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Over the past two decades bioscience facilities worldwide have
experienced multiple safety and security incidents, including many
notable incidents at so-called "sophisticated facilities" in North
America and Western Europe. This demonstrates that a system based
solely on biosafety levels and security regulations may not be
sufficient. Setting the stage for a substantively different
approach for managing the risks of working with biological agents
in laboratories, Laboratory Biorisk Management: Biosafety and
Biosecurity introduces the concept of biorisk management-a new
paradigm that encompasses both laboratory biosafety and
biosecurity. The book also provides laboratory managers and
directors with the information and technical tools needed for its
implementation. The basis for this new paradigm is a three-pronged,
multi-disciplinary model of assessment, mitigation, and performance
(the AMP model). The application of the methodologies, criteria,
and guidance outlined in the book helps to reduce the risk of
laboratories becoming the sources of infectious disease outbreaks.
This is a valuable resource for those seeking to embrace and
implement biorisk management systems in their facilities and
operations, including the biological research, clinical diagnostic,
and production/manufacturing communities.
By achieving a delicate balance between systems and practices,
proper laboratory biosecurity reduces the risk of legitimate
bioscience facilities becoming sources of pathogens and toxins for
malicious use. Effective design and implementation of laboratory
biosecurity depends on cooperation among individuals from diverse
communities, including scientists, technicians, policy makers,
security engineers, and law enforcement officials. Providing
guidance to the broad international community, Laboratory
Biosecurity Handbook addresses the objectives of biosecurity and
the ways in which they overlap or conflict with those of biosafety.
The book describes the risks of working with dangerous pathogens
and toxins in the current era of international terrorism. The
authors characterize the global spread of legitimate biotechnology
and relate it to the rise of transnational terrorism, emphasizing
the need for biosecurity measures even in legitimate bioscience.
The book discusses biosecurity risk assessment-a practical
methodology that allows laboratory management and
biosafety/biosecurity officers to analyze and determine the level
of risk, and serves as a basis for managing those risks. The book
includes questionnaires that can assist the process of collecting
data for a biosecurity vulnerability assessment, example standard
operating procedures and memoranda of understanding, and other
useful reference material. Addressing a variety of operating
environments and the particular challenges they face when designing
and implementing laboratory biosecurity, this book can assist
bioscience facilities ranging from the large to the small, from
those that focus on diagnosis or vaccine development, to those only
minimally involved with infectious diseases. The detailed
recommendations help avoid a "one-size-fits-all" approach to
security and save limited resources. The book shows institutions
how to develop and implement a biosecurity plan, and helps ensure
that all components are included in the overall system, whether
existing or new.
Over the past two decades bioscience facilities worldwide have
experienced multiple safety and security incidents, including many
notable incidents at so-called "sophisticated facilities" in North
America and Western Europe. This demonstrates that a system based
solely on biosafety levels and security regulations may not be
sufficient. Setting the stage for a substantively different
approach for managing the risks of working with biological agents
in laboratories, Laboratory Biorisk Management: Biosafety and
Biosecurity introduces the concept of biorisk management-a new
paradigm that encompasses both laboratory biosafety and
biosecurity. The book also provides laboratory managers and
directors with the information and technical tools needed for its
implementation. The basis for this new paradigm is a three-pronged,
multi-disciplinary model of assessment, mitigation, and performance
(the AMP model). The application of the methodologies, criteria,
and guidance outlined in the book helps to reduce the risk of
laboratories becoming the sources of infectious disease outbreaks.
This is a valuable resource for those seeking to embrace and
implement biorisk management systems in their facilities and
operations, including the biological research, clinical diagnostic,
and production/manufacturing communities.
This book provides up-to-date information on globalisation trends
and the transformations taking place in emerging markets. It
discusses key themes of relevance to the auto industry, including
the environmental impact of the car, adaptation of designs for the
needs of emerging markets and the emergence of global
mega-suppliers. These issues are placed in the context of more
general debates about globalisation and current crises in emerging
markets such as Brazil and East Asia.
This book provides up-to-date information on globalisation trends
and the transformations taking place in emerging markets. It
discusses key themes of relevance to the auto industry, including
the environmental impact of the car, adaptation of designs for the
needs of emerging markets and the emergence of global
mega-suppliers. These issues are placed in the context of more
general debates about globalisation and current crises in emerging
markets such as Brazil and East Asia.
Most international historians present the outbreak of World War II
as the result of an irreconcilable conflict between Great Britain
and Germany. This ubiquitous Anglo-German perspective fails to
recognize complex causes and repercussions of international events,
misappropriates historical responsibilities, and overlooks many
global and imperial factors of the war's origins. Reynolds M.
Salerno shows that the situation in the Mediterranean played a
decisive role in the European drama of the late 1930s and
profoundly influenced the manner in which the Second World War
unfolded. Vital Crossroads is the result of the author's remarkable
access to and extensive research in twenty-eight archives in five
different countries. Concentrating on the period from the
Mediterranean crisis of 1935 to Italy's declaration of war in June
1940, Salerno demonstrates that the international politics of
pre-World War II Europe particularly in the Mediterranean can only
be understood as the multilateral interaction of British, French,
German, and Italian foreign and defense policies. Control of the
Mediterranean, he asserts, was a central concern for the European
powers in 1935 40, and a fundamental reason why Europe went to war
and why the conflict unfolded as it did. As a result, France and
Italy influenced and often determined the nature and direction of
Allied and Axis policy to an extent disproportionate to their
nations' military and economic strength.Salerno contends that the
Allies' reluctance to take decisive action against Fascist Italy in
1939 40 contributed to the fall of France in 1940, Britain's
desperate situation in 1940 41, and the post-war collapse of
Britain as a world power. At a time when the Allied powers dreaded
the ability of the German military to march across the European
continent, they also feared that the Italian armed forces would
strive to fulfill Mussolini's grand imperial ambitions in the
Mediterranean."
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