This issue of Anesthesiology Clinics, edited by Drs. Maureen McCunn, Mohammed Iqbal Ahmed, and Catherine M. Kuza is dedicated to Cutting-Edge Trauma and Emergency Care. Topics in this issue include: Recognizing preventable death: the role of survival prediction algorithms; ATLS (R) Update 2019: Adult management and applications to pediatric trauma care; Induction agents in specific trauma situations: RSI versus 'slow sequence intubation': Considerations for cervical spine, massive facial trauma, and tracheal disruption; Hemorrhage control and the anesthesiologist: resuscitative endovascular occlusion (REBOA) and emergency perfusion resuscitation (EPR); TEG/ROTEM as a guide for massive transfusion of patients with life-threatening hemorrhage; The anesthesiologist's response to a multiple casualty-incident: our roles working through Hurricanes Irma and Harvey; When the provider becomes the victim: how to prepare for an active shooter in the trauma center; Non-accidental pediatric injuries, pediatric TBI, and sports concussions; Gender disparities in trauma care: how sex determines treatment, behavior, and the outcome; Pain management in trauma in the age of the opioid crisis; The use of point of care ultrasound (PoCUS) in trauma anesthesia care; Post-intensive care syndrome (PICS) and posttraumatic stress disorder (PTSD) in trauma patients; Enhanced recovery after surgery: Are ERAS principles applicable to adult and geriatric trauma and acute care surgery?; and Future trends in trauma care: lessons from current research and treatment strategies in the military.