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Ibuprofen is widely used throughout the world for a variety of
conditions. This reference work provides a comprehensive and
critical review of the basic science and clinical aspects of the
drug. The book begins with the history and development of the drug
and its current patterns of use world- wide before moving on to
examine its basic pharmaceutical attributes and medicinal
chemistry. The properties of various formulations are described
(oral prescription and OTC, topical and others) are described. The
pharmacokinetics of ibuprofen in animals and humans is discussed -
highlighting the factors affecting absorption, distribution,
metabolism and elimination. The clinical pharmacology and
toxicology and the drug's mechanisms of action in different disease
states and conditions are covered. The therapeutic uses in various
acute and inflammatory conditions is detailed. Also considered are
the safety versus efficacy issues and the pharmacoepidemiological
data.
Reviewing over a century of aspirin research and use, Aspirin and
Related Drugs provides a comprehensive source of information on the
history, chemistry, absorption in the body, therapeutic effects,
toxicology, elimination, and future uses of aspirin. Highlighting
the historical evolution of the salicylates and the commercial
development of aspirin, the book reviews the pharmacokinetics of
the salicylates, ibuprofen, and paracetamol as a basis for
understanding the biodisposition of these analgesic drugs. Leading
specialists discuss the therapeutic role of aspirin in the
prevention and treatment of thrombo-embolic diseases, its place
along with non-acetylated salicylates in the treatment of rheumatic
diseases and plain, and the potential applications for aspirin and
related drugs as prophylactics for colon cancer, Alzheimer's
disease, and vascular dementia. They also present comparisons with
other drugs used to treat pain and inflammation. With extensive
data and literature covering a broad field, this is the definitive
reference on the actions and applications of aspirin, salicylates,
and related drugs. Physicians, pharmacists, pharmacologists,
toxicologists, and chemists will find this resource useful in their
daily work. It will also be valuable to pharmaceutical companies
and researchers in the development of newer agents and novel
applications.
Ibuprofen is widely used throughout the world for a variety of
conditions. This reference work provides a comprehensive and
critical review of the basic science and clinical aspects of the
drug. The book begins with the history and development of the drug
and its current patterns of use world- wide before moving on to
examine its basic pharmaceutical attributes and medicinal
chemistry. The properties of various formulations are described
(oral prescription and OTC, topical and others) are described. The
pharmacokinetics of ibuprofen in animals and humans is discussed -
highlighting the factors affecting absorption, distribution,
metabolism and elimination. The clinical pharmacology and
toxicology and the drug's mechanisms of action in different disease
states and conditions are covered. The therapeutic uses in various
acute and inflammatory conditions is detailed. Also considered are
the safety versus efficacy issues and the pharmacoepidemiological
data.
This book brings together physicians, scientists and those
concerned with the production and use of anti-inflammatory drugs to
discuss basic issues affecting all aspects of side-effects,
including their detection and treatment. The chapters cover a wide
variety of topics including the epidemiology, clinical and
experimental aspects of side-effects in the GI tract, liver,
kidney, cartilage, bone and skin as well as the problems associated
with the newer range of disease-modifying anti-rheumatic drugs such
as methotrexate and cyclosporin. This book should be of interest to
all those who develop and use anti-inflammatory analgesic drugs,
from basic scientists to clinicians. It contains papers presented
at the Third International meeting on "Side-Effects of
Anti-inflammatory and Analgesic Drugs" held in Verona, Italy, 8-11
May 1991.
This much anticipated volume critically reviews over a century of aspirin research and use. Providing a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination and future uses of aspirin, it is the most definitive reference currently available on this drug. With chapters including the historical development of the salicylates and the commercial use of aspirin, this book also outlines the chemical properties and synthesis of aspirin, and its derivatives, developed over the last 100 years. Physicians, pharmacists, pharmacologists, toxicologists, chemists and other scientists will all find this book an invaluable insight into this popular and fascinating drug.
Providing a comprehensive and critical review of the basic science
and clinical aspects of the drug, this book covers the history and
development of the drug and its current patterns of use and
examines its basic pharmaceutical attributes and medicinal
chemistry. The author discusses the properties of various
formulations and discusses the pharmacokinetics of ibuprofen in
animals and humans--highlighting the factors affecting absorption,
distribution, metabolism, and elimination. Topics include: the
clinical pharmacology and toxicology and the drug's mechanisms of
action in different disease states and conditions, the therapeutic
uses in various acute and inflammatory conditions, and safety
versus efficacy issues and the pharmacoepidemiological data.
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