Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon. In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association. We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design.

This book presents an in-depth study of organizational change and innovation in one of the UK's leading retail leisure companies. Based on a remarkably deep level of access, the authors provide a fascinating longitudinal study of the management process in action - both the formal, 'on stage' aspects of strategic change and the informal, political behaviour of those involved.
Subjects covered include:
* the changing contexts of the public house business
* from management to managing
* change processes and politics
* control and empowerment
* gender and public house management.
Work, Change and Competition will be essential reading for students of organizational change, as well as all readers interested in the changing nature of management/managing and organizations.

This book presents an in-depth study of organizational change and innovation in one of the UK's leading retail leisure companies. Based on a remarkably deep level of access, the authors provide a fascinating longitudinal study of the management process in action - both the formal, 'on stage' aspects of strategic change and the informal, political behaviour of those involved. Subjects covered include: * the changing contexts of the public house business * from management to managing * change processes and politics * control and empowerment * gender and public house management. Work, Change and Competition will be essential reading for students of organizational change, as well as all readers interested in the changing nature of management/managing and organizations.

Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon. In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association. We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design.

On Christmas Eve, New York cop John McClane (Bruce Willis) is visiting his estranged wife Holly (Bonnie Bedelia) in Los Angeles, where she works. They are attending a party at Holly's high-rise office block when terrorists, led by the suave Hans Gruber (Alan Rickman) break in, taking everyone hostage. McClane manages to evade capture, however, and sets out to rescue his wife and the other prisoners. It is not long before he is running barefoot over shattered glass (ouch!) in a sweaty vest, muttering 'Yippy kay aye' as he dispatches the baddies with bullets and a certain earthy wit.

For 30 years, the OPCI has provided Doctors and Patients with time saving, truly comprehensive communication success in the exam room. Features: - 32 Full Color, new larger size 8-1/2"x11" Illustrations Portfolio - All subjects, Cataract, Cornea, Retina, Glaucoma, Refractive Surgery - New, higher quality images added - Eliminates your struggle to have patients understand his/her problem - Patients appreciate your clarity -Simple in-the-drawer access - no expensive computer needed

The classic dental exam room illustrated portfolio from Dental Artist Stephen F. Gordon. Now updated with 6 new topics. Eliminates your struggle to have patients understand his/her problem. Saves valuable time. Patients appreciated your clarity. Includes 1. Proper Brushing/Flossing 2. Primary Teeth 3. Permanent Teeth 4. Normal Teeth 5. Tooth Decay / Repair 6. Gumline Decay 7. Pockets & Root Decay 8. Periodontal Disease A 9. Periodontal Disease B 10. Root Canal 11. Inlays/Onlays 12. Pins/Posts/Cores 13. Crown 14. Bridge 15. Implants 16. Removable Partial Denture 17. Maryland Bridge 18. Bonding/Veneer 19. Sealants 20. Impaction 21. TMJ 22. New Denture 23. Malocclusion 24. Tooth Formation 25. Primaries - Why Repair 26,27,28. Why Crown -forces, problems, solution

For 30 years, the PPCI has provided Doctors and Patients with time saving, truly comprehensive communication success in the exam room. Features: - 32 Full Color, new larger size 8-1/2"x11" Illustrations Portfolio - All subjects, Cataract, Cornea, Retina, Glaucoma, Refractive Surgery - New, higher quality images added - Eliminates your struggle to have patients understand his/her problem - Patients appreciate your clarity -Simple in-the-drawer access - no expensive computer needed

The Deluxe Edition of the classic DPCI dental exam room illustrated portfolio from Dental Artist Stephen F. Gordon is now updated with 6 new topics. Eliminates your struggle to have patients understand his/her problem. Saves valuable time. Patients appreciated your clarity. Includes 1. Proper Brushing/Flossing 2. Primary Teeth 3. Permanent Teeth 4. Normal Teeth 5. Tooth Decay / Repair 6. Gumline Decay 7. Pockets & Root Decay 8. Periodontal Disease A 9. Periodontal Disease B 10. Root Canal 11. Inlays/Onlays 12. Pins/Posts/Cores 13. Crown 14. Bridge 15. Implants 16. Removable Partial Denture 17. Maryland Bridge 18. Bonding/Veneer 19. Sealants 20. Impaction 21. TMJ 22. New Denture 23. Malocclusion 24. Tooth Formation 25. Primaries - Why Repair 26,27,28. Why Crown -forces, problems, solution