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Anticancer Drug Resistance - Advances in Molecular and Clinical Research (Paperback, Softcover reprint of the original 1st ed. 1994)
Loot Price: R5,433
Discovery Miles 54 330
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Anticancer Drug Resistance - Advances in Molecular and Clinical Research (Paperback, Softcover reprint of the original 1st ed. 1994)
Series: Cancer Treatment and Research, 73
Expected to ship within 10 - 15 working days
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Over the last 50 years, drug development and clinical trials have
resulted in successful complete responses in diseases such as
childhood leukemia, testicular cancer and Hodgkin's disease. We are
still, however, confronted with over 500,000 cancer-related deaths
per year. Clearly, the phenomenon of drug resistance is largely
responsible for these failures and continues to be an area of
active investigation. Since the last volume in this series, we have
learned that the energy-dependent drug efflux protein,
p-glycoprotein, encoded by the MDR 1 gene, is a member of a family
of structurally related transport polypeptides, thus allowing us to
explore the relationship between structure and function. In
addition to ongoing well designed clinical trials aimed at
reversing MDR mediated drug resistance, the first gene therapy
studies with the MDR 1 gene retrovirally transduced into human bone
marrow cells are about to be initiated. Although MDR is currently
the most understood mechanism of drug resistance, we are uncovering
increasing knowledge of alternative molecular and biochemical
mechanisms of drug resistance to antimetabolites, cisplatin and
alkylating agents and developing new strategies for circumventing
such resistance. It is clear that drug resistance is complex, and
many mechanisms exist by which cancer cells may overcome the
cytotoxicity of our known chemotherapeutic agents. As our
understanding of each of these mechanisms expands, well designed
models will be necessary to test laboratory hypotheses and
determine their relationship to drug resistance in humans. It is
this integration of basic science and clinical investigation that
will both advance our scientific knowledge and result in the
improvement of cancer therapy.
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