The Chromosome 22q11.2 Deletion Syndrome: A Multidisciplinary Approach to Diagnosis and Treatment serves as the first comprehensive, user-friendly resource on the etiology, prognosis, and recurrence risk associated with the chromosome 22q11.2 deletion syndrome. Leading international contributors cover the background, genetics, testing methods, and pathophysiology of 22q11.2DS, placing emphasis on a strong foundation for multidisciplinary treatment strategies. Written by specialists in every applicable subspecialty, such as, cardiology, immunology, endocrinology, gastroenterology, hematology, ophthalmology, neurology, and psychiatry, among other fields. This book presents an authoritative resource with full color images that enhance concept illustration and aid in real-time decision-making. As 22q11.2 deletion syndrome has become a model for understanding rare and frequent anomalies, numerous medical issues, cognitive and behavioral phenotypes, and later onset conditions, this text will become the go to resource for clinicians, researchers, trainees, and motivated family members, in gaining a full understanding of this complex chromosomal disorder.

Disgust has a strong claim to be a distinctively human emotion. But what is it to be disgusting? What unifies the class of disgusting things? Colin McGinn sets out to analyze the content of disgust, arguing that life and death are implicit in its meaning. Disgust is a kind of philosophical emotion, reflecting the human attitude to the biological world. Yet it is an emotion we strive to repress. It may have initially arisen as a method of curbing voracious human desire, which itself results from our powerful imagination. Because we feel disgust towards ourselves as a species, we are placed in a fraught emotional predicament: we admire ourselves for our achievements, but we also experience revulsion at our necessary organic nature. We are subject to an affective split. Death involves the disgusting, in the shape of the rotting corpse, and our complex attitudes towards death feed into our feelings of disgust. We are beings with a "disgust consciousness," unlike animals and gods-and we cannot shake our self-ambivalence. Existentialism and psychoanalysis sought a general theory of human emotion; this book seeks to replace them with a theory in which our primary mode of feeling centers around disgust. The Meaning of Disgust is an original study of a fascinating but neglected subject, which attempts to tell the disturbing truth about the human condition.

'Packed full of emotional wisdom, heartbreak and hope. Wonderful - I loved it.' Daily Mail A story about friends, sisters, motherhood and starting again - one day at a time... Stella fell in love with Simon hard and fast. He was everything she wanted in a husband, and he seemed to feel the same way about her. More than a decade of marriage later, life is sweet. They have three much-wanted children, a successful business, and a comfortable London home. What more could Stella possibly want? But then, out of the blue, Simon is gone. Vanished. No one knows where he's gone or why. Now Stella, with the help of her friends and family, has to pick up the pieces of her and her children's life, all the while wondering what she missed. Was her husband who he said he was, and can she trust her own memories of their life together? Helen McGinn's latest novel is a love story to friendship, sisters, motherhood and starting again - one day at a time. Perfect for fans of Elizabeth Noble, Cathy Kelly and JoJo Moyes. Praise for Helen McGinn: 'This is McGinn's third novel and it's her best yet. Packed full of emotional wisdom, heartbreak and hope and is particularly brilliant on the importance of friendship and taking things one day at a time. Wonderful - I loved it.' Daily Mail 'This is a lovely uplifting book that transported me away, firstly to the beautiful city of Rome and then to gorgeous Cornwall. It's a moving and emotional story of families in all their messy wonderfulness, of people losing one another, and then coming together again - sometimes in unexpected ways. A hugely enjoyable family tale, it was exactly what I wanted to read at this time.' Louise Douglas 'This Changes Everything is the perfect tonic. An uplifting, forget-about-everything-else read that I couldn't put down. Romantic, emotional and page-turning, Helen McGinn's debut novel can't fail to cheer you up!' Zoe Folbigg 'I loved reading this book. I needed escapism and it gave me Rome, Cornwall and a family who immediately felt like old friends. I took it to the bath, to bed and had finished it within 24 hours. It was the perfect antidote to tough times.' Victoria Moore The Daily Telegraph

This casebook presents representative texts from Roman legal sources that introduce the basic problems arising in Roman families, including marriage and divorce, the pattern of authority within households, the transmission of property between generations, and the supervision of orphans.

Since the middle of the 20th century Ludwig Wittgenstein has been an exceptionally influential and controversial figure wherever philosophy is studied. This is the most comprehensive volume ever published on Wittgenstein: thirty-five leading scholars explore the whole range of his thought, offering critical engagement and original interpretation, and tracing his philosophical development. Topics discussed include logic and mathematics, language and mind, epistemology, philosophical methodology, religion, ethics, and aesthetics. Wittgenstein's relation to other founders of analytic philosophy such as Gottlob Frege, Bertrand Russell, and G. E. Moore is explored. This Handbook is the place to look for a full understanding of Wittgenstein's special importance to modern philosophy.

The authors of this book explain how decisions about education and educational policymaking can be informed by research-based knowledge. They develop a framework to organize three approaches, which are: policy dialogue as persuasion, policy dialogue as negotiation, and policy dialogue as participation and organizational learning. The book includes a nine-stage model for how best to employ research to influence this type of learning using a participatory approach. A current review of literature in research utilization in education is also discussed.

'Escapist, warm, witty and wise' Daily MailShould first love be left in the past, or is first love, forever love...Sisters Annie and Jess are used to their mother Julia being spontaneous. But when Julia announces she's flying off to Rome to meet her first love Patrick, whom she hasn't seen for fifty years, it's an adventure too far. So, her daughters decide the only way to keep Julia safe, is to go too - without actually telling their mother she has chaperones! Julia and Patrick's love story was everything - epic, once-in-a-lifetime, with a tragic ending and life-long consequences. First love is hard to forget, but sometimes, just sometimes, life delivers a chance to rewrite your story. As the eternal city of Rome works its magic, old secrets, old friends and old loves become new possibilities and new dreams. And when the four travellers return home, nothing will ever be the same again. Join Helen McGinn for a timeless, joyous, unforgettable journey through love, family, and long-forgotten dreams. A novel to hold to your heart and treasure, perfect for fans of Elizabeth Noble, Cathy Kelly and JoJo Moyes. Praise for This Changes Everything: 'This is a lovely, uplifting book that transported me away, firstly to the beautiful city of Rome and then to gorgeous Cornwall. It's a moving and emotional story of families in all their messy wonderfulness, of people losing one another, and then coming together again - sometimes in unexpected ways. A hugely enjoyable family tale, it was exactly what I wanted to read at this time.' Louise Douglas 'This Changes Everything is the perfect tonic. An uplifting, forget-about-everything-else read that I couldn't put down. Romantic, emotional and page-turning, Helen McGinn's debut novel can't fail to cheer you up!' Zoe Folbigg 'I loved reading this book. I needed escapism - don't we all need escapism right now - and it gave me Rome, Cornwall and a family who immediately felt like old friends. I took it to the bath, to bed and had finished it within 24 hours. It was the perfect antidote to tough times.' Victoria Moore, The Daily Telegraph

What makes the Ultimate Scot? Is it the ability to identify a tartan pattern from 50 yards? Maybe it’s being able to recite the two forgotten verses of ‘Auld Lang Syne’? Or perhaps it’s knowing your single malt from a double malt? The Ultimate Guide to Being Scottish examines in hilarious detail the history, politics and traditions that make Scots great. Exploring the best of Scottish culture, this book focuses on the celebrations that Scots have made their own, from Hogmanay to the Edinburgh Fringe festival. Mixing fact and practical hints (like the ideal recipe for boiled sheep’s head) with witty banter, The Ultimate Guide to Being Scottish is perfect for injecting Scotland’s unique and beloved brand of merriment into the year.

The Making of a Philosopher follows Colin McGinn from his early years in England, reading Descartes and Anselm, to his years in the States, first in Los Angeles, then New York. McGinn presents a contemporary academic take on the great philosophical figures of the twentieth century -- including Bertrand Russell, Jean-Paul Sartre, and Noam Chomsky -- alongside stories of the teachers who informed his ideas and often became friends and mentors, especially the colorful A. J. Ayer at Oxford.

Always elegant and probing, The Making of a Philosopher is for the student of contemporary philosophy as well as the general reader. Both will absorb every page.

Knowledge and Reality brings together a selection of Colin McGinn's philosophical essays from the 1970s to the 1990s, whose unifying theme is the relation between the mind and the world. The essays range over a set of prominent topics in contemporary philosophy, including the analysis of knowledge, the a priori, necessity, possible worlds, realism, mental representation, appearance and reality, and colour. McGinn has written a new postscript to each essay, placing it in its philosophical context by sketching the background against which it was written, explaining its relations to other notable work, and offering his current reflections on the topic. The volume thus traces the development of McGinn's ideas and their role in some central philosophical debates. Seen together the essays offer a many-sided defence of realism, while emphasizing the epistemological price that realism exacts.

Apocalypticism has been the source of hope and courage for the oppressed, but has also given rise, on many occasions, to fanaticism and intolerance. The essays in this volume seek neither to apologize for the extravagance of apocalyptic thinkers nor to excuse the perverse actions of some of their followers. Rather, they strive to understand a powerful, perhaps even indispensable, element in the history of Western religions that has been the source of both good and evil, and still is yet today.The Editors The Continuum History of Apocalypticism is a 1-volume, select edition of the 3-vol. Encyclopedia of Apocalypticism first published in 1998. The main historical surveys that provided the spine of the Encyclopedia have been retained, while essays of a thematic nature, and a few whose subject matter is not central to the historical development, have been omitted. The work begins with 8 articles on The Origins of Apocalypticism in the Ancient World, extending from ancient Near Eastern myth through the Old Testament to the Dead Sea Scrolls, Jesus, Paul, and the Book of Revelation. Next are 7 articles on Apocalyptic Traditions from Late Antiquity to ca. 1800 C.E., including early Christian theology, radical movements in the Middle Ages, and both Jewish and Islamic apocalypticism in the classic period. The final section, Apocalypticism in the Modern Age, includes 10 articles on apocalypticism in the Americas, in Western and Eastern Europe, and, finally, in modern Judaism and modern Islam.

What kind of subject is philosophy? Colin McGinn takes up this perennial question, defending the view that philosophy consists of conceptual analysis, construed broadly. Conceptual analysis is understood to involve the search for de re essences, but McGinn takes up various challenges to this meta-philosophy: that some concepts are merely family resemblance concepts with no definition in terms of necessary and sufficient conditions ("game," "language"); that it is impossible to provide sufficient conditions for some philosophically important concepts without circularity ("knowledge," "intentional action"); that there exists an unsolved paradox of analysis; that there is no well-defined analytic-synthetic distinction; that names have no definition; and that conceptual analysis is not properly naturalistic. Ultimately, McGinn finds none of these objections convincing: analysis emerges as both possible and fruitful.
At the same time, he rejects the idea of the "linguistic turn," arguing that analysis is not directed to language as such, but at reality. Going on to distinguish several types of analysis, with an emphasis on classical decompositional analysis, he shows different philosophical traditions to be engaged in conceptual analysis when properly understood. Philosophical activity has the kind of value possessed by play, McGinn claims, which differs from the kind of value possessed by scientific activity. The book concludes with an analytic discussion of the prospects for traditional ontology and the nature of instantiation.
McGinn's study of the nature of philosophy shows us how philosophy can maintain its connection to the past while looking forward to a bright future.

Crossing Lines analyzes the experiences of more than 25 education research networks spanning Africa, Latin America, Asia, and Europe. Their history yields rich insights into the construction and maintenance of communication structures and processes that increase the utility, and the utilization, of education policy research. Networks are difficult to establish and difficult to maintain. But if maintained, they facilitate effective communication between the various members, leading to generation of shared conceptions of what is important, and how best to go about achieving it. The networks described in this book are intended to help researchers identify problems and design research that is relevant to the countries in which they work. The networks also are intended to help decision-makers identify information that is available, and to signal the kind of information required in the future. This book is an important research and professional tool for educators and education policy-makers, both in national governments and in international assistance agencies.

In Basic Structures of Reality, Colin McGinn deals with questions of metaphysics, epistemology, and philosophy of mind from the vantage point of physics. Combining general philosophy with physics, he covers such topics as the definition of matter, the nature of space, motion, gravity, electromagnetic fields, the character of physical knowledge, and consciousness and meaning. Throughout, McGinn maintains an historical perspective and seeks to determine how much we really know of the world described by physics. He defends a version of "structuralism": the thesis that our knowledge is partial and merely abstract, leaving a large epistemological gap at the center of physics. McGinn then connects this element of mystery to parallel mysteries in relation to the mind. Consciousness emerges as just one more mystery of physics. A theory of matter and space is developed, according to which the impenetrability of matter is explained as the deletion of volumes of space. McGinn proposes a philosophy of science that distinguishes physics from both psychology and biology, explores the ontology of energy, and considers the relevance of physics to seemingly remote fields such as the theory of meaning. In the form of a series of aphorisms, the author presents a metaphysical system that takes laws of nature as fundamental. With its broad scope and deep study of the fundamental questions at the heart of philosophy of physics, this book is not intended primarily for specialists, but for the general philosophical reader interested in how physics and philosophy intersect.

This annual celebration of the life and works of the poet Robert Burns is held in Scotland and across the globe around the anniversary of the poet's birthday in the form of a convivial dinner with particular, some may say peculiar, ritual traditions. Robert Burns: Scotland's national poet. Burns Supper: the celebration of the life and poetry of Robert Burns, on or around his birthday on 25 January every year. When the Reverend Hamilton Paul agreed to arrange the first anniversary dinner for Robert Burns' patrons and friends in July 1801, he began a tradition that quite soon became a global celebration. Over two hundred years later, Burns Suppers are held all over the world to commemorate the life and work of a poet beloved wherever people celebrate life, love and liberty. From its beginning with nine Scotsmen in Burns Cottage, to today, where over nine million people join in the Burns Supper festivities, from the USA to Russia, Australia to China, and somewhere near you. The long and happy story of Burns Night is explored in this history of the annual event which has been called 'the biggest party in the world'.

Knowledge and Reality brings together a selection of Colin McGinn's philosophical essays from the 1970s to the 1990s, whose unifying theme is the relation between the mind and the world. McGinn defends a realist view, but emphasizes the epistemological problems that come with it. He has written a new postscript to each essay, placing it in its philosophical context and offering his current reflections on the topic.

Identity, existence, predication, necessity, and truth are fundamental philosophical concerns. Colin McGinn treats them both philosophically and logically, aiming for maximum clarity and minimum pointless formalism. He contends that there are real logical properties that challenge naturalistic metaphysical outlooks. These concepts are not definable, though we can say a good deal about how they work. The aim of Logical Properties is to bring philosophy back to philosophical logic.

Aimed at philsophy graduates this book investigates mental content in a systematic way and advances a number of claims about how mental content states are related to the body and the world. Internalism is the thesis that they are; externalism is the theory that they are not. The critical disagreement between these two theses concerns their differing conceptions of the relation between the mind and the world. Is the mind fundamentally autonomous with respect to the world, or does the world enter into the very nature of mind? This study offers an original account of the dilemma and proposes significant advances in the disputes about mind and brain, personality, externalism and internalism, and teleological explanations.

Wittgenstein is one of the most important and influential twentieth-century philosophers in the western tradition. In his Philosophical Investigations he undertakes a radical critique of analytical philosophy's approach to both the philosophy of language and the philosophy of mind. The Routledge Guidebook to Wittgenstein's Philosophical Investigations introduces and assesses: Wittgenstein's life The principal ideas of the Philosophical Investigations Some of the principal disputes concerning the interpretation of his work Wittgenstein's philosophical method and its connection with the form of the text. With further reading included throughout, this guidebook is essential reading for all students of philosophy, and all those wishing to get to grips with this masterpiece.

When did Burns Suppers start? Why is it celebrated all over the world? Who can join in the fun? Spanning the history of the phenomenon, from the year of its creation in 1801 to the present day, this book offers you everything you need to know about the Burns Supper, and the poet for whom it is held every year. From the origins of the custom to its modern day interpretations, from the rituals and traditions to the fun and fellowship, this first full-length study of the unique annual celebration of Scotland's national poet answers every question you can think of, along with every one you can't.

A year and a half after seeing the blacktop brothers last, Paige and David's lives have been more than adequate, but overrated in several ways, fear and sleep most of all. The jail break and flight to the Rocky Mountains right before Christmas wouldn't have been their problem if they didn't have a deadly and unknown weapon only the DPA knew heck about. They must now find the loose teens again to protect the city and create a new contraption that may or may not be necessary in the end, with obnoxious cops not just after the vandal gang...