This book deals find out the pharmacokinetic profiles data and design the dosage regimen of cinchona officinalis for measuring safety and efficacy from conventional dosage form. The rationale of this project work was to formulate oral conventional herbal tablets containing Quinine in herbal extract and to determine the pharmacokinetic profile of the same (formulated herbal extract tablets). The pharmacokinetic profile of the herbal formulation was compared with the pharmacokinetic profile of the pure quinine formulation and marketed formulation. Since herbal formulations consist of natural plant material and not a synthesized chemical, herbal remedies are less likely to cause unpleasant side effects than conventional pharmaceutical drugs. Thus, herbal remedies are precised safer, gentler and lower costing than conventional drugs.

This book deals with the Pharmacokinetic evaluation of Sitagliptin, which is an oral DPP-4 inhibitor for the treatment of Type 2 Diabetes. This book provides the information about bio-analytical method development and validation of drugs by high performance liquid chromatography. The developed method for Sitagliptin in this book might be applicable to bioavailability and bioequivalence studies. Users of this book will be provided the simple, sensitive and validated bio-analytical method for the estimation of Sitagliptin in plasma and its applications to the pharmacokinetic studies.