Oviductal Recognition of Embryonic Signals; H.B. Croxatto, et al. Effect of Progesterone Antagonists on Ovo-Endometrial Interactions; A. Psychoyos. On the Requirement for Estrogen for Establishing Pregnancy in the Non-Human Primate; N.R. Moudgal. Embryonic Loss and Conceptus Interferon Production; R.M. Roberts. In Vitro Models of Implantation; S.R. Glasser, et al. Uterine EGF Ligand-Receptor Circuitry and Its Role in EmbryoUterine Interactions during Implantation in the Mouse; S.K. Dey, et al. Human Uterine Angiogenic Factor (HUAF). The Role of Lymphohematopoietic Cytokines in Signalling between the Immune and Reproductive Systems; T.G. Wegmann. Human Decidual Function in Trophoblast and Uterine interaction; T. Mori, et al. Cytokines at the Maternal Fetal Interface: Colony Stimulating Factor1 as a Paradigm for the Maternal Regulation of Muridae Rodents; C. Tachi. Hormonal Regulation of Uterine Complement; K.B. Isaacson, et al. Insulinlike Growth Factor Binding Proteins: A Paradigm for Conceptus-Maternal Interactions in the Primate; A.T. Fazleabas, et al. The Roles of Growth Factors and Their Receptors in Peri-Implantation Mouse Embryos and at the Embryomaternal Interface; Z. Werb, et al. Ligands and Receptors of the Insulin Family: Role in Early Mammalian Development; S. Heyner, et al. 6 additional articles. Index.

Preterm delivery is a major public health concern. Recent developments, such as the preventive use of progesterone, and new data on possible mechanisms of initiation of parturition, have placed the topic at the forefront of the interests and preoccupation of many in maternal-fetal medicine and obstetrics. This balanced, authoritative, and well-referenced work offers a rigorous underpinning of basic science, highlighted translational science sections, and evidence-based clinical guidelines.

For over 40 years, Yen & Jaffe's Reproductive Endocrinology has been the gold standard text of both basic science and clinical practice of the full range of female and male reproductive disorders. The fully revised 9th Edition continues this tradition of excellence with complete coverage, including up-to-date information on impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, contraception, and more. An outstanding editorial board and other global experts in the field share their knowledge and expertise to keep you abreast of current science and practice in endocrinology. Includes new chapters on Meiosis, Fertilization and Embryo Development; Recurrent Pregnancy Loss; Uterus Transplantation; Mitochondrial Transplantation and Gene Editing; and Germs Cells Developed In Vitro. Provides extensively revised information on contemporary practices in assisted reproduction, fertility preservation, and ovulation induction. Provides an online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging. Adds three new members to the exceptional editorial team: Drs. Anuja Dokras, Carmen J. Williams, and Zev Williams. Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction. Includes bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section. Lists Top References at the end of each chapter that distill the most important references for research underpinnings, to complement the complete online reference list. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Human reproduction is the most dynamic of processes. The events which lead to the birth of a normal healthy infant have their origin long before actual fertilization. Indeed, the whole process can be looked upon as a continuum. Human fertilization and early development, once sequestered in the protective environment of the fallopian tubes and uterus, have now been exposed in the laboratory. These events have, over time, been extensively observed and catalogued in animal models. The tools of modem morphology and molecular biology have reopened issues long since considered settled as facets of early reproduction are reexplored. This volume, consisting of the proceedings of a workshop on uterine and embryonic factors in early pregnancy, has been designed to enhance that effort. Attention is focused largely on early embryonal development with special attention to the interrelationship between the embryo and the uterus in early pregnancy. Each of the contributing scientists brings with him or her the perspective of one specific discipline or another. The common denominator is the application of emerging techniques in modem molecular biology to problems pertaining to embryonal-uterine interaction. The goal is to consider specific areas of concern in a multidisciplinary way and to reexplore the factors behind early development and implantation. Uterine complement, the function of uterine macrophages immunoregulatory loops in the peri-implantation period, colony stimulating factors and interferon-like factors are reviewed and their interrelationship explored. Uterine angiogenesis factors as well as embryonic growth factors are also considered.

The regulation of cell death in various reproductive tissues, as in other ma jor organ systems of the body, has become a focal point of research activity in many laboratories over the past few years. As such, the need for a "for mal" meeting to highlight recent work in this field, as well as to integrate knowledge from other sources (such as investigators working on cell death in cancer and immune function) in the broad context of identifying con served pathways that coordinate life-and-death decisions in diverse cell types, became apparent. Therefore, the goals of the Scientific Committee of the International Symposium on Cell Death in Reproductive Physiology, spon sored by Serono Symposia USA, were already predetermined by this need. Simply stated, we sought to bring together for the first time a select cohort of reproductive biologists and cell death researchers, many but not all cho sen based on their pioneering efforts in elucidating the fundamental aspects of apoptosis in reproductive and nonreproductive tissues, as a means to re view the current status of the field, foster new ideas, and promote scientific collaborations. In the ensuing chapters of this book, summaries of work dis cussed at the meeting are presented to emphasize both the diversity and the similarities in the occurrence and regulation of apoptosis in tissues of the male and female reproductive systems.

Die pathologische Anatomie der Placenta beschlagt ein: Forschungsgebiet, das uber viele Jahre vernachlassigt worden ist. Sie gehorte zum Niemandsland zwi schen Geburtshelfer und Anatomen. Dies ganz zu Unrecht, bietet doch die normale und pathologische Anatomie der Placenta eine Fulle interessanter Probleme. Gegenuber den alteren Darstellungen der pathologischen Anatomie der Placenta sind in den letzten drei Jahrzehnten wesentliche neue Aspekte hinzugekommen: 1. hat das normalanatomische Bild der Placenta durch elektronenoptische Untersuchungen eine ungewohnliche Bereicherung erfahren; 2. ist die Placenta ein Spiegel der verschiedensten Membranfunktionen; 3. hat die anatomische Uberprufung der Placenta im Hinblick auf die peri natale Mortalitat eine wesentliche Aufwertung und Vertiefung erfahren; 4. nimmt die Placenta in der Abklarung der hypoxamischen Gewebsschadi gungen, insbesondere der Chromosomen des Foetus, eine Schlusselstellung ein. Die Einfuhrung in die normale Anatomie der Placenta, einschliesslich der elektronenoptischen Befunde, hat in dankenswerter Weise Herr Professor Dr. F. Strauss vom Anatomischen Institut in Bern ubernommen. Er hat sich seit Jahrzehnten mit diesem Problem beschaftigt. Die Bearbeitung der pathologischen Anatomie der Placenta liegt in den Handen von Professor Dr. K. Benirschke und Frau Dr. S. Driscoll. Professor Benirschke hat sich zunachst unter Leitung von Professor Dr. A. Hertig an der Harvard Medical School in Boston, Mass. (USA), dann in selbstandiger Stellung an der Dartmouth Medical School Hanover, New Hampshire, um die Abklarung der pathologischen Anatomie der Placenta be muht. Er verfugt, zusammen mit seiner Mitarbeiterin, Frau Dr."