Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.

The idea for this collection of essays emerged from conversations about how the art of civil discourse has become increasingly less visible in American society today, particularly in political activities. At the same time, it is frustrating to realize that more Americans vote for contestants on shows like American Idol than usually vote in the November elections. The themes throughout New York Abstains "Courteously" touch on the very heart of what it means to be a responsible citizen, both in our own country and in the global community. While so many individuals speak about values today, it ultimately seems that the true values undergirding the United States are being overshadowed by partisan politics and private ideologies. The book's contributors take a wide variety of approaches to civil discourse and civic responsibility. Each essay in this collection stands on its own and grows out of the author's unique discipline and experience. The essays, however, are the fruit of ongoing collaboration and intersect with each other in many intriguing ways.

Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.