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Light the Wings, Remove the Non-Existent Speed is a book of poetry
that pushes against the everyday ordinary. It encourages us to look
out for all this world has to offer, drop what makes us slower, and
find the lights that certainly help us see a little more.
Proteins are the cell's workers, their messengers and overseers. In
these roles, proteins specifically bind small molecules, nucleic
acid and other protein partners. Cellular systems are closely
regulated and biologically significant changes in populations of
particular protein complexes correspond to very small variations of
their thermodynamics or kinetics of reaction. Interfering with the
interactions of proteins is the dominant strategy in the
development of new pharmaceuticals. Protein Ligand Interactions:
Methods and Applications, Second Edition provides a complete
introduction to common and emerging procedures for characterizing
the interactions of individual proteins. From the initial discovery
of natural substrates or potential drug leads, to the detailed
quantitative understanding of the mechanism of interaction, all
stages of the research process are covered with a focus on those
techniques that are, or are anticipated to become, widely
accessible and performable with mainstream commercial
instrumentation. Written in the highly successful Methods in
Molecular Biology series format, chapters contain introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and notes on troubleshooting and avoiding known pitfalls.
Authoritative and accessible, Protein Ligand Interactions: Methods
and Applications, Second Edition serves as an ideal guide for
researchers new to the field of biophysical characterization of
protein interactions - whether they are beginning graduate students
or experts in allied areas of molecular cell biology, microbiology,
pharmacology, medicinal chemistry or structural biology.
Human beings have succeeded as the most dominant species on earth
in large part due to our need to connect and cooperate. It was our
ability to socialize and connect that catapulted our species to
phenomenal heights of innovation, through collaboration and
specialization. This drive has fine-tuned our unconscious
perception of faces, facial expressions, body language, and touch.
Our primitive drive to connect changes how we perceive the world
and the people around us. We see, hear, empathize with, and
understand others differently depending on whether they are a
member of our in-group or not. This unconscious drive to connect
can draw us together, but it also emphasizes the differences
between groups. And it is getting worse, as overcrowding,
technology, and the media often focus us on our differences. We
become more and more divided into groups as a result. Here, Mark
Williams shows us how to recapture the drive for connection in a
way that will help us look past our differences and reconnect, even
with those whom we perceive to be outside our groups. He starts by
discussing the human brain's specialization for connection and how
it evolved, and the fascinating way we automatically process the
thoughts and feelings of others. He focuses on how connection works
in practice and why it is important for learning, innovating,
health and wellbeing. He then explores the negative consequences of
our drive for connection and explains how it contributes to racism,
sexism, nationalism, and many other social issues of our day, as
well as its impact on our individual health and wellbeing. He ends
with a positive perspective by examining how we can use our drive
for connection to expand our in-group and extend multicultural
societies for the good of our planet.
This third edition provides new and updated chapters detailing a
complete introduction to common and emerging procedures for
characterizing the interactions of individual proteins with their
natural ligands, drugs or other binding partners. Chapters detail
natural substrates, potential drug leads, quantitative
understanding of the mechanism of interaction, and different
techniques. Written in the highly successful Methods in Molecular
Biology series format, chapters include introductions to their
respective topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and tips
on troubleshooting and avoiding known pitfalls. Authoritative and
accessible, Protein Ligand Interactions: Methods and Applications,
Third Edition serves as an ideal guide for researchers new to the
field of biophysical characterization of protein interactions.
This third edition provides new and updated chapters detailing a
complete introduction to common and emerging procedures for
characterizing the interactions of individual proteins with their
natural ligands, drugs or other binding partners. Chapters detail
natural substrates, potential drug leads, quantitative
understanding of the mechanism of interaction, and different
techniques. Written in the highly successful Methods in Molecular
Biology series format, chapters include introductions to their
respective topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and tips
on troubleshooting and avoiding known pitfalls. Authoritative and
accessible, Protein Ligand Interactions: Methods and Applications,
Third Edition serves as an ideal guide for researchers new to the
field of biophysical characterization of protein interactions.
Proteins are the cell's workers, their messengers and overseers. In
these roles, proteins specifically bind small molecules, nucleic
acid and other protein partners. Cellular systems are closely
regulated and biologically significant changes in populations of
particular protein complexes correspond to very small variations of
their thermodynamics or kinetics of reaction. Interfering with the
interactions of proteins is the dominant strategy in the
development of new pharmaceuticals. Protein Ligand Interactions:
Methods and Applications, Second Edition provides a complete
introduction to common and emerging procedures for characterizing
the interactions of individual proteins. From the initial discovery
of natural substrates or potential drug leads, to the detailed
quantitative understanding of the mechanism of interaction, all
stages of the research process are covered with a focus on those
techniques that are, or are anticipated to become, widely
accessible and performable with mainstream commercial
instrumentation. Written in the highly successful Methods in
Molecular Biology series format, chapters contain introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and notes on troubleshooting and avoiding known pitfalls.
Authoritative and accessible, Protein Ligand Interactions: Methods
and Applications, Second Edition serves as an ideal guide for
researchers new to the field of biophysical characterization of
protein interactions - whether they are beginning graduate students
or experts in allied areas of molecular cell biology, microbiology,
pharmacology, medicinal chemistry or structural biology.
*Exploits new features of Visual Studio .NET 2003 and the Oracle
database 10g. (But concepts and code still apply to the earlier
releases, 8i and 9i, that currently comprise most business
systems). *Explains Oracle programming using both C# and VB.NET
languages; provides a one-stop reference for VS.NET developers
working with Oracle. *Excellent resource for J2EE programmers in
environments considering moving to a .NET environment (and
retaining the Oracle database).
Light the Wings, Remove the Non-Existent Speed is a book of poetry
that pushes against the everyday ordinary. It encourages us to look
out for all this world has to offer, drop what makes us slower, and
find the lights that certainly help us see a little more.
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