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This exciting Handbook provides an authoritative and comprehensive
overview of managerial behavior and occupational health. Containing
both theoretical and empirical contributions written by eminent
academics, the Handbook covers a range of factors that influence
behavior including migration and health, job insecurity, the impact
of age diversity, work stress and health in the context of social
inequality as well as occupational health from a psychological
perspective. It is an essential reference tool to further research
on psychology, stress and understanding the behaviors of health
within working environments. The book will be invaluable to
academics and students in the fields of occupational health.
The prevalence of hypertension is almost three times as high as
that of diabetes mellitus type 2, with both conditions being major
risk factors for stroke, ischemic heart disease, cardiac
arrhythmias, and heart failure. The exact prevalence of
hypertension related to hormonal derangements (endocrine
hypertension) is not known but estimated to affect less than 15% of
hypertensive patients. Recent scientific discoveries have increased
the understanding of the pathophysiologic mechanisms of
hypertension. In Endocrine Hypertension, a renowned panel of
experts provides a comprehensive, state-of-the-art overview of this
disorder, discussing when to assign an endocrine cause in one of
many conditions that may present with hypertension. The first part
of Endocrine Hypertension is dedicated to adrenal causes. The
second part of the volume concerns potential nonadrenal causes of
hypertension, such as growth hormone excess or deficiency, primary
hyperparathyroidism, vitamin D deficiency, testosterone deficiency,
insulin resistance, obesity-associated hypertension, and the role
of central mineralocorticoid receptors and cardiovascular disease.
An important contribution to the literature, Endocrine Hypertension
is an indispensable reference not only for endocrinologists,
diabetologists, and adrenal investigators, but also for
translational scientists and clinicians from cardiology, internal
medicine, pediatrics, family medicine, geriatrics, urology, and
reproductive medicine / gynecology.
It has been over 50 years since Hans Selye formulated his concept
of stress. This came after the isolation of epinephrine and
norepinephrine and after the sympathetic system was associated with
Walter Cannon's "fight or flight" response. The intervening years
have witnessed a number of dis coveries that have furthered our
understanding of the mechanisms of the stress response. The
isolation, identification and manufacture of gluco corticoids, the
identification and synthesis of ACTH and vasopressin, and the
demonstration of hypothalamic regulation of ACTH secretion were
pivotal discoveries. The recent identification and synthesis of CRR
by Willie Vale and his colleagues gave new impetus to stress
research. Several new concepts of stress have developed as a result
of advances in bench research. These include the concept of an
integrated "stress sys tem," the realization that there are
bi-directional effects between stress and the immune system, the
suggestion that a number of common psychiatric disorders represent
dysregulation of systems responding to stress, and the
epidemiologic association of stress with the major scourges of
humanity."
The prevalence of hypertension is almost three times as high as
that of diabetes mellitus type 2, with both conditions being major
risk factors for stroke, ischemic heart disease, cardiac
arrhythmias, and heart failure. The exact prevalence of
hypertension related to hormonal derangements (endocrine
hypertension) is not known but estimated to affect less than 15% of
hypertensive patients. Recent scientific discoveries have increased
the understanding of the pathophysiologic mechanisms of
hypertension. In Endocrine Hypertension, a renowned panel of
experts provides a comprehensive, state-of-the-art overview of this
disorder, discussing when to assign an endocrine cause in one of
many conditions that may present with hypertension. The first part
of Endocrine Hypertension is dedicated to adrenal causes. The
second part of the volume concerns potential nonadrenal causes of
hypertension, such as growth hormone excess or deficiency, primary
hyperparathyroidism, vitamin D deficiency, testosterone deficiency,
insulin resistance, obesity-associated hypertension, and the role
of central mineralocorticoid receptors and cardiovascular disease.
An important contribution to the literature, Endocrine Hypertension
is an indispensable reference not only for endocrinologists,
diabetologists, and adrenal investigators, but also for
translational scientists and clinicians from cardiology, internal
medicine, pediatrics, family medicine, geriatrics, urology, and
reproductive medicine / gynecology.
This volume represents the first attempt to present in one place
the clinical syndromes and the pathophysiologic basis for the
"resistance states" to each of the classes of steroid hormones.
Glucocorticoids, mineralocorticoids, androgens, estrogens,
progesterone and vitamin D have widely diverse roles ranging from
the control of homeostasis to reproduction and bone formation. They
are similar in that they share a chemical structure and that their
action is in the cell nucleus where they induce transcription of
specific genes leading to synthesis of function-specific proteins.
Clinical syndromes of steroid hormone resistance to androgens
(complete and partial testicular feminization), aldosterone (pseudo
hypoaldosteronism) and vitamin D (vitamin D-dependent rickets type
II) have been known for many years. Progesterone and glucocorticoid
resistance syndromes have been described only recently. Resistance
to estrogens has not been reported in man or in animals. It is
hoped that a detailed reexamination of what is known about each of
these conditions at the clinical and molecular levels will enhance
our understanding of the function of these hormones and their
mechanisms of action. New insight and research initiatives should
result. G.P. Chrousos D.L. Loriaus M.B. Lipsett vii ACKNOWLEDGMENTS
The contents of this volume are based in part on the proceedings of
an International Conference held in Bethesda in the summer of 1984.
This conference was sponsored by the National Institute of Child
Health and Human Development, Bethesda, Maryland."
In Adrenal Disorders, a panel of distinguished physicians and
researchers select the most relevant new findings and integrate
them into the existing body of clinical knowledge on adrenal
pathologies. The book includes important reviews of disturbances in
cortisol homeostasis, and new concepts regarding adrenal tumors and
hereditary adrenal diseases. Also discussed are mineralocorticoids
and the syndromes of mineralocortoid excess and aldosterone
synthase deficiency. Authoritative and insightful, Adrenal
Disorders provides physicians and scientists with a comprehensive,
state-of-the-art practical guide to the devastating diseases of the
adrenals that are so often difficult to diagnose and treat.
In Adrenal Disorders, a panel of distinguished physicians and
researchers select the most relevant new findings and integrate
them into the existing body of clinical knowledge on adrenal
pathologies. The book includes important reviews of disturbances in
cortisol homeostasis, and new concepts regarding adrenal tumors and
hereditary adrenal diseases. Also discussed are mineralocorticoids
and the syndromes of mineralocortoid excess and aldosterone
synthase deficiency. Authoritative and insightful, Adrenal
Disorders provides physicians and scientists with a comprehensive,
state-of-the-art practical guide to the devastating diseases of the
adrenals that are so often difficult to diagnose and treat.
It has been over 50 years since Hans Selye formulated his concept
of stress. This came after the isolation of epinephrine and
norepinephrine and after the sympathetic system was associated with
Walter Cannon's "fight or flight" response. The intervening years
have witnessed a number of dis coveries that have furthered our
understanding of the mechanisms of the stress response. The
isolation, identification and manufacture of gluco corticoids, the
identification and synthesis of ACTH and vasopressin, and the
demonstration of hypothalamic regulation of ACTH secretion were
pivotal discoveries. The recent identification and synthesis of CRR
by Willie Vale and his colleagues gave new impetus to stress
research. Several new concepts of stress have developed as a result
of advances in bench research. These include the concept of an
integrated "stress sys tem," the realization that there are
bi-directional effects between stress and the immune system, the
suggestion that a number of common psychiatric disorders represent
dysregulation of systems responding to stress, and the
epidemiologic association of stress with the major scourges of
humanity."
This open access book sets out the stress-system model for
functional somatic symptoms in children and adolescents. The book
begins by exploring the initial encounter between the
paediatrician, child, and family, moves through the assessment
process, including the formulation and the treatment contract, and
then describes the various forms of treatment that are designed to
settle the child's dysregulated stress system. This approach both
provides a new understanding of how such symptoms emerge -
typically, through a history of recurrent or chronic stress, either
physical or psychological - and points the way to effective
assessment, management, and treatment that put the child (and
family) back on the road to health and well-being.
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