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A Community of Practice Approach to Improving Gender Equality in Research (Hardcover): Rachel Palmen, Joerg Muller A Community of Practice Approach to Improving Gender Equality in Research (Hardcover)
Rachel Palmen, Joerg Muller
R4,145 Discovery Miles 41 450 Ships in 12 - 17 working days

Bringing together the latest research among various communities of practice (disciplinary and place based as well as thematically organised), this volume reflects upon the knowledge, experience and practice gained through taking a unique community of practice approach to fostering gender equality in the sectors of research and innovation, and higher education in Europe and beyond. Based on research funded by the European Union, it considers how inter-organisational collaboration can foster change for gender equality through sharing of experiences of Gender Equality Plan implementation and examining the role of measures such as change-monitoring systems. As such, it will appeal to social scientists with interests in organisational change, the sociology of work and gender equality.

Agent-Oriented Software Engineering XIII - 13th International Workshop, AOSE 2012, Valencia, Spain, June 4, 2012, Revised... Agent-Oriented Software Engineering XIII - 13th International Workshop, AOSE 2012, Valencia, Spain, June 4, 2012, Revised Selected Papers (Paperback, 2013 ed.)
Joerg Muller, Massimo Cossentino
R1,429 Discovery Miles 14 290 Ships in 10 - 15 working days

This book constitutes the thoroughly refereed post-proceedings of the 13th Agent-Oriented Software Engineering (AOSE) workshop, held at the 11th International Conference on Autonomous Agents and Multiagent Systems, AAMAS 2012, in Valencia, Spain, in June 2012. This volume presents 9 thoroughly revised papers selected from 24 submissions as well as two invited articles by leading researchers in the field. The papers cover a broad range of topics related to software engineering of agent-based systems, with particular attention to the integration of concepts and techniques from multi-agent systems with recent programming languages, platforms, and established software engineering methodologies.

Multiagent based Supply Chain Management (Paperback, 2006): Brahim Chaib-Draa, Joerg Muller Multiagent based Supply Chain Management (Paperback, 2006)
Brahim Chaib-Draa, Joerg Muller
R4,539 Discovery Miles 45 390 Ships in 10 - 15 working days

This book takes a close look at recent progress in the field of supply chain management using agent technology and more specifically multiagent systems. Sixteen chapters are organized in four main parts: Introductory Papers; Multiagent Based Supply Chain Modeling; Collaboration and Coordination Between Agents in a Supply Chain; and Multiagent Based Supply Chain Management: Applications. The result is a comprehensive review of existing literature, and ideas for future research.

Agent-Based Technologies and Applications for Enterprise Interoperability - International Workshops ATOP 2009, Budapest,... Agent-Based Technologies and Applications for Enterprise Interoperability - International Workshops ATOP 2009, Budapest, Hungary, May 12, 2009, and ATOP 2010, Toronto, ON, Canada, May 10, 2010, Revised Selected Papers (Paperback, 2012 ed.)
Klaus Fischer, Joerg Muller, Renato Levy
R1,939 Discovery Miles 19 390 Ships in 10 - 15 working days

The ATOP (Agent-Based Technologies and Applications for Enterprise Interoperability) workshop series focuses on technologies that support interoperability in networked organizations, on successful applications of these technologies, and on lessons learned. In particular, ATOP brings together research combining ideas from MDA and SOA with agent technologies. The ATOP 2009 and 2010 workshops were held at the AAMAS conferences in Budapest, Hungary, in May 2009, and in Toronto, Canada, in May 2010. The 11 papers presented here were carefully reviewed by three members of the international Program Committee and selected out of 25 contributions to the workshops. The topics covered are modeling interoperable systems; semantic approaches to enterprise interoperability; and interoperable business processes and business interactions. These papers are completed by an invited contribution reporting on OMG agent standardization. The main goal was to collect approaches for the application of agent technologies in these areas. Current trends in the development of agent technologies are compared with recent developments in service-oriented and model-driven system design, with respect to their ability to solve interoperability problems.

Pervasive Advertising (Hardcover, 2011): Joerg Muller, Florian Alt, Daniel Michelis Pervasive Advertising (Hardcover, 2011)
Joerg Muller, Florian Alt, Daniel Michelis
R3,015 Discovery Miles 30 150 Ships in 10 - 15 working days

This book looks at the future of advertising from the perspective of pervasive computing. Pervasive computing encompasses the integration of computers into everyday devices, like the covering of surfaces with interactive displays and networked mobile phones. Advertising is the communication of sponsored messages to inform, convince, and persuade to buy. We believe that our future cities will be digital, giving us instant access to any information we need everywhere, like at bus stops, on the sidewalk, inside the subway and in shopping malls. We will be able to play with and change the appearance of our cities effortlessly, like making flowers grow along a building wall or changing the colour of the street we are in. Like the internet as we know it, this digitalization will be paid for by adverts, which unobtrusively provide us suggestions for nearby restaurants or cafes. If any content annoys us, we will be able to effortlessly say so and change it with simple gestures, and content providers and advertisers will know what we like and be able to act accordingly. This book presents the technological foundations to make this vision a reality.

Enterprise Interoperability - New Challenges and Approaches (Paperback, Softcover reprint of hardcover 1st ed. 2007): Guy... Enterprise Interoperability - New Challenges and Approaches (Paperback, Softcover reprint of hardcover 1st ed. 2007)
Guy Doumeingts, Joerg Muller, Gerard Morel, Bruno Vallespir
R5,830 Discovery Miles 58 300 Ships in 10 - 15 working days

Composed of over 50 papers, "Enterprise Interoperability" ranges from academic research through case studies to industrial and administrative experience of interoperability. The international nature of the authorship continues to broaden. Many of the papers have examples and illustrations calculated to deepen understanding and generate new ideas. This is a concise reference to the state-of-the-art in software interoperability.

Agent-Based Technologies and Applications for Enterprise Interoperability - International Workshops, ATOP 2005, Utrecht, The... Agent-Based Technologies and Applications for Enterprise Interoperability - International Workshops, ATOP 2005, Utrecht, The Netherlands, July 25-26, 2005, and ATOP 2008, Estoril, Portugal, May 12-13, 2008, Revised Selected Papers (Paperback, 2009 ed.)
Klaus Fischer, Joerg Muller, James J. Odell
R1,557 Discovery Miles 15 570 Ships in 10 - 15 working days

The ATOP (Agent-Based Technologies and Applications for Enterprise Interoperability) workshop series focuses on technologies that support interoperability in networked organizations, on successful applications of these technologies, and on lessons learned. So far two ATOP workshops have been held at the AAMAS conferences in Utrecht, The Netherlands, in July 2005, and in Estoril, Portugal, in May 2008. The 13 papers presented here are extended versions of carefully reviewed and selected contributions to the workshops. The topics covered are business interoperability; organizations and virtual institutions; modeling multiagent systems; agent interaction; and security. The main goal was to collect approaches for the application of agent technologies in these areas. Current trends in the development of agent technologies are compared with recent developments in service-oriented and model-driven system design, with respect to their ability to solve interoperability problems.

Multiagent System Technologies - 5th German Conference, MATES 2007, Leipzig, Germany, September 24-26, 2007, Proceedings... Multiagent System Technologies - 5th German Conference, MATES 2007, Leipzig, Germany, September 24-26, 2007, Proceedings (Paperback, 4. Aufl.)
Paolo Petta, Joerg Muller, Matthias Klusch, Michael Georgeff
R1,557 Discovery Miles 15 570 Ships in 10 - 15 working days

This book constitutes the refereed proceedings of the 5th German Conference on Multiagent Systems Technologies, MATES 2007, held in Leipzig, Germany, in September 2007, co-located with NetObjectDays (NODe 2007).

The 17 revised full papers presented were carefully reviewed and selected from 27 submissions. The papers are organized in topical sections on engineering multi-agent systems, multi-agent planning and learning, multi-agent communication, interaction, and coordination, multi-agent resource allocation, multi-agent planning and simulation, as well as trust and reputation.

Enterprise Interoperability II - New Challenges and Approaches (Hardcover, 2007 ed.): Ricardo Jardim-Goncalves, Joerg Muller,... Enterprise Interoperability II - New Challenges and Approaches (Hardcover, 2007 ed.)
Ricardo Jardim-Goncalves, Joerg Muller, Kai Mertins, Martin Zelm
R8,787 Discovery Miles 87 870 Ships in 10 - 15 working days

This volume provides a concise reference to the state-of-the-art in software interoperability. Composed of over 90 papers, Enterprise Interoperability II ranges from academic research through case studies to industrial and administrative experience of interoperability. The international nature of the authorship continues to broaden. Many of the papers have examples and illustrations calculated to deepen understanding and generate new ideas.

Agent-Oriented Software Engineering VI - 6th International Workshop, AOSE 2005, Utrecht, The Netherlands, July 25, 2005.... Agent-Oriented Software Engineering VI - 6th International Workshop, AOSE 2005, Utrecht, The Netherlands, July 25, 2005. Revised and Invited Papers (Paperback, 2006 ed.)
Joerg Muller, Franco Zambonelli
R1,641 Discovery Miles 16 410 Ships in 10 - 15 working days

Agent and multiagent concepts offer higher level abstractions and mechanisms which address issues such as knowledge representation and reasoning, communication, coordination, cooperation among heterogeneous and autonomous parties, perception, commitments, goals, beliefs, and intentions all of which need conceptual modeling. The AOSE 2005 workshop sought to examine the credentials of agent-based approaches as a software engineering paradigm, and to gain an insight into what agent-oriented software engineering will look like, and what its benefits will be.

This book represents the thoroughly refereed post-proceedings of the 6th International Workshop on Agent-Oriented Software Engineering, AOSE 2005, held in Utrecht, The Netherlands, in July 2005 as part of AAMAS 2005. The 18 revised full papers were carefully selected from 35 submissions during two rounds of reviewing and improvement. The papers are organized in topical sections on modeling tools, analysis and validation tools, multiagent systems design, implementation tools, and experiences and comparative evaluations.

Agent-Oriented Software Engineering IV - 4th International Workshop, AOSE 2003, Melbourne, Australia, July 15, 2003, Revised... Agent-Oriented Software Engineering IV - 4th International Workshop, AOSE 2003, Melbourne, Australia, July 15, 2003, Revised Papers (Paperback, 2004 ed.)
Paolo Giorgini, Joerg Muller, James Odell
R1,637 Discovery Miles 16 370 Ships in 10 - 15 working days

The explosive growth of application areas such as electronic commerce, ent- prise resource planning and mobile computing has profoundly and irreversibly changed our views on software systems. Nowadays, software is to be based on open architectures that continuously change and evolve to accommodate new components and meet new requirements. Software must also operate on di- rent platforms, without recompilation, and with minimal assumptions about its operating environment and its users. Furthermore, software must be robust and autonomous, capable of serving a naive user with a minimum of overhead and interference. Agent concepts hold great promise for responding to the new realities of so- ware systems. They o?er higher-level abstractions and mechanisms that address issues such as knowledge representation and reasoning, communication, coor- nation, cooperation among heterogeneous and autonomous parties, perception, commitments, goals, beliefs, and intentions, all of which need conceptual mo- ling. On the one hand, the concrete implementation of these concepts can lead to advanced functionalities, e.g., in inference-based query answering, transaction control, adaptive work?ows, brokering and integration of disparate information sources, and automated communication processes. On the other hand, their rich representational capabilities allow more faithful and ?exible treatments of c- plex organizational processes, leading to more e?ective requirements analysis and architectural/detailed design.

Multi-Agent Systems and Applications III - 3rd International Central and Eastern European Conference on Multi-Agent Systems,... Multi-Agent Systems and Applications III - 3rd International Central and Eastern European Conference on Multi-Agent Systems, CEEMAS 2003, Prague, Czech Republic, June 2003, Proceedings (Paperback, 2003 ed.)
Vladimir Marik, Joerg Muller, Michal Pechoucek
R3,300 Discovery Miles 33 000 Ships in 10 - 15 working days

The refereed proceedings of the International Central and Eastern European Conference on Multi-Agent Systems, CEEMAS 2003, held in Prague, Czech Republic, in June 2003. The 58 revised full papers presented together with 3 invited contributions were carefully reviewed and selected from 109 submissions. The papers are organized in topical sections on formal methods, social knowledge and meta-reasoning, negotiation, and policies, ontologies and languages, planning, coalitions, evolution and emergent behaviour, platforms, protocols, security, real-time and synchronization, industrial applications, e-business and virtual enterprises, and Web and mobile agents.

Agent Technologies, Infrastructures, Tools, and Applications for E-Services - NODe 2002 Agent-Related Workshop, Erfurt,... Agent Technologies, Infrastructures, Tools, and Applications for E-Services - NODe 2002 Agent-Related Workshop, Erfurt, Germany, October 7-10, 2002, Revised Papers (Paperback, 2003 ed.)
Ryszard Kowalczyk, Joerg Muller, Huaglory Tianfield, Rainer Unland
R1,587 Discovery Miles 15 870 Ships in 10 - 15 working days

  This book constitutes the thoroughly refereed post-proceedings of the three agent-related workshops held during the NetObjectDays international conference, NODe 2002, held in Erfurt, Germany, in October 2002. The 23 revised full papers presented with a keynote paper and 2 abstracts were carefully selected during 2 rounds of reviewing and improvement. The papers are organized in topical sections on agent-oriented requirements engineering and specification, agent-oriented software engineering, reuse, negotiation and communication, large complex systems, e-business, and applications.

Intelligent Agents V: Agents Theories, Architectures, and Languages - 5th International Workshop, ATAL'98, Paris, France,... Intelligent Agents V: Agents Theories, Architectures, and Languages - 5th International Workshop, ATAL'98, Paris, France, July 4-7, 1998, Proceedings (Paperback, 1999 ed.)
Joerg Muller, Munindar P. Singh, Anand S. Rao
R1,779 Discovery Miles 17 790 Ships in 10 - 15 working days

The leading edge of computer science research is notoriously ?ckle. New trends come and go with alarming and unfailing regularity. In such a rapidly changing ?eld, the fact that research interest in a subject lasts more than a year is worthy of note. The fact that, after ?ve years, interest not only remains, but actually continues to grow is highly unusual. As 1998 marked the ?fth birthday of the International Workshop on Agent Theories, Architectures, and Languages (ATAL), it seemed appropriate for the organizers of the original workshop to comment on this remarkable growth, and re ect on how the ?eld has developed and matured. The ?rst ATAL workshop was co-located with the Eleventh European Conference on Arti?cial Intelligence (ECAI-94), which was held in Amsterdam. The fact that we chose an AI conference to co-locate with is telling: at that time, we expected most researchers with an interest in agents to come from the AI community. The workshop, whichwasplannedoverthesummerof1993, attracted32submissions, andwasattended by 55 people.ATAL was the largest workshop at ECAI-94, and the clear enthusiasm on behalfofthecommunitymadethedecisiontoholdanotherATALworkshopsimple.The ATAL-94proceedingswereformallypublishedinJanuary1995underthetitleIntelligent Agents, and included an extensive review article, a glossary, a list of key agent systems, and - unusually for the proceedings of an academic workshop - a full subject index. Thehighscienti?candproductionvaluesembodiedbytheATAL-94proceedingsappear to have been recognized by the community, and resulted inATAL proceedings being the most successful sequence of books published in Springer-Verlag s Lecture Notes in Arti?cial Intelligence serie

Intelligent Agents III. Agent Theories, Architectures, and Languages - ECAI'96 Workshop (ATAL), Budapest, Hungary, August... Intelligent Agents III. Agent Theories, Architectures, and Languages - ECAI'96 Workshop (ATAL), Budapest, Hungary, August 12-13, 1996, Proceedings (Paperback, 1997 ed.)
Joerg Muller, Michael J Wooldridge, Nicholas R. Jennings
R1,740 Discovery Miles 17 400 Ships in 10 - 15 working days

Intelligent agents are computer systems that are capable of flexible autonomous action in dynamic, typically multi-agent domains. Over the past few years, the computer science community has begun to recognise that the technology of intelligent agents provides the key to solving a range of complex software application problems, for which traditional software engineering tools and techniques offer no solution.
This book, the third in a series, represents the state of the art in the science of agent systems. It is based on papers presented at the 3rd workshop on Agent Theories, Architectures and Languages (ATAL'96), held in conjunction with the European Conference on Artificial Intelligence (ECAI'96) in Budapest, Hungary, in August 1996. It is essential reading for anyone interested in this vital new technology.

Intelligent Agents II: Agent Theories, Architectures, and Languages - IJCAI'95-ATAL Workshop, Montreal, Canada, August... Intelligent Agents II: Agent Theories, Architectures, and Languages - IJCAI'95-ATAL Workshop, Montreal, Canada, August 19-20, 1995 Proceedings (Paperback, 1996 ed.)
Michael Wooldridge, Joerg Muller, Milind Tambe
R1,760 Discovery Miles 17 600 Ships in 10 - 15 working days

This book is based on the second International Workshop on Agent Theories, Architectures, and Languages, held in conjunction with the International Joint Conference on Artificial Intelligence, IJCAI'95 in Montreal, Canada in August 1995.
The 26 papers are revised final versions of the workshop presentations selected from a total of 54 submissions; also included is a comprehensive introduction, a detailed bibliography listing 355 relevant publications, and a subject index. The book is structured into seven sections, reflecting the most current major directions in agent-related research. Together with its predecessor, Intelligent Agents, published as volume 890 in the LNAI series, this book provides a timely and comprehensive state-of-the-art report.

Enterprise Interoperability - New Challenges and Approaches (Hardcover, 2007 ed.): Guy Doumeingts, Joerg Muller, Gerard Morel,... Enterprise Interoperability - New Challenges and Approaches (Hardcover, 2007 ed.)
Guy Doumeingts, Joerg Muller, Gerard Morel, Bruno Vallespir
R6,137 Discovery Miles 61 370 Ships in 10 - 15 working days

Composed of over 50 papers, "Enterprise Interoperability" ranges from academic research through case studies to industrial and administrative experience of interoperability. The international nature of the authorship continues to broaden. Many of the papers have examples and illustrations calculated to deepen understanding and generate new ideas. This is a concise reference to the state-of-the-art in software interoperability.

Multiagent based Supply Chain Management (Hardcover, 2006 ed.): Brahim Chaib-Draa, Joerg Muller Multiagent based Supply Chain Management (Hardcover, 2006 ed.)
Brahim Chaib-Draa, Joerg Muller
R4,779 Discovery Miles 47 790 Ships in 10 - 15 working days

This book takes a close look at recent progress in the field of supply chain management using agent technology and more specifically multiagent systems. Sixteen chapters are organized in four main parts: Introductory Papers; Multiagent Based Supply Chain Modeling; Collaboration and Coordination Between Agents in a Supply Chain; and Multiagent Based Supply Chain Management: Applications. The result is a comprehensive review of existing literature, and ideas for future research.

Multiagent System Technologies - First German Conference, MATES 2003, Erfurt, Germany, September 22-25, 2003, Proceedings... Multiagent System Technologies - First German Conference, MATES 2003, Erfurt, Germany, September 22-25, 2003, Proceedings (Paperback, 2003 ed.)
Michael Schillo, Matthias Klusch, Joerg Muller, Huaglory Tianfield
R1,624 Discovery Miles 16 240 Ships in 10 - 15 working days

ThesearetheproceedingsoftheGermanconferenceonMultiagentSystemTe- nologies(MATES2003), whichwasthe?rstconferenceorganizedbytheGerman specialinterestgrouponDistributedArti?cialIntelligencetopromotethetheory and application of agents and multiagent systems. Its goals were to cover the whole range from the theory to applications of agent and multiagent technology and re?ect the national and international state of the art. The conference p- vided an excellent interdisciplinary forum for both researchers and members of business and industry to present and discuss the latest advances in theoretical work on and prototyped or ?elded systems of intelligent agents. Building on the sequence of agent-related events in Germany in the past, such as VDI 1998 (Chemnitz), VertIS 2001 (Bamberg), and KI 2002 (Aachen), MATES 2003 was exclusively devoted to agents and multiagent systems, and the cro- fertilization between agent theory and application. In addition, it built on the success of the past international workshop on "Agent Technology and Software Engineering (AgeS 2002)," and the international symposium on "Multiagent Systems, LargeComplexSystems, andE-Businesses"(MALCEB2002).MATES 2003 was co-located with the fourth international Net.ObjectDays conference in an exciting event held in Erfurt during September 22-24. The MATES 2003 conference featured a sequence of regular and invited talks of excellence given by leading experts in the ?eld. Among these were two k- notes, an invited talk and 18 paper presentations selected from 49 submissions.

Advances on Practical Applications of Agents and Multi-Agent Systems - 10th International Conference on Practical Applications... Advances on Practical Applications of Agents and Multi-Agent Systems - 10th International Conference on Practical Applications of Agents and Multi-Agent Systems (Paperback, 2012 ed.)
Yves Demazeau, Joerg Muller, Juan M. Corchado Rodriguez, Javier Bajo Perez
R5,763 Discovery Miles 57 630 Ships in 10 - 15 working days

Research on Agents and Multi-Agent Systems has matured during the last decade and many effective applications of this technology are now deployed. PAAMS provides an international forum to present and discuss the latest scientific developments and their effective applications, to assess the impact of the approach, and to facilitate technology transfer. PAAMS started as a local initiative, but has since grown to become THE international yearly platform to present, to discuss, and to disseminate the latest developments and the most important outcomes related to real-world applications. It provides a unique opportunity to bring multi-disciplinary experts, academics and practitioners together to exchange their experience in the development and deployment of Agents and Multi-Agent Systems. PAAMS intends to bring together researchers and developers from industry and the academic world to report on the latest scientific and technical advances on the application of multi-agent systems, to discuss and debate the major issues, and to showcase the latest systems using agent based technology. It will promote a forum for discussion on how agent-based techniques, methods, and tools help system designers to accomplish the mapping between available agent technology and application needs. Other stakeholders should be rewarded with a better understanding of the potential and challenges of the agent-oriented approach.

This edition of PAAMS brings together past experience, current work, and promising future trends associated with distributed computing, artificial intelligence and their application in order to provide efficient solutions to real problems. This symposium is organized by the Bioinformatics, Intelligent System and Educational Technology Research Group (http: //bisite.usal.es/) of the University of Salamanca. The present edition will be held in Salamanca, Spain, from 28th to 30th March 2012.

This edition of PAAMS brings together past experience, current work, and promising future trends associated with distributed computing, artificial intelligence and their application in order to provide efficient solutions to real problems. This symposium is organized by the Bioinformatics, Intelligent System and Educational Technology Research Group (http: //bisite.usal.es/) of the University of Salamanca. The present edition will be held in Salamanca, Spain, from 28th to 30th March 2012.

Das Recht Der Versicherungsvermittlung (German, Paperback, 2nd 2. Aufl. 1997 ed.): Joerg Muller-Stein Das Recht Der Versicherungsvermittlung (German, Paperback, 2nd 2. Aufl. 1997 ed.)
Joerg Muller-Stein
R1,613 Discovery Miles 16 130 Ships in 10 - 15 working days
Aufruf zum Umdenken (German, Paperback): Joerg Muller Aufruf zum Umdenken (German, Paperback)
Joerg Muller
R608 Discovery Miles 6 080 Ships in 10 - 15 working days
Struktur- und Funktionsanaloga der Cu, Zn-Superoxid-Dismutase (German, Paperback): Joerg Muller Struktur- und Funktionsanaloga der Cu, Zn-Superoxid-Dismutase (German, Paperback)
Joerg Muller
R4,624 R4,229 Discovery Miles 42 290 Save R395 (9%) Ships in 10 - 15 working days

Doktorarbeit / Dissertation aus dem Jahr 1997 im Fachbereich Chemie - Biochemie, Note: 1,0, Eberhard-Karls-Universitat Tubingen (Unbekannt), Sprache: Deutsch, Abstract: Inhaltsangabe: Zusammenfassung: Neun neue Kupfer-Di-Schiff-Basen-Komplexe wurden erstmals synthetisiert und mit der Reaktivitat bekannter Komplexe wie Cu(II)PuPy](ClO4)2, Cu(II)PuACPy] ](ClO4)2 und Cu(II)(phen)2]Cl2 verglichen. Alle Komplexe wurden chemisch und spektroskopisch (UV/Vis, ESR, AAS, IR) charakteri-siert. Von funf Kupfer-Di-Schiff-Basen gelang es Einkristalle zu isolieren und Kristall-strukturen aus Rontgenbeugungsdaten zu berechnen. Bezuglich der physikochemischen Eigenschaften kommt Cu(II)PuPhePy](ClO4)2 der Cu, Zn-Superoxid-Dismutase (SOD) am nachsten. Auch die Kristallstruktur zeigt eine dem aktiven Zentrum der SOD sehr ahnliche Koordinationsgeometrie des Kupfers. Fur den SOD-aktivsten der Komplexe, Cu(II)PuPhePy](ClO4)2, wurde im Nitrotetrazolium-blau Test mit einer Halbwertshemmkonzentration (IC50) von 0,27 uM 3 % der Aktivitat des Enzyms gemessen. Der Komplex reagiert mit pulsradiolytisch erzeugtem Superoxid in Gegenwart eines vierfachen Uberschusses an EDTA mit einer Geschwindigkeit von k2 = 0,48 x 109 M-1 s-1 und liegt damit in der gleichen Grossenordnung wie intakte Cu, Zn-SOD. Die thermodynamische Stabilitat ist mit log K von 18,33 bei pH 7 um zwei Grossenordnungen hoher als die von Cu(II)EDTA oder Cu(II)Serumalbumin. Damit ist Cu(II)PuPhePy](ClO4)2 nicht nur einer der aktivsten SOD Funktions- und Strukturanaloga, sondern er ist auch gegen Hydrolyse bei pH 5 - 8 und gegenuber kompetitiven Biochelatoren ausserordentlich stabil. Neben der SOD-Aktivitat ist Cu(II)PuPhePy](ClO4)2 membrangagngig, Fenton-aktiv und spaltet DNA in vitro mit einer ahnlichen Reaktivitat wie Cu(II)(phen)2]Cl2, eine der effektivsten Nuklease-mimetischen Verbindungen. Der Komplex ist bezuglich Interkalation und Oxidation von DNA im Ames Test in vivo nicht mutagen und im Blut gegenuber Serumalbumin s

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