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In this state-of-the-art exploration of a hugely dynamic and
fast-evolving field of research, leading researchers share their
collective wisdom on the role that stem cells could play in the
context of physiological stress and lung injury. The text focuses
on reviewing the most relevant-and recent-ideas on using local,
endogenous, and exogenous progenitor/stem cells in preventing and
treating injury to the lung. The lungs are one of the most complex
organs in the human body, with a mature adult lung boasting at
least 40 morphologically differentiated cell lineages. Our entire
blood supply passes through the lung's alveolar units during
oxygenation. This interaction with the outside world, along with
the intricacies of its structure, makes the lung a highly
susceptible organ that is vulnerable to numerous types of injury
and infection. This means that the mechanisms of lung repair are in
themselves correspondingly complex. Because of their
multipotentiality, as well as the fact of the lung's relatively
rapid cell turnover, stem cells are thought to be an important
alternative cell-base therapy in lung injury. Despite the
controversial nature of stem cell research, there has been growing
interest in both local and endogenous stem cells in the lung. This
highly topical book with chapters on everything from using
mesenchymal stem cells in lung repair to the effect of physical
activity on the mobilization of stem and progenitor cells,
represents an exciting body of work by outstanding investigators
and will be required reading for those with an interest in the
subject.
In this state-of-the-art exploration of a hugely dynamic and
fast-evolving field of research, leading researchers share their
collective wisdom on the role that stem cells could play in the
context of physiological stress and lung injury. The text focuses
on reviewing the most relevant-and recent-ideas on using local,
endogenous, and exogenous progenitor/stem cells in preventing and
treating injury to the lung. The lungs are one of the most complex
organs in the human body, with a mature adult lung boasting at
least 40 morphologically differentiated cell lineages. Our entire
blood supply passes through the lung's alveolar units during
oxygenation. This interaction with the outside world, along with
the intricacies of its structure, makes the lung a highly
susceptible organ that is vulnerable to numerous types of injury
and infection. This means that the mechanisms of lung repair are in
themselves correspondingly complex. Because of their
multipotentiality, as well as the fact of the lung's relatively
rapid cell turnover, stem cells are thought to be an important
alternative cell-base therapy in lung injury. Despite the
controversial nature of stem cell research, there has been growing
interest in both local and endogenous stem cells in the lung. This
highly topical book with chapters on everything from using
mesenchymal stem cells in lung repair to the effect of physical
activity on the mobilization of stem and progenitor cells,
represents an exciting body of work by outstanding investigators
and will be required reading for those with an interest in the
subject.
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