Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. "Ocular Toxicity in Laboratory Animals" provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes.

The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, "Ocular Toxicity in Laboratory Animals" is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies."

A powerful new addition to the bestselling Gothic Fantasy series of new writing and classic stories. Buried treasure, greed and envy are powerful forces in the minds of many, but at sea the consequences can be terrifying and deadly. With tales of pirates, deathly fogs and ferocious rocks, these dark tales of the haunted mind, trapped like ghosts at sea, are sure to entertain and enthrall. These new authors appear alongside the following classic and essential writers: Joseph Conrad, James Fenimore Cooper, Stephen Crane, F. Marion Crawford, Arthur Conan Doyle, William Hope Hodgson, Homer, W.W. Jacobs, Rudyard Kipling, Vernon Lee, H.P. Lovecraft, Richard Middleton, Edgar Allan Poe, Robert Louis Stevenson, H.G. Wells.

This volume brings together a group of essays that examine the relationship between philosophy and literature - disciplines that have been opposed as often as they have been combined. While the focus is primarily on the plays of Shakespeare, there is a lengthy essay on the use of the style term maniera in art history, and a concluding survey and analysis of the relationship between philosophy and literature, from Plato to the present. The author applies the theory of meaning and logical analysis to contemporary problems in the arts and aesthetics.

Children with low self-esteem will have difficulty in partaking in classroom lessons and succeeding. If we want to help children in the primary school to achieve the positive outcomes set out in the Every Child Matters agenda, we need to ensure all children have a healthy self-esteem. This book seeks to give adults in schools tools to look at the way they could enhance self esteem in children. The book comes with an accompanying CD-Rom which contains: - inset sessions for all adults in the school - workshops specifically aimed at non-teaching personnel, including mid-day supervisors - sessions for teachers and classroom assistants - classroom lessons and activity sheets for the children which can form part of your school's personal, social and health education (PSHE) programme. This book is a whole school training programme for raising self-esteem and is essential reading for all those working in primary education. Margaret Collins is a former headteacher of infant and first schools. She is now Senior Visiting Fellow in the School of Education at the University of Southampton. She researches children's perceptions of health education topics, writes teaching materials for children, books and articles on PSHE.

Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.

Critical acclaim for Sisters in the Resistance

"Often moving . . . always fascinating . . . women in the French Resistance is a key subject. Margaret Weitz has gathered personal testimonies . . . and set them in an intelligible context that helps us understand how all French people—men and women—experienced the Nazi occupation." —Robert Paxton, Mellon Professor of Social Sciences, Columbia University, and author of Vichy France: Old Guard and New Order, 1940-1944.

"Compulsive reading . . . a valuable book which vividly portrays the intricacies of resistance within France, written in an easy but serious style." —Times Literary Supplement (London).

"An absolutely stunning and compelling chronicle of dauntless courage and unflagging patriotism." —Booklist.

"[Margaret Collins Weitz's] well-researched, thoughtful study. . . has filled a gap in the history of World War II." —Publishers Weekly.

"Balancing absorbing narrative and astute analysis, Margaret Collins Weitz has integrated the unsung achievements of women into the history of the French Resistance." —Carole Fink, Professor of History, The Ohio State University, and author of Marc Bloch: A Life in History.

"Fifty years after the end of World War II, Sisters in the Resistance renders homage to the courageous women of the French Resistance. It is high time for their contributions to be fully acknowledged, and fortunate indeed that they have found such a sympathetic, scholarly, and lucid chronicler in Margaret Collins Weitz." —Marilyn Yalom, author of Blood Sisters: The French Revolution in Women's Memory.

Lucie Aubrac (1912-2007), of Catholic and peasant background, was teaching history in a Lyon girls' school and newly married to Raymond, a Jewish engineer, when World War II broke out and divided France. The couple, living in the Vichy zone, soon joined the Resistance movement in opposition to the Nazis and their collaborators. Outwitting the Gestapo is Lucie's harrowing account of her participation in the Resistance: of the months when, though pregnant, she planned and took part in raids to free comrades—including her husband, under Nazi death sentence—from the prisons of Klaus Barbie, the infamous Butcher of Lyon. Her book is also the basis for the 1997 French movie, Lucie Aubrac, which was released in the United States in 1999.   Purchase the audio edition.

Circle Time for the Very Young has been used by teachers and practitioners alike for the last ten years Now in its Third Edition, this book has been fully updated and includes a CD Rom to help you with Circle Time in your early years setting.

Circle Time is used to help form positive relationships, increase confidence and self-esteem and provide a safe environment to explore feelings and opinions.

Covering the 3 to 9 age range and focused on the core PSHE themes this book contains the following to help you establish, and maintain, circle time in your setting: an explanation of circle time and how it works, over 100 plans for different circle time sessions, different plans for both young and older children, activity sheets to use at the end of each session, and evaluation sheets to use at the end of the each theme.

All the activity and evaluation sheets can be printed from the new CD-Rom making it an ideal resource for those that want to use circle time but don't have time to plan the sessions.

This book is easily used in any setting and is a must-have for busy practitioners.

Children with low self-esteem will have difficulty in partaking in classroom lessons and succeeding. If we want to help children in the primary school to achieve the positive outcomes set out in the Every Child Matters agenda, we need to ensure all children have a healthy self-esteem. This book seeks to give adults in schools tools to look at the way they could enhance self esteem in children. The book comes with an accompanying CD-Rom which contains: - inset sessions for all adults in the school - workshops specifically aimed at non-teaching personnel, including mid-day supervisors - sessions for teachers and classroom assistants - classroom lessons and activity sheets for the children which can form part of your school's personal, social and health education (PSHE) programme. This book is a whole school training programme for raising self-esteem and is essential reading for all those working in primary education. Margaret Collins is a former headteacher of infant and first schools. She is now Senior Visiting Fellow in the School of Education at the University of Southampton. She researches children's perceptions of health education topics, writes teaching materials for children, books and articles on PSHE.

Following the success of Margarets book Because We're Worth It, she has developed a series of activity sheets for children to start work on in school and to complete at home with parent/ca/carer support. Not only do the activities involve the adult but they also emphasise the importance of families as promoters of self-esteem.

There are 10 sets of take home sheets covering:

" self identity

" self-worth

" body language

" intercommunication

" friendship

" feelings

" being confident

" empathy and sympathy

" relationships

" co-operation.

There are draft letters and explanatory notes for parents.

This is a book that will be extremely valuable to all staff who believe in enhancing self-esteem and in involving parents/ca/carers.

Margaret Collins is a former headteacher of an infant and first school. She is now Visiting Fellow in the School of Education at the University of Southampton. She researches children's perceptions of health education topics, writes and co-writes teaching materials for children, books and articles on personal, social, health and citizenship education (PSHCE).

From the author of our best-selling Circle Time for the Very Young comes another practical and exciting resource. Using the Circle Time framework Margaret has developed active ways to deliver elements of the PSHE and citizenship curriculum.

Using her ingenious format the author has presented four themes:

" personal education

" health education

" social education

" citizenship.

Each theme has 10 topics to cover the entire school year, and at two age levels on facing pages.

This delightfully illustrated and practical book will not be left lying around in the staff-room it is a pick-up-and-use publication

Margaret Collins is a former headteacher of an infant and first school. She is now Visiting Fellow in the School of Education at the University of Southampton. She researches children's perceptions of health education topics, writes and co-writes teaching materials for children, books and articles on personal, social, health and citizenship education (PSHCE).

Dehydrogenases are enzymes that play an important role in oxidation reactions. Dehydrogenases are involved in many metabolic pathways which maintain normal function and homeostasis of cells in the body. This book discusses the biochemistry of dehydrogenases, as well as their functions and roles in diseases.

Includes CD-Rom 'Nothing is so exhausting as indecision, and nothing is so futile' - Bertrand Russell .. and teachers, parents and carers worry that the decisions that children and young people make might be unwise or dangerous. Decision making is a skill involving both a cognitive and an affective process. The ability to: " recognize the thoughts and feelings; " consider the consequences; " choose the best outcome; is a highly valued facility leading to resilience, achievement and responsibility. The skill can be taught and in these three volumes the authors provide all the materials needed to teach a course on decision making at each age level. The programme provides a menu of stories related to the real life experiences of the young people. Topics are selected to be age appropriate and the series includes: " Stealing; " Lying; " Social behaviours; " Risks; " Justice; " Loss,Grief and Bereavement; " Prejudice; " First love; " Disability; " Leaving home; " Family relationships. The teacher notes indicate 'stopping points' where reflection and discussion is encouraged. A choice of endings is offered or the young people can develop their own ideas about what might happen next. The course can be introduced at any age or used to develop the skills through school life from early years to the teens. 'The need to work with children to help them understand the complexity of the place and the relationships within which they are growing up is greater than ever. This programme of stories, developed through Circle Time, gives a clear and challenging context for this work to develop' - Support For Learning 'You'd be hard pushed to find a better decision making programme than this excellent set of books... This series will undoubtedly kick-start conversation, prod thinking and stimulate classroom debate' - Times Educational Supplement Magazine Margaret Collins is a former headteacher of infant and first schools. She is now Senior Visiting Fellow in the School of Education at the University of Southampton. She researches children's perceptions of health education topics, writes teaching materials for children, books and articles on PSHE. Other books in the series include Tina Rae's Good Choices and Phil Carradice's Life Choices.

For any teacher or school wanting to set up a buddy scheme, or to explore the possibility of doing so, this book contains some useful suggestions, ideas and guidelines. Even if a school did not wish to adopt the buddy system itself, the book contains useful material relating to citizenship and specific problems, like bullying which makes it a potentially useful resource for teachers and schools in general' - "Early Education

"

Peer buddy systems have been demonstrated as very successful with older students. Positive effects are recognized for the individuals befriended and also for the whole community.

Margaret has used her vast experience with younger children to develop a programme which achieves these outcomes at the stage when they are learning the skills of friendship and co-operation.

Using her popular style of differentiating activities and teaching for two age groups, 6-8 and 9-11, Margaret has provided an exciting, innovative and challenging programme which enhances the citizenship curriculum and the atmosphere of the school.

Margaret Collins is a former headteacher of an infant and first school. She is now Visiting Fellow in the School of Education at the University of Southampton. She researches children's perceptions of health education topics, writes and co-writes teaching materials for children, books and articles on personal, social, health and citizenship education (PSHCE).

Written for anyone using Circle Time with 3 to 7 year olds, this book sets out strategies and activities for making the most out of Circle Time sessions. Pre and post-activities are included, to encourage children to focus on the content of Circle Time as a way of sharing their work, ideas and thoughts.

The book provides 11 different themes that can be linked to PSHCE, ranging from Caring for Others to Keeping Safe. Each theme provides:

o aims

o Circle Time activities

o Draw and Talk

o follow-up activities and suggestions for display

o resources

o reflections and evaluations.

Margaret Collins is a former headteacher of an infant and first school, and the author of the hugely popular 'Circle Time for the Very Young'. She is now Visiting Fellow in the School of Education at the University of Southampton. She researches children's perceptions of health education topics, writes and co-writes teaching materials for children, books and articles on personal, social, health and citizenship education (PSHCE).

What effect did the two world wars have on the relations between women and men? Drawing on broad comparative material-from government policy to popular media, poetry and fiction, and personal letters-this book examines the redefinition of gender that occurred in many Western countries during both world wars. "A major addition to the literature on gender relations and war."-Helena Lewis, Women's Review of Books "One of the first, and certainly the most exciting, treatments of war as an event of gender politics."-Choice "A substantial contribution to the social history of this century."-Anne Summers, Times Literary Supplement "These essays powerfully demonstrate how much the world wars provided battlegrounds not only for nations but for the sexes."-Michael S. Sherry, Annals of the American Academy of Political and Social Science "A work of lively, engaged scholarship.... This is an important contribution to current debates about war and human identity, war and political reality, war and transformative possibility."-Jean Bethke Elshtain

'An ideal resource to use when a child or children in a class are experiencing loss and grief. This area of work makes a vital contribution to bringing one of the most essential learning tasks of life into schools, helping children to recognise the universality of loss and encourage them to feel confident about their own and other people's feelings. If this book was used routinely across the country it would contribute to a significant shift in the environment in which children, and ultimately adults, are able to understand and deal with feelings. If you are a teacher please try and get hold of a copy' - Bereavement Care `Using stories about life events, Margaret Collins focuses on the needs of 4-9 year olds, and the ways in which they can express concerns, anxieties and grief. She also provides helpful advice for children and adults about how to help others when they are experiencing such difficulties' - SENCO Update When a child faces a problem with health or disability we are quick to offer support or change our expectations. Sadness, distress, anxiety, whether transient or long-term, can have significant effects on every child but they are invisible and the support or adjustments might not be in place. In this great resource Margaret uses stories about 20 different life events to: - illustrate the range of feelings - give permission for the expression of feelings - encourage empathy towards others - demonstrate that loss is a common experience for us all. The work balances an acknowledgement of the need to express sorrow and sadness with an opportunity to consider how to do something that is positive for oneself or helpful to others. Margaret Collins is a former headteacher of infant and first schools. She is now Senior Visiting Fellow in the School of Education at the University of Southampton. She researches children's perceptions of health education topics, writes teaching materials for children, books and articles on PSHE.

Schools are now asked to complete self-evaluation forms and update these annually. They not only require specific information about the views of learners, but also want to know how this information is gathered. Children's Voices provides a simple structure for gathering and assessing the views of pupils and parents/carers. This book will help to meet the school's needs in this evaluation and, in particular, to complete the SEFs which take into account the views of everyone connected with the schools including those of children. It is not only the collection of data and views that are important. When people are listened to they feel empowered with an improved view of their own self-worth. They, adults and children, feel that they belong to the community, have something to offer and are worthy of taking on some responsibility for the part they play in that community. As well as using data from the various sections in this book to complete the SEFs listening to what the children are telling us will improve our teaching or techniques to meet their needs. Listening to children's voices is only the first step. It is the action we take about what they say that is important. Who is Children's Voices for? Children's Voices is designed as a programme for teachers in mainstream schools. It will also be useful for teachers of children with special needs and classroom assistants working with individual children or very small groups. It is also suitable for use in special schools and with students in training establishments.