Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

A little boy is lost at the festival--can PC Seth and PC Thea help? It's all in a day's work for a busy police officer in this entertaining story about the responsibilities of being in the police force. Next Steps are included at the back of the book to prompt further discussion and develop vocabulary. More information is provided about the Busy People and the type of equipment they need as well as the characters that work alongside them, for example, an engineer that designs shuttles or police dog handlers.

What's it like being a firefighter? Let's find out! Step inside the life of Frank the firefighter and discover the challenges he faces in his very busy job. Follow him and his crew from the moment the fire station alarm bell rings to his arrival at the emergency and learn about the inspirational life of a firefighter. An entertaining story following a day in the life of a firefighterfor children aged 4+, with fun illustrations to engage and inspire young readers. Turn to the back of the book for more information about what a firefighter's job involves, the equipment they need and the other busy people that work alongside them. The Next Steps include discussion points about the story to prompt further conversation, develop vocabulary and support comprehension. People who help us, people who care, busy people are everywhere! Encourage the next generation of busy people and learn about a range of careers in this inspiring series for young children. Each story focuses on a different professional as they go about their daily work, exploring what each job involves, why it's important and how it can be rewarding. If you enjoyed this book, check out the other titles in the Busy People series: Busy People: Astronaut Busy People: Builder Busy People: Construction Worker Busy People: Doctor Busy People: Firefighter Busy People: Librarian Busy People: Police officer Busy People: Teacher Busy People: Vet

In their homelands in what is now New York State, Iroquois and their issues have come to dominate public debate as the residents of the region seek ways to resolve the multibillion dollar land claims against the state. This initial dispute over territorial title has grown to encompass gambling, treaties, taxation, and what it means to claim Native sovereignty in a world experiencing fantastic technological change. New York's influence is such that the experiences of Iroquois interaction with the state will surely affect how Natives and other states deal with similar issues. This is an essential volume for those wishing to better understand these issues, written from an Iroquois perspective by someone who has taken an active role in tribal affairs and who is dedicated to preserving the philosophies of his people. Douglas George-Kanentiio, a member of the Mohawk Nation and an activist for Native American claims, details the history of his Nation from initial contact with the Europeans through to the casino crises. As a key figure in events of the last two decades, George-Kanentiio uses aspects of his personal story to highlight issues of public interest: the land, family and community, geography, federal interference in tribal affairs, religion, political activism, land use/claims, and connections to organized crime.

This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer's disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders

Today, any regular newspaper reader is likely to be exposed to reports on manifold forms of (physical, emotional, sexual) child abuse on the one hand, and abnormal behavior, misconduct or offences of children and minors on the other hand. Occasionally reports on children as victims and children as offenders may appear on the same issue or even the same page. Rather seldom the more complex and largely hidden phenomena of structural hostility or indifference of society with a view to children are being dealt with in the press. Such fragmentary, ambiguous, incoherent or even contradictory perception of children in modem society indicates that, firstly, there is a lack of reliable information on modem childhood, and secondly, children are still treated as a comparatively irrelevant population group in society. This conclusion may be surprising in particular when drawn at the end of The Century of the Child proclaimed by Ellen Key as early as 1902. Actually, there exist unclarities and ambiguities about the evolution of childhood in the last century not only in public opinion, but also in scientific literature. While De Mause with his psycho-historic model of the evolution of childhood, comprising different stages from infanticide, abandonment, ambivalence, intrusion, socialisation to support, underlines the continuous improvement of the condition of childhood throughout history and thus rather confirms Key's expectations, Aries, with his social history of childhood, seems to hold a more culturally pessimistic view.

Religious Representation in Place brings together an interdisciplinary group of scholars from the Humanities and Sciences to broaden the understanding of how religious symbols and spatial studies interact. The essays consider the relevance of religion in the experience of space, a fundamental dimension of culture and human life.

The variety and the international focus of the cases, be they environmental, health or management successes or failures, makes this book more appealing to a wider audience. These cases examine sociocultural issues associated with responding to a variety of crises. Additionally, a unique feature of the book is a section titled Views from the Expert, which appears at the end of each chapter. Because the expert in question is not connected in any way to the crisis, she or he share disinterested opinions and insights on the specifics of a crisis that confronted an organization. To expand the boundaries of the knowledge and the practice of communication for crisis management to one that addresses the effects of the confluence of globalization and technology on business paradigms and on practitioner competencies.The international nature and the variety of the cases, both on profit and nonprofit organizations and government agencies, and the crisis expert 's views at the end of each chapter, coupled with discussion questions, makes the textbook appealing to an international audience. The implications of the globalization process for crisis management is also be addressed.

Neuromarketing in Action provides an in-depth review of how the brain functions and the ways in which it unconsciously influences consumer behaviour. It shows both the scientific frameworks and the practical applications of this increasingly popular marketing tool. Referencing many global brands such as Aston Martin, Hermes, Virgin, Facebook, Ralph Lauren and Fuji, the authors, whose background covers both neuroscience and marketing, showcase the latest thinking on brain function and intelligence, and on the subconscious influences on consumer behaviour. Neuromarketing in Action then examines the ways in which marketing efficiency can be improved through the satisfaction of the customer's senses, emotions, memory and conscience and looks at the impact on current marketing activities such as selling methods, sensory marketing and product modification, and on future strategies like value innovation, sensory brands, increased interaction with social networks and permission marketing.

This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer's disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders

Religious Representation in Place brings together an interdisciplinary group of scholars from the Humanities and Sciences to broaden the understanding of how religious symbols and spatial studies interact. The essays consider the relevance of religion in the experience of space, a fundamental dimension of culture and human life.

An insight into new advances of current interest in metal toxicology, such as mechanisms important in risk-assessment for human health. The book also has chapters on emerging conceptual problems including resistance to metal toxicity effects on gene expression, alongside principles regarding drug-chelation of metals, the potential use of prophyrins as indicators of metal exposure and toxicity. The toxicology of specific metals of major public health concern are discussed in depth, such as mercury, aluminum, arsenic, chromium, and cadmium. Of interest to basic scientists as well as public health administrators.