|
Showing 1 - 25 of
28 matches in All Departments
This book provides a detailed account of the most recent
developments, challenges and solutions to seamlessly advance and
launch a lyophilized biologics or vaccine product, based on diverse
modalities, ranging from antibodies (e.g., monoclonal, fused),
complex biologics (e.g., antibody drug conjugate, PEGylated
proteins), and vaccines (e.g., recombinant-protein based). The
authors adeptly guide the reader through all crucial aspects, from
biophysical and chemical stability considerations of proteins,
analytical methods, advances in controlled ice nucleation and
quality-by-design approaches, alternate drying technology, to
latest regulatory, packaging and technology transfer considerations
to develop a stable, safe and effective therapeutic protein,
vaccine and biotechnology products. Lyophilized Biologics and
Vaccines: Modality-Based Approaches is composed of four sections
with a total of 17 chapters. It serves as a reference to all
critical assessments and steps from early pre-formulation stages to
product launch: Provides recent understanding of heterogeneity of
protein environment and selection of appropriate buffer for
stabilization of lyophilized formulations Details the latest
developments in instrumental analysis and controlled ice nucleation
technology Explains in-depth lyophilized (or dehydrated)
formulation strategies considering diverse modalities of biologics
and vaccines, including plasmid DNA and lipid-based therapeutics
Details an exhaustive update on quality-by-design and process
analytical technology approaches, illustrated superbly by case
studies and FDA perspective Provides the latest detailed account of
alternate drying technologies including spray drying, bulk
freeze-drying and crystallization, supported exceptionally by case
studies Provides a step-by-step guide through critical
considerations during process scale-up, technology transfer,
packaging and drug delivery device selection, for a successful
lyophilization process validation, regulatory submission and
product launch Chapters are written by one or more world-renowned
leading authorities from academia, industry or regulatory agencies,
whose expertise cover lyophilization of the diverse modalities of
biopharmaceuticals. Their contributions are based on the exhaustive
review of literature coupled with excellent hands-on experiences in
laboratory or GMP setup, making this an exceptional guide to all
stages of lyophilized or dehydrated product development.
Development of new-generation vaccines is now more challenging than
ever, as identifying, purifying and evaluating vaccine antigens is
a complex undertaking. Most importantly, once the relevant antigens
have been identified, key focus then shifts to the development of
suitable delivery systems and formulations to achieve maximum in
vivo potency with minimum potential side effects. These novel
formulations-many of which will be nanoparticulates-can deliver the
antigens to the desired site, to the relevant antigen presenting
cells, and prevent systemic exposure of the immune potentiators.
The proposed book will outline all the critical steps that need to
be considered for successful development of various types of
nanoparticulate delivery systems for vaccine antigens. These
contributions from leading experts in the area of vaccine
formulation and delivery systems will tie in what is the most
current status, including clinical evaluations with these novel
vaccine technologies.
This book highlights the proceedings of the International
Conference on Atomic, Molecular, Optical and Nano-Physics with
Applications (CAMNP 2019), organized by the Department of Applied
Physics, Delhi Technological University, New Delhi, India. It
presents experimental and theoretical studies of atoms, ions,
molecules and nanostructures both at the fundamental level and on
the application side using advanced technology. It highlights how
modern tools of high-field and ultra-fast physics are no longer
merely used to observe nature but can be used to reshape and
redirect atoms, molecules, particles or radiation. It brings
together leading researchers and professionals on the field to
present and discuss the latest finding in the following areas, but
not limited to: Atomic and Molecular Structure, Collision
Processes, Data Production and Applications Spectroscopy of Solar
and Stellar Plasma Intense Field, Short Pulse Laser and Atto-Second
Physics Laser Technology, Quantum Optics and applications Bose
Einstein condensation Nanomaterials and Nanoscience
Nanobiotechnolgy and Nanophotonics Nano and Micro-Electronics
Computational Condensed Matter Physics
Proceedings of an International Conference on Current Developments
in Atomic, Molecular, and Chemical Physics with Applications, held
March 20-22, 2002, in Delhi, India.
The 38 chapters cover a broad range of research activities
categorized into four sub-topics, namely:
* Processes in Laser Fields,
* Chemical Physics,
* Collision Processes,
* Atomic Structure and Applications.
This book presents contributions of mathematicians covering topics
from ancient India, placing them in the broader context of the
history of mathematics. Although the translations of some Sanskrit
mathematical texts are available in the literature, Indian
contributions are rarely presented in major Western historical
works. Yet some of the well-known and universally-accepted
discoveries from India, including the concept of zero and the
decimal representation of numbers, have made lasting contributions
to the foundation of modern mathematics. Through a systematic
approach, this book examines these ancient mathematical ideas that
were spread throughout India, China, the Islamic world, and Western
Europe.
This book provides a detailed account of the most recent
developments, challenges and solutions to seamlessly advance and
launch a lyophilized biologics or vaccine product, based on diverse
modalities, ranging from antibodies (e.g., monoclonal, fused),
complex biologics (e.g., antibody drug conjugate, PEGylated
proteins), and vaccines (e.g., recombinant-protein based). The
authors adeptly guide the reader through all crucial aspects, from
biophysical and chemical stability considerations of proteins,
analytical methods, advances in controlled ice nucleation and
quality-by-design approaches, alternate drying technology, to
latest regulatory, packaging and technology transfer considerations
to develop a stable, safe and effective therapeutic protein,
vaccine and biotechnology products. Lyophilized Biologics and
Vaccines: Modality-Based Approaches is composed of four sections
with a total of 17 chapters. It serves as a reference to all
critical assessments and steps from early pre-formulation stages to
product launch: Provides recent understanding of heterogeneity of
protein environment and selection of appropriate buffer for
stabilization of lyophilized formulations Details the latest
developments in instrumental analysis and controlled ice nucleation
technology Explains in-depth lyophilized (or dehydrated)
formulation strategies considering diverse modalities of biologics
and vaccines, including plasmid DNA and lipid-based therapeutics
Details an exhaustive update on quality-by-design and process
analytical technology approaches, illustrated superbly by case
studies and FDA perspective Provides the latest detailed account of
alternate drying technologies including spray drying, bulk
freeze-drying and crystallization, supported exceptionally by case
studies Provides a step-by-step guide through critical
considerations during process scale-up, technology transfer,
packaging and drug delivery device selection, for a successful
lyophilization process validation, regulatory submission and
product launch Chapters are written by one or more world-renowned
leading authorities from academia, industry or regulatory agencies,
whose expertise cover lyophilization of the diverse modalities of
biopharmaceuticals. Their contributions are based on the exhaustive
review of literature coupled with excellent hands-on experiences in
laboratory or GMP setup, making this an exceptional guide to all
stages of lyophilized or dehydrated product development.
The field of Atomic and Molecular Physics (AMP) has reached
significant advances in high-precision experimental measurement
techniques. The area covers a wide spectrum ranging from
conventional to new emerging multi-disciplinary areas like physics
of highly charged ions (HCI), molecular physics, optical science,
ultrafast laser technology etc. This book includes the important
topics of atomic structure, physics of atomic collision,
photoexcitation, photoionization processes, Laser cooling and
trapping, Bose Einstein condensation and advanced technology
applications of AMP in the fields of astronomy, astrophysics,
fusion, biology and nanotechnology. This book is useful for
researchers, professors, graduate, postgraduate and PhD students
dealing with atomic and molecular physics. The book has a wide
scope with applications in neighboring fields like plasma physics,
astrophysics, cold collisions, nanotechnology and future fusion
energy sources like ITER (international Thermonuclear Experimental
Reactor) Tokomak plasma machine, which need accurate AMP data.
Development of new-generation vaccines is now more challenging than
ever, as identifying, purifying and evaluating vaccine antigens is
a complex undertaking. Most importantly, once the relevant antigens
have been identified, key focus then shifts to the development of
suitable delivery systems and formulations to achieve maximum in
vivo potency with minimum potential side effects. These novel
formulations-many of which will be nanoparticulates-can deliver the
antigens to the desired site, to the relevant antigen presenting
cells, and prevent systemic exposure of the immune potentiators.
The proposed book will outline all the critical steps that need to
be considered for successful development of various types of
nanoparticulate delivery systems for vaccine antigens. These
contributions from leading experts in the area of vaccine
formulation and delivery systems will tie in what is the most
current status, including clinical evaluations with these novel
vaccine technologies.
Proceedings of an International Conference on Current Developments
in Atomic, Molecular, and Chemical Physics with Applications, held
March 20-22, 2002, in Delhi, India. The 38 chapters cover a broad
range of research activities categorized into four sub-topics,
namely: * Processes in Laser Fields, * Chemical Physics, *
Collision Processes, * Atomic Structure and Applications.
Novel Approaches and Strategies for Biologics, Vaccines and Cancer
Therapies takes a look at the current strategies, successes and
challenges involved with the development of novel formulations of
biologics, vaccines and cancer therapy. This thorough reference on
the latest trends in the development of diverse modalities will
appeal to a broad community of scientists, students and clinicians.
Written by leading authors across academia and industry, this book
covers important topics such as unique drug delivery devices,
non-parenteral delivery trends, novel approaches to the treatment
of cancer, immunotherapy and more. It includes real-world cases and
examples which highlight formulations with therapeutic proteins,
monoclonal antibodies, peptides and biobetters, as well as cases on
novel vaccines formulations including evolving pathogens, novel
modalities of vaccines, universal vaccines. This book is a thorough
and useful resource on the development of novel biologics, vaccines
and cancer therapies.
Mahatma Gandhi's humane philosophy and inherent spirituality had a
profound influence not only on the people of India but the freedom
loving people worldwide. 11th of September 2006 marked the
centenary of the Satyagraha movement launched by Mahatma Gandhi in
South Africa for peaceful resistance against discriminatory and
unjust laws. ""Satyagraha - the firmness of the force Truth""
became a powerful mass movement of peaceful resistance and civil
disobedience. Over the years, it evolved into a dynamic mass
movement of effective action.Commemorating 100 years of
'Satyagraha' in a befitting manner, the Indian National Congress
convened a two day international conference: ""Peace, Non-violence
and Empowerment: Gandhian Philosophy in the 21st Century"". Over
300 international delegates from 91 countries comprising world
leaders, Nobel laureates, leading peace and human rights activists
and Gandhian scholars reflected on the essence and the enduring
relevance of Mahatma Gandhi's philosophy. The conference
deliberated on subjects and issues which represent the core of
Gandhian thought. The discussion touched upon a wide range of
Gandhian principles and values including Mahatma Gandhi's concern
for the poor and his abiding commitment to non-violence and
people's empowerment. Emerging from the discussions amongst the
luminaries was the collective affirmation to renew people's
commitment to Mahatma's noble mission of building a world that is
in peace and harmony with itself.Based on the deliberations of this
conference, together with precious archival material, this volume -
a book for the future - endeavours to reach out and connect the
people, especially the younger generation, to the 'Gandhian way'
and to carry forward his legacy into the 21st century.
This set of five volumes documents the life and work of Manmohan
Singh, an academic, a policymaker, and a politician who has had a
deep impact on India and its economy. The volumes offer his
selected speeches, articles, and interviews, starting from the
1950s, when he was in the academia, through the 1980s and 1990s,
when he was India's finance minister, to 2004-14, when he was the
prime minister of India. Manmohan Singh's writings reflect on the
reforms that transformed the Indian economy and lay the foundations
for a stronger medium-term growth story than the kind that India
had witnessed in the preceding 44 years since Independence. The
five volumes bring together Singh's essays and speeches on various
subjects- economic reforms, India's export trends and the prospects
for self-sustained growth, trade and development, and international
economic order and equity in development.
An aerodynamic design procedure that uses neural networks to model
the functional behavior of the objective function in design space
has been developed. This method incorporates several improvements
to an earlier method that employed a strategy called
parameter-based partitioning of the design space in order to reduce
the computational costs associated with design optimization. As
with the earlier method, the current method uses a sequence of
response surfaces to traverse the design space in search of the
optimal solution. The new method yields significant reductions in
computational costs by using composite response surfaces with
better generalization capabilities and by exploiting synergies
between the optimization method and the simulation codes used to
generate the training data. These reductions in design optimization
costs are demonstrated for a turbine airfoil design study where a
generic shape is evolved into an optimal airfoil.
|
You may like...
Midnights
Taylor Swift
CD
R394
Discovery Miles 3 940
|