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The clinical laboratory plays a critical role in the diagnosis and
management of endocrine and related metabolic disorders, which are
leading causes of morbidity and mortality in children and adults.
The Handbook of Diagnostic Endocrinology, Third Edition, provides a
ready reference for the evaluation, diagnosis, and monitoring of
such disorders. This revision incorporates translational medicine,
connecting what clinicians need to know with those in research
providing a clinical context to which they can relate their
molecular findings. This book solves the needs of clinicians and
researchers by bringing together in one book endocrinology at the
molecular and clinical levels. As the intricacies of intracellular
signaling have become better understood, states of hormone
resistance are now increasingly recognized. The most common
endocrinopathy in westernized countries, the metabolic syndrome,
results, to a large extent, from insulin resistance. The complexity
of the circulating forms of various hormones are acknowledged in
this revision.
Beginning with an introduction that examines the portrayal of Lancelot and Guinevere from their origins to the present day, the sixteen essays in this collection deal with varied topics including feminist readings of the characters' representations and the depiction of the lovers in medieval manuscript illuminations, in film, and in other visual arts.
Success is envisioned as beating the competition to generate a
financially strong and profitable organization while building
stakeholder satisfaction. "C" Leadership style is a new management
theory derived from the research and science leading to the
unification of conflicting traditional leadership models.
Presenting a unique approach to address the needs of all
stakeholders as they contribute to the success of the organization,
"C" Leadership unifies task-centered styles with people-centered
styles for managing talent. Authors Jim and Lori Spina bring a
track record of success and achievement in the fields of Education,
Consulting and Business. Their "C" Leadership: A New Way to Beat
the Competition and Manage Organization Stakeholders introduces
this revolutionary and unique leadership style management system,
offering a strategy geared to beat the competition by addressing
the needs of all stakeholders who contribute to the success of the
organization.
Cultivating Empire charts the connections between missionary work,
capitalism, and Native politics to understand the making of the
American empire in the late-eighteenth and early-nineteenth
centuries. It presents American empire-building as a negotiated
phenomenon that was built upon the foundations of earlier Atlantic
empires, and it shows how U.S. territorial and economic development
went hand-in-hand. Lori. J. Daggar explores how Native authority
and diplomatic protocols encouraged the fledgling U.S. federal
government to partner with missionaries in the realm of Indian
affairs, and she charts how that partnership borrowed and deviated
from earlier imperial-missionary partnerships. Employing the
terminology of speculative philanthropy to underscore the ways in
which a desire to do good often coexisted with a desire to make
profit, Cultivating Empire links eighteenth- and
early-nineteenth-century U.S. Indian policy-often framed as
benevolent by its crafters-with the emergence of racial capitalism
in the United States. In the process, Daggar argues that Native
peoples wielded ideas of philanthropy and civilization for their
own purposes and that Indian Country played a critical role in the
construction of the U.S. imperial state and its economy. Rather
than understand civilizing missions simply as tools for
assimilation, then, Cultivating Empire reveals that missions were
hinges for U.S. economic and political development that could both
devastate Indigenous communities and offer Native peoples
additional means to negotiate for power and endure.
Over the last 50 years, drug development and clinical trials have
resulted in successful complete responses in diseases such as
childhood leukemia, testicular cancer and Hodgkin's disease. We are
still, however, confronted with over 500,000 cancer-related deaths
per year. Clearly, the phenomenon of drug resistance is largely
responsible for these failures and continues to be an area of
active investigation. Since the last volume in this series, we have
learned that the energy-dependent drug efflux protein,
p-glycoprotein, encoded by the MDR 1 gene, is a member of a family
of structurally related transport polypeptides, thus allowing us to
explore the relationship between structure and function. In
addition to ongoing well designed clinical trials aimed at
reversing MDR mediated drug resistance, the first gene therapy
studies with the MDR 1 gene retrovirally transduced into human bone
marrow cells are about to be initiated. Although MDR is currently
the most understood mechanism of drug resistance, we are uncovering
increasing knowledge of alternative molecular and biochemical
mechanisms of drug resistance to antimetabolites, cisplatin and
alkylating agents and developing new strategies for circumventing
such resistance. It is clear that drug resistance is complex, and
many mechanisms exist by which cancer cells may overcome the
cytotoxicity of our known chemotherapeutic agents. As our
understanding of each of these mechanisms expands, well designed
models will be necessary to test laboratory hypotheses and
determine their relationship to drug resistance in humans. It is
this integration of basic science and clinical investigation that
will both advance our scientific knowledge and result in the
improvement of cancer therapy.
Over the last 50 years, drug development and clinical trials have
resulted in successful complete responses in diseases such as
childhood leukemia, testicular cancer and Hodgkin's disease. We are
still, however, confronted with over 500,000 cancer-related deaths
per year. Clearly, the phenomenon of drug resistance is largely
responsible for these failures and continues to be an area of
active investigation. Since the last volume in this series, we have
learned that the energy-dependent drug efflux protein,
p-glycoprotein, encoded by the MDR 1 gene, is a member of a family
of structurally related transport polypeptides, thus allowing us to
explore the relationship between structure and function. In
addition to ongoing well designed clinical trials aimed at
reversing MDR mediated drug resistance, the first gene therapy
studies with the MDR 1 gene retrovirally transduced into human bone
marrow cells are about to be initiated. Although MDR is currently
the most understood mechanism of drug resistance, we are uncovering
increasing knowledge of alternative molecular and biochemical
mechanisms of drug resistance to antimetabolites, cisplatin and
alkylating agents and developing new strategies for circumventing
such resistance. It is clear that drug resistance is complex, and
many mechanisms exist by which cancer cells may overcome the
cytotoxicity of our known chemotherapeutic agents. As our
understanding of each of these mechanisms expands, well designed
models will be necessary to test laboratory hypotheses and
determine their relationship to drug resistance in humans. It is
this integration of basic science and clinical investigation that
will both advance our scientific knowledge and result in the
improvement of cancer therapy.
This book will take an in-depth look at the technologies,
processes, and capabilities to develop and produce "next
generation" energetic materials for both commercial and defense
applications, including military, mining operations, oil production
and well perforation, and construction demolition. It will serve to
highlight the critical technologies, latest developments, and the
current capability gaps that serve as barriers to military fielding
or transition to the commercial marketplace. It will also explain
how the processing technologies can be spun out for use in other
non-energetics related industries.
Developing talent is at the heart of any successful business, but
in an age of changing technology and social needs, how can you best
adapt to a new world and develop the talent your company needs?
Harnessing Change to Develop Talent and Beat the Competition
explores how organizations can formulate effective corporate level
and business level strategies to achieve competitive advantage,
earn above average profits, build and retain talent, and sustain
financial strength. Fitting into the gaps left by existing books,
expert authors James and Lori Spina explore the ideas and actions
business can take to meet local needs. For executives making
strategic business decisions, and for practitioners and researchers
across the business industry, this exciting new guide helps people
striving to obtain new levels of responsibility within an
organization, reinvigorate existing processes, and implementing a
new strategic management system.
A queen who helped define the cultural landscape of her era. As
duchess of Brittany [1491-1514] and twice queen of France [1491-98;
1498-1514], Anne de Bretagne set a benchmark by which to measure
the status of female authority in Europe at the dawn of the
Renaissance. Although at times a traditional political pawn, when
men who ruled her life were involved in reshaping European
alliances, Anne was directly or indirectly involved with the
principal political and religious European leaders of her time and
helped define the cultural landscape of her era. Taking a variety
of cross-disciplinary perspectives, these ten essays by art
historians, literary specialists, historians, and political
scientists contribute to the ongoing discussion ofAnne de Bretagne
and seek to prompt further investigations into her cultural and
political impact. At the same time, they offer insight of a broader
nature into related areas of intellectual interest - patronage, the
history of the book, the power and definition of queenship and the
interpretation of politico-cultural documents and court spectacles
- thereby confirming the extensive nature of Anne's legacy. CYNTHIA
J. BROWN is Professor of French at the University of California,
Santa Barbara.
HR departments endeavour to occupy strategic roles in
organizations, a goal that is seldom or ever realized. James and
Lori Spina bring their academic and corporate backgrounds together
to analyse and direct on how strategic human resources cohesively
contribute towards gaining competitive advantage, above average
profits, building and retaining talent, sustaining financial
strength, and addressing challenges of stakeholder satisfaction.
Stepping beyond unclear discussions about strategy that fail to
satisfy the needs of all departments, The New HR instead
illustrates how human resource leaders can constructively create
and nurture teams that think strategically and produce harmony
between HR activities and the wider organization. The New HR is
essential reading for human resources executives who desire to make
strategic business decisions that ensure the sustainability and
growth of the organization and, at the same time, look for new ways
to develop the business, strategic, and critical thinking skills of
current employees.
Essays demonstrating that Arthur belonged to the whole of Europe -
not just England. The European dimensions of Arthurian literature
form the focus of this special issue of Arthurian Literature,
derived from sessions held at the International Conference in
Utrecht (2005). It brings out in particular the supranational
coherence of the Arthurian genre, and the ways in which its motifs
appear throughout European literature. Questions discussed here
include the function of Perceval in a variety of Arthurian
romances, the character of Gauvain in the French, Dutch and English
traditions, the narrator in different versions of the Prose
Lancelot, and the concept of 'youth' in Scandinavian and Old French
romances. BART BESAMUSCA and FRANK BRANDSMA lecture at Utrecht
University. Contributors: BART BESAMUSCA, FRANK BRANDSMA, CORA
DIETL, SARAH GORDON, LINDA GOWANS, MARJOLEIN HOGENBIRK, SUSANNE
KRAMARZ-BEIN, NORRIS J. LACY, MARTINE MEUWESE, STEFANO MULA, JOSEPH
M. SULLIVAN,LORI J. WALTERS.
We hear a lot about the necessity of meeting needs of changing
markets by developing people, but we hear less about ways implement
change. How can we design effective ways to implement change and
maintain and build job satisfaction? James and Lori Spina
illustrate how a strategic system aligns workplace transitions with
the organizational vision, mission, and top level strategies to
meet the needs of all stakeholders, ensure a steady flow of talent
from within, and anticipate abilities and skills for jobs not yet
created. They provide a road map for how to carry this out and
propose a cutting-edge leadership style to complement this
strategic approach and beat the competition. They demonstrate in
detail on how to meet the emerging learning needs of high potential
people who are striving to obtain new levels of responsibility.
This book is crucial reading for executives who make strategic
business decisions to ensure the sustainability and growth of their
organizations.
New editor, new directions: the series broadens its scope to
encompass European literatures other than French and English;
still, however, "an indispensable component of any historical or
Arthurian library". NOTES AND QUERIES This new volume of Arthurian
Literature, the first under its new editor Keith Busby, is devoted
to the Roman van Walewein(The Romance of Walewein [Gawain]) by
Penninc and Pieter Vostaert, an undisputed gem of Middle Dutch
literature which has recently become accessible to an
English-speaking audience through translation. Essentially a
fairy-tale written into Arthurian romance, it presents a Gawain
quite different to the man found in the English Sir Gawain and the
Green Knightor the French Gauvain. Expert readings of the Walewein,
especially commissioned and collected by BART BESAMUSCA and ERIK
KOOPERof the University of Utrecht are provided by a group of
renowned scholars, contributing to the on-going critical appraisal
of the Walewein. KEITH BUSBY is George Lynn Cross Research
Professor at the Center for Medieval and Renaissane Studies,
University of Oklahoma. Contributors: BART BESAMUSCA, ERIK KOOPER,
WALTER HAUG, DOUGLAS KELLY, NORRIS J. LACY, MATHIAS MEYER, AD
PUTTER, FELICITY RIDDY, THEA SUMMERFIELD, JANE H.M. TAYLOR, BART
VELDHOEN, NORBERT VOORWINDEN, LORI WALTERS
* Invites the reader behind the scenes of Bible stories * Opens new
perspectives for individuals, study groups, and sermon writers What
was the reaction of the head waiter at the wedding at Cana when he
realized the wine had run out? What gave the man the idea to lower
his paralyzed friend through the roof to see Jesus? What were the
young men who accompanied Abraham and Isaac on the journey to the
mountain thinking? Much of scripture is comprised of individuals
who are unnamed but have important roles to play in biblical
stories. This illustrated book offers first person accounts of
twenty-one Bible stories (Old Testament, New Testament, and
apocrypha) from the perspectives of bystanders or "sup-porting"
characters, giving us an opportunity to imagine: how would we
react? What would we say or do given similar circumstances today?
This imaginative collection includes thought-provoking discussion
questions for congregational or individual reflection, and can be
invaluable for fresh perspectives in sermons and study groups.
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