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The comparative approach to immunology can be traced to the era of
Pasteur and Metchnikov in which observations regarding foreign
recognition in invertebrates was a factor in the develop ment of
the principal concepts that created the foundation of what now is
the broad field of immunology. With each major experimental and
conceptual breakthrough, the classical, albeit essential, question
has been asked "are the immune systems of phylogenetically
primitive vertebrates and invertebrates similar to that of
mammals?" Somewhat surprisingly for the jawed verte brates, the
general answer has been a qualified form of "yes", whereas for
agnathans and invertebrate phyla it has been "no" so far. The
apparent abruptness in the appearance of the immune system of
vertebrates is linked to the introduction of the somatic generation
of the diversity of its antigen specific receptors. Therefore the
questions regarding the origin and evolution of the specific immune
system revolve around this phenomenon. With respect to the origin
of the system (aside from the or igin of the rearranging machinery
itself, the study of which is still in its infancy) one can ask
questions about the cellular and mo lecular contexts in which the
mechanism was introduced.
Never has so much progress been reported in immunology as at this
congress. The full impact of new technologies, developed since the
late 1970s, has come to fruition: gene isolation, mutation,
transfection and expression, protein structure and peptide
synthesis, cell cloning, hybridization and monoclonal antibodies,
CD serology, SCID and transgenic mice, modern immunomudulation and
vaccines. An overwhelming mass of data has accumulated over the
last years. The reports are up-to-date and outstanding, to a degree
no journal will ever achieve, and the results are presented in a
concise and lucid way. This report will serve as a guideline for
generations of immunologists to come. Hundreds of new alleys have
been opened, an abundance of research tools and goals are pointed
to. This volume is a treasure trove of explorations ahead of our
time - it is exciting reading. This progress report presents
outstanding contributions, worth many prizes - a feature which is
unusual for proceedings volumes. Immunology is exhibited at its
best: an exciting research area and a rewarding subject to study
for the benefit of mankind - today more than ever!
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