That concern about human genetics is at the top of many lists of issues requiring intense discussion from scientific, political, social, and ethical points of view is today no surprise. It was in the spirit of attempting to establish the basis for intelligent discussion of the issues involved that a group of us gathered at a meeting of the International Society for the History, Philosophy, and Social Studies of Biology in the Summer of 1995 at Brandeis University and began an exploration of these questions in earlier versions of the papers presented here. Our aim was to cross disciplines and jump national boundaries, to be catholic in the methods and approaches taken, and to bring before readers interested in the emerging issues of human genetics well-reasoned, informative, and provocative papers. The initial conference and elements of the editorial work which have followed were generously supported by the Stifterverband fUr die Deutsche Wissenschaft. We thank Professor Peter Weingart of Bielefeld University for his assistance in gaining this support. As Editors, we thank the anonymous readers who commented upon and critiqued many of the papers and in tum made each paper a more valuable contribution. We also thank the authors for their understanding and patience. Michael Fortnn Everett Mendelsohn Cambridge, MA September 1998 vii INTRODUCTION In 1986, the annual symposium at the venerable Cold Spring Harbor laboratories was devoted to the "Molecular Biology of Homo sapiens.

In this provocative new book, Michael Fortun and Herbert J. Bernstein explore the processes of science and the complex interacting forces that determine how ideas, observations, collections of data, and expert interpretations are shaped into the kind of scientific fact that is so commonly accepted as a neutral basis for social policy. Messy. Clumsy. Volatile. Exciting. These words are not often associated with the sciences, which for most people still connote exactitude, elegance, reliability, and a rather plodding certainty. But the real story is something quite different. The sciences are less about the ability to know and to control than they are about the unleashing of new forces, new capacities for changing the world. The sciences as practiced exist not in some pristine world of objectivity, but in what Mike Fortun and Herb Bernstein call the muddled middle.This book explores the way science makes sense of the world and how the world makes sense of science. It is also about politics and culture--how these forces shape the sciences and are shaped by it in turn. Think of Muddling Through as the basic text for a new kind of literacy project, a project to re-imagine the sciences as complex operations of language, action, and thought--as attempts, trials, limited experiments.The sciences provide us with the images and metaphors we apply to myriad situations and phenomena, and create the blueprints we use to make and legitimate crucial social decisions. If democracies are to meet the challenge of the ever more critical world-making role of the sciences, they must fundamentally shift their attention and their attitudes. The quest for social or political mastery of the sciences will have to end; the new journey will begin with a trip to the muddled middle.Travel then, with historian Fortun and physicist Bernstein from the workshops of fifteenth-century England to a present-day quantum physics laboratory. Stop at a military toxic waste dump, a courtroom, a colony of baboons. Along the way you might shed your faith in pure inquiry, see the limits of value-free rationality, and breath the fresh air of change.

That concern about human genetics is at the top of many lists of issues requiring intense discussion from scientific, political, social, and ethical points of view is today no surprise. It was in the spirit of attempting to establish the basis for intelligent discussion of the issues involved that a group of us gathered at a meeting of the International Society for the History, Philosophy, and Social Studies of Biology in the Summer of 1995 at Brandeis University and began an exploration of these questions in earlier versions of the papers presented here. Our aim was to cross disciplines and jump national boundaries, to be catholic in the methods and approaches taken, and to bring before readers interested in the emerging issues of human genetics well-reasoned, informative, and provocative papers. The initial conference and elements of the editorial work which have followed were generously supported by the Stifterverband fUr die Deutsche Wissenschaft. We thank Professor Peter Weingart of Bielefeld University for his assistance in gaining this support. As Editors, we thank the anonymous readers who commented upon and critiqued many of the papers and in tum made each paper a more valuable contribution. We also thank the authors for their understanding and patience. Michael Fortnn Everett Mendelsohn Cambridge, MA September 1998 vii INTRODUCTION In 1986, the annual symposium at the venerable Cold Spring Harbor laboratories was devoted to the "Molecular Biology of Homo sapiens.