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Gun (DVD): 50 Cent, Val Kilmer, Hassan Johnson, John Larroquette, Michael Matthias, James Remar, Mark Famiglietti, Annalynne... Gun (DVD)
50 Cent, Val Kilmer, Hassan Johnson, John Larroquette, Michael Matthias, … 1
R39 Discovery Miles 390 Ships in 10 - 20 working days

Crime drama starring rapper 50 Cent (aka Curtis Jackson) as a weapons dealer who is under investigation by the FBI. Rich (Jackson) is in the middle of a gun deal gone wrong when ex-con Angel (Val Kilmer), who is working for the cops to get inside information on Rich's crew, saves his life. However, when Rich's lover and weapons supplier, Gabriella (AnnaLynne McCord) begins to get suspicious and is caught in the middle of a shoot-up herself, things look set to turn ugly.

The Principles of Morals Volume 2 (Paperback): Wilson John Matthias The Principles of Morals Volume 2 (Paperback)
Wilson John Matthias
R554 Discovery Miles 5 540 Ships in 12 - 17 working days

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Venerable Mother M. Caroline Friess, First Commissary General of the School Sisters of Notre Dame in America - a Sketch of Her... Venerable Mother M. Caroline Friess, First Commissary General of the School Sisters of Notre Dame in America - a Sketch of Her Life and Character (Hardcover)
P M (Peter Matthias) 1843 Abbelen, John Lancaster Abp Spalding, School Sisters of Notre Dame
R885 Discovery Miles 8 850 Ships in 12 - 17 working days
The Man with the Book (Hardcover): John Matthias Weylland The Man with the Book (Hardcover)
John Matthias Weylland
R1,327 Discovery Miles 13 270 Ships in 10 - 15 working days
Swimming at Midnight - Selected Shorter Poems (Paperback, 1): John Matthias Swimming at Midnight - Selected Shorter Poems (Paperback, 1)
John Matthias
R476 R450 Discovery Miles 4 500 Save R26 (5%) Ships in 12 - 17 working days

Swimming at Midnight collects the short and middle-length poems from John Matthias's earlier books together with twenty poems that have previously appeared only in magazines. It is published simultaneously with Beltane at Aphelion, which includes all of Matthias's longer poems. The two books together represent some thirty years of his work. The poems in Swimming at Midnight range from early lyrics written in American during the late 1960s to meditative poems dealing with historical, geographical and cultural themes deriving from Matthias's years in England in the seventies and eighties; they include the epistolary poems from Turns, "Poem for Cynouai" from Crossing, "A Wind in Roussillon" from Northern Summer, and the formal experiments engaging issues of poetics and metaphysics for which Matthias is well known. The book concludes with a section of new poems and translations dealing both with the public world of modern history and the private experience of life in the century's final decade. The last poem of all connects the work in Swimming at Midnight with the last of the long poems in Beltane at Aphelion. Critics have been warm in their praise of Matthias's work. Robert Duncan called his early poetry "the work of a Goliard-one of those wandering souls out of a Dark Age in our own time," and Guy Davenport has said that his recent work makes him "one of the leading poets in the USA." D. M. Thomas in the TLS admired the "virtuosity" of Turns and the way "life presses into the poems," while John Fuller in the same journal found the poems in Crossing "bursting with a masterful intelligence." In a long essay on Northern Summer, Jeremy Hooker wrote: "In his combination of lyrical and discursive voices, as in subject and concern, Matthias has an exciting range...He writes in some poems from a tension between a scribe's respect for the integrity of his materials and a magician's freedom to transform them, and in many poems he brings together the contrasting gifts and is fully present as himself, both scribe and magician."

Round the Tower [microform]; or the Story of the London City Mission (Hardcover): John Matthias Weylland Round the Tower [microform]; or the Story of the London City Mission (Hardcover)
John Matthias Weylland
R885 Discovery Miles 8 850 Ships in 12 - 17 working days
Biohydrogen (Hardcover): Matthias Roegner Biohydrogen (Hardcover)
Matthias Roegner; Contributions by Amanda Applegate, Sarah D'Adamo, Ulrich Ermler, Barbel Friedrich, …
R4,395 Discovery Miles 43 950 Ships in 12 - 17 working days

Biohydrogen is considered the most promising energy carrier and its utilization for energy storage is a timely technology. This book presents latest research results and strategies evolving from an international research cooperation, discussing the current status of Biohydrogen research and picturing future trends and applications.

Contemporary Debates in Epistemology (3rd edition): Matthias Steup, Blake Roeber, John Turri, Ernest Sosa Contemporary Debates in Epistemology (3rd edition)
Matthias Steup, Blake Roeber, John Turri, Ernest Sosa
R1,186 R1,115 Discovery Miles 11 150 Save R71 (6%) Ships in 12 - 17 working days
Pseudomonas syringae and related pathogens - Biology and Genetic (Hardcover, 2004 ed.): Nicola Sante Iacobellis, Alan Collmer,... Pseudomonas syringae and related pathogens - Biology and Genetic (Hardcover, 2004 ed.)
Nicola Sante Iacobellis, Alan Collmer, Steven W. Hutcheson, John W. Mansfield, Cindy E. Morris, …
R5,763 Discovery Miles 57 630 Ships in 10 - 15 working days

This volume mainly reports on new and recent advancements on different aspects of Pseudomonas syringae, a plant pathogenic bacterial species that include a high number of pathogens of important crops, which is an interesting model organism in plant pathology. In addition some related fluorescent Pseudomonas spp., responsible of new and emerging diseases, as well as some pathogens previously included in the above genus and now classified in the genera Ralstonia, Acidovorax are also considered. The tremendous recent advancements on: the ecology and epidemiology and, in particular, the adaptation of P. syringae to stresses and adverse environmental conditions; the function and regulation of genes involved in the production of phytotoxins and on their mechanism of action in the interaction with the host cells; the structure, function and regulation of type three secretion system (TTSS) and the transport of the effectors proteins in the host cells; the possibility to control diseases through the induction of the systemic acquired resistance (SAR); the development of molecular techniques for the highly specific and sensible identification and detection of pathogens; the determination of the causal agents of new and emerging diseases as well the classification of the different pathovars of P. syringae; are reported in 76 chapters cured by leading scientist in the respective fields.

Phosphoinositides II: The Diverse Biological Functions (Hardcover, 2012 ed.): Tamas Balla, Matthias Wymann, John D. York Phosphoinositides II: The Diverse Biological Functions (Hardcover, 2012 ed.)
Tamas Balla, Matthias Wymann, John D. York
R6,392 Discovery Miles 63 920 Ships in 10 - 15 working days

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.

Phosphoinositides I: Enzymes of Synthesis and Degradation (Hardcover, 2012 ed.): Tamas Balla, Matthias Wymann, John D. York Phosphoinositides I: Enzymes of Synthesis and Degradation (Hardcover, 2012 ed.)
Tamas Balla, Matthias Wymann, John D. York
R5,690 R4,384 Discovery Miles 43 840 Save R1,306 (23%) Ships in 12 - 17 working days

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Policy Transfer, New Public Management and Globalization - Mexico and the Caribbean (Paperback, New edition): Ann Marie... Policy Transfer, New Public Management and Globalization - Mexico and the Caribbean (Paperback, New edition)
Ann Marie Bissessar; Contributions by Tyrone Ferguson, Pol Herrmann, John Gaffar La Guerre, Patrick Kent Watson, …
R1,545 Discovery Miles 15 450 Ships in 12 - 17 working days

The more recent experiments with New Public Management, in various countries, have revealed that there were major differences among what a number of writers referred to as 'differential application' of systems and practices. It was suggested that these differences were a result of environmental considerations. But the major preoccupation of the earlier literature on New Public Management was with debates on whether the systems and practices of New Public Management had achieved success in the developed countries. Unfortunately, developing countries such as Mexico and countries in the Caribbean are largely neglected in the current literature. Policy Transfer, New Public Management and Globalization fills this gap. Focusing on policy transfer, new public management, and globalization, the contributors examine the problems and difficulties in introducing and implementing policies in small, plural, politically unstable societies.

Vielfalt in der öffentlichen Verwaltung - Strategien und Konzepte für ein wirksames Diversity Management in Kommunen,... Vielfalt in der öffentlichen Verwaltung - Strategien und Konzepte für ein wirksames Diversity Management in Kommunen, Ländern und Bund (1. Aufl. 2023)
John Meister, Matthias Hörmeyer
R1,928 Discovery Miles 19 280 Ships in 10 - 15 working days

Dieses Buch zeigt, wie Diversity Management in der öffentlichen Verwaltung gelingt und Vielfalt in Kommunen, Ländern und Bund erfolgreich gefördert wird. Die öffentliche Verwaltung steht vor zahlreichen Herausforderungen: Demografischer Wandel, Arbeitskräftemangel, Klimawandel, Digitalisierung, Krisenbewältigungen, veränderte Ansprüche der Gesellschaft. Eine zeitgemäße Antwort darauf ist Diversity Management. Mit Diversity kann sich die öffentliche Verwaltung zukunftsorientiert verändern. Sie kann attraktive Arbeitgeberin sein, empathischer auf die Bedürfnisse der Bürger*innen eingehen und den Herausforderungen der Zukunft besser begegnen. Renommierte Fachbeitragsautor*innen zeigen, dass Diversity wichtige Bausteine liefert, um die erforderliche Handlungsfähigkeit der öffentlichen Verwaltung nachhaltig zu sichern. Dazu werden vielfältige Konzepte, Ideen, Praxisbeispiele und Erfahrungsberichte vorgestellt, wie die öffentliche Verwaltung neue und innovative Wege gehen kann, um Diversity Management erfolgreich umzusetzen. Mit Beiträgen von:  Paula Lina Auksutat Sarina Badafras Belma Bekos Cigdem Bern Isabel Collien Sonja Dudek Irina Eckardt Dr. Klaus Effing Stefan Fuerst  Julia Göpel Prof. Dr. Regine Graml Ana-Cristina Grohnert Marc Groß Ines Hansen Tessa Hillermann Matthias Hörmeyer (Hrsg.) Hans W. Jablonski Kathleen Jäger Jana Janze Peter Janze Jan Klumb Ibrahim Köran Anika Krellmann Edwin Meier John Meister (Hrsg.) Sabine Meister Baris Önes Zehra Öztürk Melanie Peterson Maria Pozder Gabriel Rath Meike Reuter Alice Rittgerodt Magdalena Rogl Jochen Schiffmann Rouven-Alexander Slabik Magdalena Weiß Gülcan Yoksulabakan-Üstüay Christian Zierau

Warring over Valor - How Race and Gender Shaped American Military Heroism in the Twentieth and Twenty-First Centuries... Warring over Valor - How Race and Gender Shaped American Military Heroism in the Twentieth and Twenty-First Centuries (Hardcover)
Simon Wendt; Contributions by Simon Wendt, George Lewis, Ellen D. Wu, Matthias Voigt, …
R3,098 Discovery Miles 30 980 Ships in 12 - 17 working days

By focusing on how the idea of heroism on the battlefield helped construct, perpetuate, and challenge racial and gender hierarchies in the United States between World War I and the present, Warring over Valor provides fresh perspectives on the history of American military heroism. The book offers two major insights into the history of military heroism. First, it reveals a precarious ambiguity in the efforts of minorities such as African Americans, Asian Americans, Native Americans, women, and gay men to be recognized as heroic soldiers. Paradoxically, America's heroism discourse allowed them to press their case for full membership in the nation, but doing so simultaneously validated the dichotomous interpretations of race and gender they repudiated. The ambiguous role of marginalized groups in war-related hero-making processes also testifies to this volume's second general insight: the durability and tenacity of the masculine warrior hero in U.S. society and culture. Warring over Valor bridges a gap in the historiography of heroism and military affairs.

The Jews - A History (Paperback, 3rd edition): John Efron, Matthias Lehmann, Steven Weitzman The Jews - A History (Paperback, 3rd edition)
John Efron, Matthias Lehmann, Steven Weitzman
R2,634 Discovery Miles 26 340 Ships in 9 - 15 working days

The Jews: A History is a comprehensive and accessible text that explores the religious, cultural, social, and economic diversity of the Jewish people and their faith. Placing Jewish history within its wider cultural context, the book covers a broad time span, stretching from ancient Israel to the modern day. It examines Jewish history across a range of settings, including the ancient Near East, the age of Greek and Roman rule, the medieval realms of Christianity and Islam, modern Europe, including the World Wars and the Holocaust, and contemporary America and Israel, covering a variety of topics, such as legal emancipation, acculturation, and religious innovation. The third edition is fully updated to include more case studies and to encompass recent events in Jewish history, as well as religion, social life, economics, culture, and gender. Supported by case studies, online references, further reading, maps, and illustrations, The Jews: A History provides students with a comprehensive and wide-ranging grounding in Jewish history.

John Matthias & Jay Auborn (Vinyl record): John Matthias & Jay Auborn John Matthias & Jay Auborn (Vinyl record)
John Matthias & Jay Auborn
R100 Discovery Miles 1 000 Ships in 10 - 20 working days
A Gathering of Ways (Paperback): John Matthias A Gathering of Ways (Paperback)
John Matthias
R361 R335 Discovery Miles 3 350 Save R26 (7%) Ships in 12 - 17 working days

A Gathering of Ways is John Matthias' first collection of poems since the publication of his warmly received Northern Summer collection in 1985. The book consists of three long poems dealing with the geography, geology, prehistory, and history of two places closely identified with Matthias' work, the East Anglian region of Britain and the American Midwest, and a third place that provides the book with a new and deeply resonant setting: those parts of southern France and northern Spain through which run the famous pilgrimage routes to Santiago de Compostela. \u201cAn East Anglian Diptych\u201d explores those parts of Cambridgeshire, Suffolk, and Norfolk linked by three rivers and by those ancient paths and tracks known as ley lines which connect locality and locality and time with time. \u201cFacts From an Apocryphal Midwest\u201d explores another group of trails that began as prehistoric paths down which copper from Lake Superior was carried from the early days of the mound-builders. Despite the historical backdrop of these poems, both bring the reader into the present in unexpected ways, preparing him or her for the strange and visionary \u201cA Compostela Diptych,\u201d winner of the Poetry Society of America's George Bogin Memorial Award.

Advanced Information Systems Engineering - 26th International Conference, CAiSE 2014, Thessaloniki, Greece, June 16-20, 2014,... Advanced Information Systems Engineering - 26th International Conference, CAiSE 2014, Thessaloniki, Greece, June 16-20, 2014, Proceedings (Paperback, 2014 ed.)
Matthias Jarke, John Mylopoulos, Christoph Quix, Colette Rolland, Yannis Manolopoulos, …
R1,626 Discovery Miles 16 260 Ships in 10 - 15 working days

This book constitutes the proceedings of 26th International Conference on Advanced Information Systems Engineering, CAiSE 2014, held in Thessaloniki, Greece in June 2014. The 41 papers and 3 keynotes presented were carefully reviewed and selected from 226 submissions. The accepted papers were presented in 13 sessions: clouds and services; requirements; product lines; requirements elicitation; processes; risk and security; process models; data mining and streaming; process mining; models; mining event logs; databases; software engineering.

Phosphoinositides I: Enzymes of Synthesis and Degradation (Paperback, 2012 ed.): Tamas Balla, Matthias Wymann, John D. York Phosphoinositides I: Enzymes of Synthesis and Degradation (Paperback, 2012 ed.)
Tamas Balla, Matthias Wymann, John D. York
R4,361 Discovery Miles 43 610 Ships in 10 - 15 working days

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Phosphoinositides II: The Diverse Biological Functions (Paperback, 2012 ed.): Tamas Balla, Matthias Wymann, John D. York Phosphoinositides II: The Diverse Biological Functions (Paperback, 2012 ed.)
Tamas Balla, Matthias Wymann, John D. York
R5,870 Discovery Miles 58 700 Ships in 10 - 15 working days

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.

AA Bronson: AA Bronson's House of Shame (Hardcover): A.A. Bronson AA Bronson: AA Bronson's House of Shame (Hardcover)
A.A. Bronson; Edited by Vincent Simon; Text written by Philip Aarons, Defne Ayas, Elijah Burger, …
R1,028 Discovery Miles 10 280 Ships in 12 - 17 working days
Computer Animation Complete - All-in-One: Learn Motion Capture, Characteristic, Point-Based, and Maya Winning Techniques... Computer Animation Complete - All-in-One: Learn Motion Capture, Characteristic, Point-Based, and Maya Winning Techniques (Paperback)
Rick Parent, David S. Ebert, David Gould, Markus Gross, Chris Kazmier, …
R1,688 R1,569 Discovery Miles 15 690 Save R119 (7%) Ships in 12 - 17 working days

A compilation of key chapters from the top MK computer animation books available today - in the areas of motion capture, facial features, solid spaces, fluids, gases, biology, point-based graphics, and Maya. The chapters provide CG Animators with an excellent sampling of essential techniques that every 3D artist needs to create stunning and versatile images. Animators will be able to master myriad modeling, rendering, and texturing procedures with advice from MK's best and brightest authors.

Divided into five parts (Introduction to Computer Animation and Technical Background, Motion Capture Techniques, Animating Substances, Alternate Methods, and Animating with MEL for MAYA), each one focusing on specific substances, tools, topics, and languages, this is a MUST-HAVE book for artists interested in proficiency with the top technology available today Whether you're a programmer developing new animation functionality or an animator trying to get the most out of your current animation software, Computer Animation Complete: will help you work more efficiently and achieve better results. For programmers, this book provides a solid theoretical orientation and extensive practical instruction information you can put to work in any development or customization project. For animators, it provides crystal-clear guidance on determining which of your concepts can be realized using commercially available products, which demand custom programming, and what development strategies are likely to bring you the greatest success.
Expert instruction from a variety of pace-setting computer graphics researchers.Provides in-depth coverage of established and emerging animation algorithms.For readers who lack a strong scientific background, introduces the necessary concepts from mathematics, biology, and physics.A variety of individual languages and substances are addressed, but addressed separately - enhancing your grasp of the field as a whole while providing you with the ability to identify and implement solutions by category.

The Jews - A History (Hardcover, 3rd edition): John Efron, Matthias Lehmann, Steven Weitzman The Jews - A History (Hardcover, 3rd edition)
John Efron, Matthias Lehmann, Steven Weitzman
R4,713 Discovery Miles 47 130 Ships in 12 - 17 working days

The Jews: A History is a comprehensive and accessible text that explores the religious, cultural, social, and economic diversity of the Jewish people and their faith. Placing Jewish history within its wider cultural context, the book covers a broad time span, stretching from ancient Israel to the modern day. It examines Jewish history across a range of settings, including the ancient Near East, the age of Greek and Roman rule, the medieval realms of Christianity and Islam, modern Europe, including the World Wars and the Holocaust, and contemporary America and Israel, covering a variety of topics, such as legal emancipation, acculturation, and religious innovation. The third edition is fully updated to include more case studies and to encompass recent events in Jewish history, as well as religion, social life, economics, culture, and gender. Supported by case studies, online references, further reading, maps, and illustrations, The Jews: A History provides students with a comprehensive and wide-ranging grounding in Jewish history.

Inborn Metabolic Diseases - Diagnosis and Treatment (Hardcover, 7th ed. 2022): Jean-Marie Saudubray, Matthias R. Baumgartner,... Inborn Metabolic Diseases - Diagnosis and Treatment (Hardcover, 7th ed. 2022)
Jean-Marie Saudubray, Matthias R. Baumgartner, Angeles Garcia-Cazorla, John Walter
R6,856 Discovery Miles 68 560 Ships in 12 - 17 working days

This 7th edition is a milestone in the series of Inborn Metabolic Diseases (IMD), recognised as the standard textbook for professionals involved in the diagnosis and management of IMD. Within the last 5 years a Copernican revolution in our understanding of IMD has changed the definition, concepts, paradigms, and classification. This new edition now extends the concept of IMD to include those disturbances in molecular machinery diagnosed by molecular techniques but currently without measurable metabolic markers. The book presents a clinical and biochemical approach to the diagnosis and management of IEM with many diagnostic algorithms for patients of all ages and with a particular focus on neurological presentations. It includes separate, comprehensive sections on IEM classified in 3 major pathophysiological categories: disorders of energy metabolism, both mitochondrial and non-mitochondrial; small molecule disorders, mostly diagnosed with metabolic markers; and complex molecules disorders, mostly diagnosed with molecular techniques. Two new chapters were added, describing around 600 disorders of nucleic acid metabolism, tRNA metabolism, ribosomal biogenesis, and cellular trafficking.

Inborn Metabolic Diseases - Diagnosis and Treatment (7th ed. 2022): Jean-Marie Saudubray, Matthias R. Baumgartner, Ángeles... Inborn Metabolic Diseases - Diagnosis and Treatment (7th ed. 2022)
Jean-Marie Saudubray, Matthias R. Baumgartner, Ángeles García-Cazorla, John Walter
R5,810 Discovery Miles 58 100 Ships in 10 - 15 working days

This 7th edition is a milestone in the series of Inborn Metabolic Diseases (IMD), recognised as the standard textbook for professionals involved in the diagnosis and management of IMD. Within the last 5 years a Copernican revolution in our understanding of IMD has changed the definition, concepts, paradigms, and classification. This new edition now extends the concept of IMD to include those disturbances in molecular machinery diagnosed by molecular techniques but currently without measurable metabolic markers. The book presents a clinical and biochemical approach to the diagnosis and management of IEM with many diagnostic algorithms for patients of all ages and with a particular focus on neurological presentations. It includes separate, comprehensive sections on IEM classified in 3 major pathophysiological categories: disorders of energy metabolism, both mitochondrial and non-mitochondrial; small molecule disorders, mostly diagnosed with metabolic markers; and complex molecules disorders, mostly diagnosed with molecular techniques. Two new chapters were added, describing around 600 disorders of nucleic acid metabolism, tRNA metabolism, ribosomal biogenesis, and cellular trafficking.

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