This book presents the latest findings in mechanosensitive ion channel research compiled by a number of internationally recognized experts in the field of mechanosensitivity, specializing in mechanosensitive or mechanically gated ion channels and the underlying mechanosensitive signaling cascades. The book provides a comprehensive description of mechanotransduction, which is defined as the biochemical response of cells to mechanical stimulation, and provides the reader with the latest vision of signaling cascades. Descriptions of the most widely used experimental models, the methods of choice and references to experimental protocols, the latest experimental findings and current vision, and potential problems in data interpretation, will be of considerable use to all those interested in this field of research.

This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.