Protein-Ligand Interactions - Methods and Applications (Paperback, Softcover reprint of the original 2nd ed. 2013)

Proteins are the cell's workers, their messengers and overseers. In these roles, proteins specifically bind small molecules, nucleic acid and other protein partners. Cellular systems are closely regulated and biologically significant changes in populations of particular protein complexes correspond to very small variations of their thermodynamics or kinetics of reaction. Interfering with the interactions of proteins is the dominant strategy in the development of new pharmaceuticals. Protein Ligand Interactions: Methods and Applications, Second Edition provides a complete introduction to common and emerging procedures for characterizing the interactions of individual proteins. From the initial discovery of natural substrates or potential drug leads, to the detailed quantitative understanding of the mechanism of interaction, all stages of the research process are covered with a focus on those techniques that are, or are anticipated to become, widely accessible and performable with mainstream commercial instrumentation. Written in the highly successful Methods in Molecular Biology series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Protein Ligand Interactions: Methods and Applications, Second Edition serves as an ideal guide for researchers new to the field of biophysical characterization of protein interactions - whether they are beginning graduate students or experts in allied areas of molecular cell biology, microbiology, pharmacology, medicinal chemistry or structural biology.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Biology, 1008
Release date:	November 2016
First published:	2013
Editors:	Mark A. Williams • Tina Daviter
Dimensions:	254 x 178 x 28mm (L x W x T)
Format:	Paperback
Pages:	530
Edition:	Softcover reprint of the original 2nd ed. 2013
ISBN-13:	978-1-4939-5873-3
Categories:	Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
LSN:	1-4939-5873-9
Barcode:	9781493958733

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