This issue of Veterinary Clinics: Equine Practice, guest edited by Dr. Carrie Finno, focuses on Equine Genetic Diseases. Topics include: Genetics, Genomics, and Emergent Precision Medicine 12 years post Equine Reference Genome; Equine SNP Genotyping Arrays; Next-generation Sequencing; Genetic Testing in the Horse; Genetics of Cardiovascular Disease; Genetics of Respiratory Disease; Genetics of Neurological Disease; Genetics of Immune Disease; Genetics of Orthopedic Disease; Genetics of Ocular Disease; Genetics of Skin Disease; Genetics of Endocrine and Metabolic Disease; Genetics of Muscle Disease; Genetics of Laminitis; Genetics of Reproductive Diseases; and Genetics of Behavioral Traits.