When I was asked to edit the second edition of Protein NMR Techniques, my first thought was that the time was ripe for a new edition. The past several years have seen a surge in the development of novel methods that are truly revolutionizing our ability to characterize biological macromolecules in terms of speed, accuracy, and size limitations. I was particularly excited at the prospect of making these techniques accessible to all NMR labs and for the opportunity to ask the experts to divulge their hints and tips and to write, practically, about the methods. I commissioned 19 chapters with wide scope for Protein NMR Techniques, and the volume has been organized with numerous themes in mind. Chapters 1 and 2 deal with recombinant protein expression using two organisms, E. coli and P. pastoris, that can produce high yields of isotopically labeled protein at a reasonable cost. Staying with the idea of isotopic labeling, Chapter 3 describes methods for perdeuteration and site-specific protonation and is the first of several chapters in the book that is relevant to studies of higher molecular weight systems. A different, but equally powerful, method that uses molecular biology to "edit" the spectrum of a large molecule using segmental labeling is presented in Chapter 4. Having successfully produced a high molecular weight target for study, the next logical step is data acquisition. Hence, the final chapter on this theme, Chapter 5, describes TROSY methods for stru- ural studies.

As both an academic and professional psychologist, my background is somewhat unique. Most psychologists either opt for the research route, where they study human behavior in the hope of generating insightful theories, or they choose to work clinically with clients and patients. The problems with these distinct pathways should seem appar ent. In their academic role, research psychologists study and gener ate numerous theories about people, both as individualsandas social beings. However, while their conclusions may provide the basis for therapeutic work, research psychologists are not clinicians. Con versely, clinical psychologists and other therapists are trained princi pally to work with clients and patients. While many clinicians carry out research projects, their time is mostly spent offering professional help to people. Although both roles serve to advance the science and practice of psychology, researchers in their ivory towers may find their abstract theories and conclusions are inapplicable in the "real world," whereas therapists might discover they work within pre scribed treatment frameworks without questioning the limits of these approaches. Because of my two professional roles, I have aimed to bridge this gap. Here, I have combined my experiences of researching and treat ing depression with the intentions of improving treatments and of encouraging better communication between the two psychologies. Kristina Downing-Orr Oxford, England V Acknowledgments Many people provided the inspiration for this book, and I will be etemally grateful for all their assistance."

As both an academic and professional psychologist, my background is somewhat unique. Most psychologists either opt for the research route, where they study human behavior in the hope of generating insightful theories, or they choose to work clinically with clients and patients. The problems with these distinct pathways should seem appar ent. In their academic role, research psychologists study and gener ate numerous theories about people, both as individualsandas social beings. However, while their conclusions may provide the basis for therapeutic work, research psychologists are not clinicians. Con versely, clinical psychologists and other therapists are trained princi pally to work with clients and patients. While many clinicians carry out research projects, their time is mostly spent offering professional help to people. Although both roles serve to advance the science and practice of psychology, researchers in their ivory towers may find their abstract theories and conclusions are inapplicable in the "real world," whereas therapists might discover they work within pre scribed treatment frameworks without questioning the limits of these approaches. Because of my two professional roles, I have aimed to bridge this gap. Here, I have combined my experiences of researching and treat ing depression with the intentions of improving treatments and of encouraging better communication between the two psychologies. Kristina Downing-Orr Oxford, England V Acknowledgments Many people provided the inspiration for this book, and I will be etemally grateful for all their assistance."

When I was asked to edit the second edition of Protein NMR Techniques, my first thought was that the time was ripe for a new edition. The past several years have seen a surge in the development of novel methods that are truly revolutionizing our ability to characterize biological macromolecules in terms of speed, accuracy, and size limitations. I was particularly excited at the prospect of making these techniques accessible to all NMR labs and for the opportunity to ask the experts to divulge their hints and tips and to write, practically, about the methods. I commissioned 19 chapters with wide scope for Protein NMR Techniques, and the volume has been organized with numerous themes in mind. Chapters 1 and 2 deal with recombinant protein expression using two organisms, E. coli and P. pastoris, that can produce high yields of isotopically labeled protein at a reasonable cost. Staying with the idea of isotopic labeling, Chapter 3 describes methods for perdeuteration and site-specific protonation and is the first of several chapters in the book that is relevant to studies of higher molecular weight systems. A different, but equally powerful, method that uses molecular biology to "edit" the spectrum of a large molecule using segmental labeling is presented in Chapter 4. Having successfully produced a high molecular weight target for study, the next logical step is data acquisition. Hence, the final chapter on this theme, Chapter 5, describes TROSY methods for stru- ural studies.

Chronic Fatigue Syndrome (CFS) is a common condition that can last for many years. It is a debilitating chronic illness which ruins lives. Every waking moment becomes a physical, emotional and cognitive struggle just to function on the most basic of levels. The purpose of this book is to reassure sufferers and their families that recovery is possible and that the illness is genuine. It draws on the experiences of many sufferers of chronic fatigue and on those of the author herself. Dr Kristina Downing-Orr, a clinical psychologist, suffered severe chronic fatigue symptoms and was compelled to research the cause of CFS and the cure herself because she was offered so little help by the medical profession. Her recovery was quick and lasting. In her book, Kristina reveals the causes of chronic fatigue and offers an accessible, scientifically valid, easy-to-achieve programme that will inspire people with CFS to regain their health and restore their energy and vitality. Chapters cover Kristina's own story, what chronic fatigue really is, what causes it, diagnosis, a step-by-step self-treatment programme, how to strengthen the body, and coping with stress and resources.

The Aesop's Fable Paradigm is a collection of essays that explore the cutting-edge intersection of Folklore and Science. From moralizing fables to fantastic folktales, humans have been telling stories about animals—animals who can talk, feel, think, and make moral judgments just as we do—for a very long time. In contrast, scientific studies of the mental lives of animals have professed to be investigating the nature of animal minds slowly, cautiously, objectively, with no room for fanciful tales, fables, or myths. But recently, these folkloric and scientific traditions have merged in an unexpected and shocking way: scientists have attempted to prove that at least some animal fables are actually true. These interdisciplinary chapters examine how science has targeted the well-known Aesop's fable "The Crow and the Pitcher" as their starting point. They explore the ever-growing set of experimental studies which purport to prove that crows possess an understanding of higher-order concepts like weight, mass, and even Archimedes' insight about the physics of water displacement. The Aesop's Fable Paradigm explores how these scientific studies are doomed to accomplish little more than to mirror anthropomorphic representations of animals in human folklore and reveal that the problem of folkloric projection extends far beyond the "Aesop's Fable Paradigm" into every nook and cranny of research on animal cognition.

An unprecedented number of folklorists are addressing issues of class, race, gender, and sexuality in academic and public spaces in the US, raising the question: How can folklorists contribute to these contemporary political affairs? Since the nature of folkloristics transcends binaries, can it help others develop critical personal narratives? Advancing Folkloristics covers topics such as queer, feminist, and postcolonial scholarship in folkloristics. Contributors investigate how to apply folkloristic approaches in nonfolklore classrooms, how to maintain a folklorist identity without a "folklorist" job title, and how to use folkloristic knowledge to interact with others outside of the discipline. The chapters, which range from theoretical reorientations to personal experiences of folklore work, all demonstrate the kinds of work folklorists are well-suited to and promote the areas in which folkloristics is poised to expand and excel. Advancing Folkloristics presents a clear picture of folklore studies today and articulates how it must adapt in the future.

An unprecedented number of folklorists are addressing issues of class, race, gender, and sexuality in academic and public spaces in the US, raising the question: How can folklorists contribute to these contemporary political affairs? Since the nature of folkloristics transcends binaries, can it help others develop critical personal narratives? Advancing Folkloristics covers topics such as queer, feminist, and postcolonial scholarship in folkloristics. Contributors investigate how to apply folkloristic approaches in nonfolklore classrooms, how to maintain a folklorist identity without a "folklorist" job title, and how to use folkloristic knowledge to interact with others outside of the discipline. The chapters, which range from theoretical reorientations to personal experiences of folklore work, all demonstrate the kinds of work folklorists are well-suited to and promote the areas in which folkloristics is poised to expand and excel. Advancing Folkloristics presents a clear picture of folklore studies today and articulates how it must adapt in the future.