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Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.
Giving a fresh, substantial and in-depth overview of the topic,
this book brings together the latest results in the field of
metabolomics. It comprehensively presents the current state of the
metabolomics field by underscoring experimental methods, analysis
techniques, standardization practices, and advances in specific
model systems. As a result, it helps to significantly broaden our
perspective on the principles and strategies underpinning this
emerging field.
The present text is a complete revision of the 2nd edition from
2003 of the book with the same title. In recognition of the fast
pace at which biotechnology is moving we have rewritten several
chapters to include new scientific progress in the field from 2000
to 2010. More important we have changed the focus of the book to
support its use, not only in universities, but also as a guide to
design new processes and equipment in the bio-industry. A new
chapter has been included on the prospects of the bio-refinery to
replace many of the oil- and gas based processes for production of
especially bulk chemicals. This chapter also serves to make
students in Chemical Engineering and in the Bio-Sciences
enthusiastic about the whole research field. As in previous
editions we hope that the book can be used as textbook for classes,
even at the undergraduate level, where chemical engineering
students come to work side by side with students from biochemistry
and microbiology. To help the chemical engineering students Chapter
1 includes a brief review of the most important parts of microbial
metabolism. In our opinion this review is sufficient to understand
microbial physiology at a sufficiently high level to profit from
the rest of the book. Likewise the bio-students will not be
overwhelmed by mathematics, but since the objective of the book is
to teach quantitative process analysis and process design at a
hands-on level some mathematics and model analysis is needed. We
hope that the about 100 detailed examples and text notes, together
with many instructive problems will be sufficient to illustrate how
model analysis is used, also in Bio-reaction Engineering.
Metabolic engineering is a new field with applications in the
production of chemicals, fuels, materials, pharmaceuticals, and
medicine at the genetic level. The field's novelty is in the
synthesis of molecular biology techniques and the tools of
mathematical analysis, which allow rational selection of targets
for genetic modification through measurements and control of
metabolic fluxes. The objective is to identify specific genetics or
environmental manipulations that result in improvements in yield
and productivities of biotechnological processes.
Key features of the book are pathway integration and the focus on
metabolic flux as a fundamental determinant of cell physiology. The
book keeps mathematical complexity to a minimum, and provides a
glossary of biological terms to facilitate use of the book by a
broader spectrum of readers. A web page exists to communicate
updates of the codes and homework problems.
Key Features
* Demonstrates metabolic engineering in action with numerous
examples of pathway modification
* Includes methods for identifying key enzymes in metabolic
networks
* Contains a comprehensive review of metabolic biochemistry
* Discusses metabolic regulation at the gene, enzyme, operon, and
cell levels
* Explains concepts of stoichiometry, kinetics, and thermodynamics
of metabolic pathways
* Minimizes mathematical complexity
* Links to a Web page to communicate updates of the software code
and homework problems
Integrating recent research on the physiology and modelling of
bioreactions and bioreactors, the authors present a comprehensive,
unified introduction to the principles and practices of the field.
The work features nearly 100 detailed design examples and problems,
many of which are suitable for hands-on demonstrations on a
personal computer or for expanded research. The text will serve as
a highly instructive guide for students in bioengineering and
biotechnology, as well as biochemical, chemical, and environmental
engineering.
Metabolic engineering is a rapidly evolving field that is being
applied for the optimization of many different industrial
processes. In this issue of "Advances in " "Biochemical
Engineering/Biotechnology," developments in different areas of
metabolic engineering are reviewed. The contributions discuss the
application of metabolic engineering in the improvement of yield
and productivity - illustrated by amino acid production and the
production of novel compounds - in the production of polyketides
and extension of the substrate range - and in the engineering of
"S. cerevisiae" for xylose metabolism, and the improvement of a
complex biotransformation process.
Fermentation Microbiology and Biotechnology, 4th Edition explores
and illustrates the broad array of metabolic pathways employed for
the production of primary and secondary metabolites, as well as
biopharmaceuticals. This updated and expanded edition addresses the
whole spectrum of fermentation biotechnology, from fermentation
kinetics and dynamics to protein and co-factor engineering. It also
sheds light on the new strategies employed by industrialist for
increasing tolerance and endurance of microorganisms to the
accumulation of toxic wastes in microbial-cell factories. The new
edition builds upon the fine pedigree of its earlier predecessors
and extends the spectrum of the book to reflect the
multidisciplinary and buoyant nature of this subject area. Key
Features Covers the whole spectrum of the field from fermentation
kinetics to control of fermentation and protein engineering.
Includes case studies specifically designed to illustrate
industrial applications and current state-of-the-art technologies.
Presents the contributions of eminent international academics and
industrial experts. Offers new chapters addressing: The prospects
and the role of bio-fuels refineries, Control of metabolic efflux
to product formation in microbial-cell factories and Improving
tolerance of microorganisms to toxic byproduct accumulation in the
fermentation vessel.
The present text is a complete revision of the 2nd edition from
2003 of the book with the same title. In recognition of the fast
pace at which biotechnology is moving we have rewritten several
chapters to include new scientific progress in the field from 2000
to 2010. More important we have changed the focus of the book to
support its use, not only in universities, but also as a guide to
design new processes and equipment in the bio-industry. A new
chapter has been included on the prospects of the bio-refinery to
replace many of the oil- and gas based processes for production of
especially bulk chemicals. This chapter also serves to make
students in Chemical Engineering and in the Bio-Sciences
enthusiastic about the whole research field. As in previous
editions we hope that the book can be used as textbook for classes,
even at the undergraduate level, where chemical engineering
students come to work side by side with students from biochemistry
and microbiology. To help the chemical engineering students Chapter
1 includes a brief review of the most important parts of microbial
metabolism. In our opinion this review is sufficient to understand
microbial physiology at a sufficiently high level to profit from
the rest of the book. Likewise the bio-students will not be
overwhelmed by mathematics, but since the objective of the book is
to teach quantitative process analysis and process design at a
hands-on level some mathematics and model analysis is needed. We
hope that the about 100 detailed examples and text notes, together
with many instructive problems will be sufficient to illustrate how
model analysis is used, also in Bio-reaction Engineering.
Public diplomacy and nation branding have recently been important
topics in the diplomatic communities around the world and the
importance for governments of reaching out to foreign publics has
been recognized like never before. This book explores why these
concepts have risen to prominence amongst several ministries of
foreign affairs, particularly in Europe and North America, lately
and have become an integrated part of their diplomatic strategy.
Whether public diplomacy and nation branding will contribute to an
increased efficiency in reaching foreign policy goals is still
unclear and is investigated in detail. From a foundation of a
history of diplomatic practice the author explores if this new
trend signifies a new era of diplomacy and international relations,
or if it is merely an added function in a modern ministry of
foreign affairs with little impact on the way diplomacy and
communication between states have been conducted. This book will
help provide a better understanding of the latest trends in
diplomacy for the practitioner, student of international relations
or any person with a general interest in diplomacy and political
communication.
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