterations contribute to the development of a variety of cancers:
recent genetic studies have identified e.g. H3K27M and H3G34R/V
mutation in over 75% of DIPG cases, H3.3K36M mutation in more than
90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of
giant cell tumors of bone. Given the high incidence and
tumorigenesis effects of histone H3 mutations, they are also
referred to as oncohistones. This book highlights the advances made
in the area over the past 10 years, and offers a state-of-the-art
summary of epigenetic alternation, gene expression, protein
structure, drug discovery, immunotherapy, and mouse modeling of
histone H3 mutations in various tumors. Chiefly intended to provide
researchers and graduate students with an overall picture of these
mutations, it will also be of interest to researchers in basic
oncology, clinical oncology, and epigenetics, as well as academics
and clinical oncology practitioners.
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