Presenting recent applications in clinical development, pharmacokinetic/ pharmacodynamic modeling, and clinical trial simulation, this in-depth reference studies the role of biomarkers in successful drug formulation and development-utilizing the latest discoveries in biomarker science to determine the safety and efficacy of emerging drug compounds.

"Most of the contributions strongly project the authors' perceptions of the role of race on their subjects, and essays should elicit lively discussions in the classroom."
--"CHOICE"

Frederick Douglass liked to say of West Indian boxer Peter Jackson that "Peter is doing a great deal with his fists to solve the Negro question." His comment reflects the possibilities for social transformation that he saw in the emerging modern sports culture. Indeed, as the twentieth century developed, sports have become an important cultural terrain over which various racial groups have contested, defined, and represented their racial, national, and inter-ethnic identities.

Sports Matters brings critical attention to the centrality of race within the politics and pleasures of the massive sports culture that developed in the U.S. during the past century and a half. The contributors collected here address such issues as popular representations of blacks in sports. They consider baseball--from Nisei players in Oregon to Mexican-Americans in Los Angeles. And they look at the use of warrior imagery in representations of Native American athletes and the evolution of black expressive style within basketball.

Sports Matters challenges our presumptions about sports, illuminating in the process the complexities of race and gender as they relate to popular culture.

Contributors include Amy Bass, John Bloom, Annie Gilbert Coleman, Gena Caponi, Montye Fuse, Randy Hanson, Michiko Hase, George Lipsitz, Keith Miller, Sharon O'Brien, Connie Razza, Sam Regalado, Greg Rodriguez, Julio Rodriguez, Michael Willard, and Henry Yu.

In the early 1990s, Motorola, the legendary American radio and telecom company, made a huge gamble on a revolutionary satellite telephone system called Iridium. Light-years ahead of anything previously put into space, built on technology for Ronald Reagan's "Star Wars," Iridium was a mind-boggling technical accomplishment that sent waves of panic through phone companies around the world, because, surely, Iridium was the future of communication. Only months after launching service, bankruptcy was inevitable the largest to that point in American history. It looked like Iridium would go down as just a "science experiment." That is, until Dan Colussy got a wild idea. Colussy, a retired former President of Pan Am, heard about Motorola's plans to "de-orbit" the system and decided he would try to buy Iridium. Somehow, the little guy figured he could turn around one of the biggest blunders in the history of business. Eccentric Orbits masterfully traces the development of satellite technology, the birth of Iridium, and Colussy's tireless efforts to stop it from being destroyed, despite having doors slammed in his face by all of Wall Street. Piecing together funding from a motley group of investors that included a mysterious Arab prince and friends of Jesse Jackson, he eventually made his case before the most powerful people at the Clinton White House, the Pentagon, the FCC, intelligence services, and a consortium of thirty banks, pleading for the only phone that works at the ends of earth. Eccentric Orbits is a rollicking, unforgettable tale of innovation, failure, the military-industrial complex, and one of the greatest deals of all time.

The "fascinating" true story behind the HBO Max and Hulu series about Texas housewife Candy Montgomery and the bizarre murder that shocked a community (Los Angeles Times Book Review). Candy Montgomery and Betty Gore had a lot in common: They sang together in the Methodist church choir, their daughters were best friends, and their husbands had good jobs working for technology companies in the north Dallas suburbs known as Silicon Prairie. But beneath the placid surface of their seemingly perfect lives, both women simmered with unspoken frustrations and unanswered desires. On a hot summer day in 1980, the secret passions and jealousies that linked Candy and Betty exploded into murderous rage. What happened next is usually the stuff of fiction. But the bizarre and terrible act of violence that occurred in Betty's utility room that morning was all too real. Based on exclusive interviews with the Gore and Montgomery families, Edgar Award finalist Evidence of Love is the "superbly written" account of a gruesome tragedy and the trial that made national headlines when the defendant entered the most unexpected of pleas: not guilty by reason of self-defense (Fort Worth Star-Telegram). Adapted into the Emmy and Golden Globe Award-winning television movie A Killing in a Small Town-as well as the new limited series Candy on Hulu and Love and Death on HBO Max-this chilling tale of sin and savagery will "fascinate true crime aficionados" (Kirkus Reviews).

In the early 1990s, Motorola, the legendary American company, made a huge gamble on a revolutionary satellite telephone system called Iridium. Light-years ahead of anything previously put into space, and built on technology developed for Ronald Reagan's 'Star Wars,' Iridium's constellation of sixty-six satellites in six evenly spaced orbital planes meant that at least one satellite was always overhead. Iridium was a mind-boggling technical accomplishment, surely the future of communication. The only problem was that Iridium was also a commercial disaster. Only months after launching service, it was $11 billion in debt, burning through $100 million a month and bringing in almost no revenue. Bankruptcy was inevitable - the largest to that point in American history. It looked like Iridium would go down as just a 'science experiment.' That is, until Dan Colussy got a wild idea. Colussy, a former CEO of Pan Am, heard about Motorola's plans to 'de-orbit' the system and decided he would buy Iridium and somehow turn around one of the biggest blunders in the history of business. Eccentric Orbits masterfully traces the birth of Iridium and Colussy's tireless efforts to stop it from being destroyed, from meetings with his motley investor group, to the Clinton White House, to the Pentagon, to the hunt for customers in special ops, shipping, aviation, mining, search and rescue. Impeccably researched and wonderfully told, Eccentric Orbits is a rollicking, unforgettable tale of technological achievement, business failure, the military-industrial complex and one of the greatest deals of all time.

With more than 100 vintage photographs. Nothing in the history of Ft Lauderdale had greater impact in its prosperity, than the Naval Air Station (NASFL) established in 1942. Recognizing this fact, the Naval Air Station Fort Lauderdale Historical Association can be traced to one man: Allan McElhiney a former WWII sailor who devoted much of his life to preserve a part of history. When the war ended the base closed its doors. Progress was about to eradicate the past to make way for a new Airport, but thanks to the long fight of a visionary man who saw the significance of safeguarding a bygone era, a Naval Museum was established. Flight 19 is one of the great aviation mysteries. It flew out of NASFL in 1945 to vanish into the Bermuda Triangle. In addition, a 19 year old future US President lived at NASFL as a young Ensign to train as a torpedo/bomber pilot. This is the inspirational story of one man who's commitment to the cause of preservation has encouraged many to look into our past, to safeguard our future.

Barry Bonds has emerged, statistically, as the most feared hitter since Babe Ruth. Bonds, winner of a record six MVP awards, holds the single-season record for home-runs, slugging percentage, on-base percentage, and walks, and is the only player ever to have hit 500 home-runs and stolen 500 bases. His statistical performance is beyond reproach, but his public image remains controversial, and recent allegations of steroid use have cast a shadow over his unprecedented accomplishments. This timely book strips away the hype and takes an objective look and Bonds' life and career.

It has been said that hitting a baseball is the hardest thing to do in professional sports. "Baseball's All-Time Greatest Hitters" presents biographies on Greenwood's selection for the 12 best hitters in Major League history, written by some of today's best baseball authors. These books present straightforward stories in accessible language for the high school researcher and the general reader alike. Each volume includes a timeline, bibliography, and index. In addition, each volume includes a Making of a Legend chapter that analyses the evolution of the player's fame and (in some cases) infamy.

"Most of the contributions strongly project the authors' perceptions of the role of race on their subjects, and essays should elicit lively discussions in the classroom."
--"CHOICE"

Frederick Douglass liked to say of West Indian boxer Peter Jackson that "Peter is doing a great deal with his fists to solve the Negro question." His comment reflects the possibilities for social transformation that he saw in the emerging modern sports culture. Indeed, as the twentieth century developed, sports have become an important cultural terrain over which various racial groups have contested, defined, and represented their racial, national, and inter-ethnic identities.

Sports Matters brings critical attention to the centrality of race within the politics and pleasures of the massive sports culture that developed in the U.S. during the past century and a half. The contributors collected here address such issues as popular representations of blacks in sports. They consider baseball--from Nisei players in Oregon to Mexican-Americans in Los Angeles. And they look at the use of warrior imagery in representations of Native American athletes and the evolution of black expressive style within basketball.

Sports Matters challenges our presumptions about sports, illuminating in the process the complexities of race and gender as they relate to popular culture.

Contributors include Amy Bass, John Bloom, Annie Gilbert Coleman, Gena Caponi, Montye Fuse, Randy Hanson, Michiko Hase, George Lipsitz, Keith Miller, Sharon O'Brien, Connie Razza, Sam Regalado, Greg Rodriguez, Julio Rodriguez, Michael Willard, and Henry Yu.

Explores the connection between baseball card collecting and nostalgia among men of the baby boom.

"Collectors often decried how money had ruined their hobby, making it hard for them to form meaningful friendships through their cards. Money, however, made the hobby not only profitable but also more serious, more instrumental, and therefore more manly. The same collectors who complained about greed often bragged in the same interview about the value of their cards. Yet money, in turn, made the hobby less akin to child's play and more like work: lonely, competitive, unfulfilling, and alienating".

Baseball card collecting carries with it images of idealized boyhoods in the sprawling American suburbs of the postwar era. Yet in the past twenty years, it has grown from a pastime for children to a big-money pursuit taken seriously by adults. In A House of Cards, John Bloom uses interviews with collectors, dealers, and hobbyists as well as analysis of the baseball card industry and extensive firsthand observations to ask what this hobby tells us about nostalgia, work, play, masculinity, and race and gender relations among collectors.

Beginning in the late 1970s and into the early 1990s, baseball card collecting grew into a business that embodied traditional masculine values such as competition, savvy, and industry. In A House of Cards, Bloom interviews collectors who reveal ambivalence about the hobby's emphasis on these values, often focusing on its alienating, lonely, and unfulfilling aspects. They express nostalgia for the ideal childhood world many middle-class white males experienced in the postwar years, when they perceived baseball card collecting as a form of play, not amoneymaking enterprise.

Bloom links this nostalgia to anxieties about deindustrialization and the rise of the civil rights, feminist, and gay rights movements. He examines the gendered nature of swap meets as well as the views of masculinity expressed by the collectors: Is the purpose of baseball card collecting to form a community of adults to reminisce or to inculcate young men with traditional masculine values? Is it to establish "connectedness" or to make money? Are collectors striving to reinforce the dominant culture or question it through their attempts to create their own meaning out of what are, in fact, mass-produced commercial artifacts?

Bloom provides a fascinating exploration of male fan culture, ultimately providing insight into the ways white men of the baby boom view themselves, masculinity, and the culture at large.