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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Protein-Ligand Interactions - Methods and Applications (Hardcover, 2nd ed. 2013)
Loot Price: R5,713
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Protein-Ligand Interactions - Methods and Applications (Hardcover, 2nd ed. 2013)
Series: Methods in Molecular Biology, 1008
Expected to ship within 10 - 15 working days
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Proteins are the cell's workers, their messengers and overseers. In
these roles, proteins specifically bind small molecules, nucleic
acid and other protein partners. Cellular systems are closely
regulated and biologically significant changes in populations of
particular protein complexes correspond to very small variations of
their thermodynamics or kinetics of reaction. Interfering with the
interactions of proteins is the dominant strategy in the
development of new pharmaceuticals. Protein Ligand Interactions:
Methods and Applications, Second Edition provides a complete
introduction to common and emerging procedures for characterizing
the interactions of individual proteins. From the initial discovery
of natural substrates or potential drug leads, to the detailed
quantitative understanding of the mechanism of interaction, all
stages of the research process are covered with a focus on those
techniques that are, or are anticipated to become, widely
accessible and performable with mainstream commercial
instrumentation. Written in the highly successful Methods in
Molecular Biology series format, chapters contain introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and notes on troubleshooting and avoiding known pitfalls.
Authoritative and accessible, Protein Ligand Interactions: Methods
and Applications, Second Edition serves as an ideal guide for
researchers new to the field of biophysical characterization of
protein interactions - whether they are beginning graduate students
or experts in allied areas of molecular cell biology, microbiology,
pharmacology, medicinal chemistry or structural biology.
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