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Big Data Analytics - 6th International Conference, BDA 2018, Warangal, India, December 18-21, 2018, Proceedings (Paperback, 1st ed. 2018)
Anirban Mondal, Himanshu Gupta, Jaideep Srivastava, P. Krishna Reddy, D.V.L.N. Somayajulu
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This book constitutes the refereed proceedings of the 6th
International Conference on Big Data analytics, BDA 2018, held in
Warangal, India, in December 2018. The 29 papers presented in this
volume were carefully reviewed and selected from 93 submissions.
The papers are organized in topical sections named: big data
analytics: vision and perspectives; financial data analytics and
data streams; web and social media data; big data systems and
frameworks; predictive analytics in healthcare and agricultural
domains; and machine learning and pattern mining.
Cancer is a disease characterized by reduction or loss of
effectiveness in normal cellular control mechanism which regulates
multiplication. A normal cell turns into a cancer cell because of
one or more mutations in its DNA, which can be acquired or
inherited. In the body, every cell type has its own unmatched
signature, referred to as biomarkers, they are useful in the
diagnosis, monitoring and in predicting the disease progression. It
is found that the mediators of inflammation are important
constituents of the local environment of tumors. In some types of
cancer, inflammatory conditions are present before a malignant
change develops. Conversely, in other types of cancer, an oncogenic
change induces an inflammatory microenvironment which promotes the
tumor development. In some cases, use of NSAIDs is associated with
lower risks for esophageal, gastric and colon cancers as well as
other solid tumors. Chronic intake of NSAIDs may reduce
carcinogenesis by inhibiting production of PGs, cytokines and
angiogenic factors. Moreover, the ability of these NSAIDs drugs to
prevent cancer is thought to be due, in part, to COX inhibition.
Poor ocular bioavailability of drugs (> 1%) from conventional
eye drops (i.e. solution, suspension and ointments) is mainly due
to the precorneal loss factor. Ocular efficacy is closely related
to ocular drug bioavailability, which may be enhanced by increasing
corneal drug penetration and prolonging precorneal drug residence
time. Sparfloxacin and levofloxacin are newer generation
hydrophobic fluoroquinolones. Poorly water soluble drugs are
difficult to develop as conventional ocular drug delivery system.
Nanotechnology can be used to formulate poorly water soluble drugs
as nanosuspension which can be further incorporated in to matrix of
hydrogel. This combination thus offers the opportunity to address
many of the formulation related issues with such drugs. A variety
of ocular drug delivery systems, such as hydrogels, microparticles,
nanoparticles, microemulsion, liposomes and collagen shields have
been designed and investigated for improved ocular bioavailability.
Amongst them, hydrogels and polymeric nanoparticles are the most
interesting approaches to achieve local sustained delivery system.
In the present work various hydrogel based systems are developed
and evaluated.
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