The antipsychotic drugs are being used mainly for treatment of schizophrenia. Schizophrenia is a mental disorder characterized by a breakdown of typical emotional responses. Modified drug delivery systems (MDDS) of antipsychotics offer advantages over conventional formulations in provison of convenience, side effects and efficacy. Extended Release tablet of Antipsychotic drug were prepared using varying ratios of drug and polymers were selected for the study. After fixing the ratio of drug and polymer to control the release of drug up to desired time, the release rates were modulated by combination of two different rates controlling material. The effect of polymer concentration and channelizer concentration were studied. Drug release was observed upto 24 hrs.

The oral administration is the most convenient and commonly used method for drug delivery. Traditionally, solid oral dosage forms have been designed to release their drug load in the upper region of the gastrointestinal tract, where conditions are more suited to drug dissolutions and absorptions. Recently, greater emphasis has been placed on controlling site of drug release from oral formulations for the purposes of improving patient compliance and treatment efficiency . Many protein and peptide drugs like insulin cannot be administered through the oral route because of their degradation by the digestive enzymes of the stomach and the small intestine. Colon-specific drug delivery systems offer several potential therapeutic advantages.The opportunity to reduce adverse effects in the treatment of colonic diseases like, ulcerative colitis, colorectal cancer, Chorn's diseases and amoebiasis by topical application of drugs, active at the mucosal level The elucidation of the mode of action of some nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac (metabolized in the colon to the active moiety, sulindac sulfide) that were found to interfere with the proliferation of co

Mucoadhesive drug delivery system which utilize properties of bioadhesion of certain water-soluble polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended period of time. The mucosal layer lie a number of regions of the body including the GIT, the urogenital tract, the airways, the ear, nose, mouth and eye. The oral mucosal sites differ greatly from the one another in terms of anatomy, permeability to an applied drug and their ability to retain a delivery system for a desired length of time. The Buccal and sublingual mucosal is relatively, permeable, giving rapid absorption and acceptable bioavailability of drugs and is convenient, easily accessible and generally well accepted