This book challenges dominant thinking about early career teachers and their work. It offers an in-depth and critical analysis of policies concerning the work of early career teachers and how they are supported during this critical period, when they are highly vulnerable to leaving the profession. Moreover, the book provides examples from actual practice that illustrate how to help early career teachers make a successful transition into the profession. These practices promote early career teachers' development and help the profession as a whole to capitalize on the new knowledge and skills that these teachers bring to their classrooms and their students. The book is divided into two main parts. Part 1 deals with the difficult to define process of retaining early career teachers, and its respective chapters consider this broad issue from an international perspective. They explore how policies and practices have an impact on what happens in schools, and what it means to be a teacher and to teach. In turn, Part 2 focuses on the need to reconsider the policies and practices that create the 'problem' of early career teachers, and offers alternative ways forward. Each chapter addresses a specific aspect of the early career teacher retention issue, contributing to a greater understanding of how we can rethink the work of early career teachers so that they can more successfully transition into the profession.

Angiogenesis and Cardiovascular Disease provides a comprehensive review of the basic scientific and clinical advances in the field of angiogenesis, and its role in the human cardiovascular system. The material presented draws from multiple disciplines, integrating information in a single source. Topics addressed focus first on aspects of development and normal biology of the vasculature, and then on angiogenesis and how it is involved in the pathophysiology and therapy of ischemic cardiovascular disease. Vascular development, endothelial cell biology, the vascular matrix, and growth factors are discussed. Up to date information on current clinical trials, and practical advice concerning application to cardiovascular therapeutic options, are also stressed.

The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states.Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches.With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments - endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer.It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.

In April 1863 after the U.S. Dakota War of 1862, after the hanging of thirty-eight Dakota men in the largest mass execution in U.S. History some 270 Dakota men were moved from Mankato, Minnesota, to a prison at camp McClellan in Davenport, Iowa. Separated from their wives, children, and elder relatives, with inadequate shelter, they lived there for three long, wretched years. More than 120 men died. Desperate to connect with their families, many of these prisoners of war learned to write. Their letters, mostly addressed to the missionaries Stephen R Riggs and Thomas S. Williamson, asked for information, for assistance, and for help sending and receiving news of their loved ones. Dakota elders Clifford Canku and Michael Simon, fluent Dakota speakers, provide both the Dakota transcription and the first published English translation of fifty of these letters, culled from Riggs's papers at the Minnesota historical society. They are a precious resource for Dakota people learning about the travails their ancestors faced, important primary source documents for historians, and a vital tool for Dakota language learners and linguists. These haunting documents present a history that has long been unrecognised in this country, in the words of the Dakota people who lived it. The dedication written by the authors, both of whom are descendants of Dakota prisoners of war, declares: "Our relatives are watching over us. / We are humbled as we honour our ancestors. / Woecon kin de unyakupi do / We accept this responsibility you gave us".

Dieses Buch bietet eine Untersuchung des Einflusses neoliberaler Denkmuster auf die deutsche Gesundheitspolitik seit 1945. Der Einfluss wird untersucht und aufgezeigt am Beispiel der gesetzlichen Krankenversicherung, die von zentraler Bedeutung für das deutsche Gesundheitswesen ist.Das Buch wendet sich an alle Wissenschaftsdisziplinen, die sich mit Gesundheitspolitik und insbesondere Fragen der Ausgestaltung der gesetzlichen Krankenversicherung befassen. Darüber hinaus bietet es auch Akteuren der Gesundheitspolitik vielfältiges Material und Hintergrundwissen über die historische Entwicklung der Gesundheitspolitik und zentrale Fragen der Ausgestaltung der gesetzlichen Krankenversicherung. Mit seinem Erscheinen in der Reihe „Gesundheit. Politik-Gesellschaft-Wirtschaft“ (hrsg. von E.-W. Luthe und J.N. Weatherly) steht das Buch für die wachsende Erkenntnis, Gesundheitspolitik als interdisziplinäre Aufgabe zu betrachten.

This book challenges dominant thinking about early career teachers and their work. It offers an in-depth and critical analysis of policies concerning the work of early career teachers and how they are supported during this critical period, when they are highly vulnerable to leaving the profession. Moreover, the book provides examples from actual practice that illustrate how to help early career teachers make a successful transition into the profession. These practices promote early career teachers' development and help the profession as a whole to capitalize on the new knowledge and skills that these teachers bring to their classrooms and their students. The book is divided into two main parts. Part 1 deals with the difficult to define process of retaining early career teachers, and its respective chapters consider this broad issue from an international perspective. They explore how policies and practices have an impact on what happens in schools, and what it means to be a teacher and to teach. In turn, Part 2 focuses on the need to reconsider the policies and practices that create the 'problem' of early career teachers, and offers alternative ways forward. Each chapter addresses a specific aspect of the early career teacher retention issue, contributing to a greater understanding of how we can rethink the work of early career teachers so that they can more successfully transition into the profession.

Dieses Buch bietet einen Uberblick uber die historische Entwicklung und die Besonderheiten der Krankenhauspolitik in der Bundesrepublik Deutschland. Es werden die wichtigsten Reformen und deren wesentliche Inhalte dargestellt. Die Untersuchung reicht von der ersten Pflegesatzverordnung von 1954 uber das Krankenhausfinanzierungsgesetz von 1972, die verschiedenen Kostendampfungsgesetze der 70er und 80er Jahre bis zur 'Dritten Stufe' der Gesundheitsreform in den Jahren 1995 bis 1998. Der Schwerpunkt der Untersuchung liegt auf der Analyse der Reform der Krankenhausfinanzierung im Rahmen des Gesundheitsstrukturgesetzes 1993. Am Beispiel dieser Reform wird exemplarisch die besondere Bedeutung institutioneller Strukturen und des politischen Prozesses fur die Inhalte krankenhauspolitischer Reformen herausgearbeitet."

Document the architecture of your software easily with this highly practical, open-source template. Key Features Get to grips with leveraging the features of arc42 to create insightful documents Learn the concepts of software architecture documentation through real-world examples Discover techniques to create compact, helpful, and easy-to-read documentation Book DescriptionWhen developers document the architecture of their systems, they often invent their own specific ways of articulating structures, designs, concepts, and decisions. What they need is a template that enables simple and efficient software architecture documentation. arc42 by Example shows how it's done through several real-world examples. Each example in the book, whether it is a chess engine, a huge CRM system, or a cool web system, starts with a brief description of the problem domain and the quality requirements. Then, you'll discover the system context with all the external interfaces. You'll dive into an overview of the solution strategy to implement the building blocks and runtime scenarios. The later chapters also explain various cross-cutting concerns and how they affect other aspects of a program. What you will learn Utilize arc42 to document a system's physical infrastructure Learn how to identify a system's scope and boundaries Break a system down into building blocks and illustrate the relationships between them Discover how to describe the runtime behavior of a system Know how to document design decisions and their reasons Explore the risks and technical debt of your system Who this book is forThis book is for software developers and solutions architects who are looking for an easy, open-source tool to document their systems. It is a useful reference for those who are already using arc42. If you are new to arc42, this book is a great learning resource. For those of you who want to write better technical documentation will benefit from the general concepts covered in this book.

The story is set in a remote castle in thirteenth century France and revolves around the dark passions aroused by Blanche, the beautiful young wife of the Baron who owns the castle. When a young Knight comes to stay with them, the guest overstays his welcome and begins a doomed affair with Blanche.

Who's flying your plane? Do you know who you are and where you're going? Everyone needs courage and hope. Everyone experiences wobbly moments of faith. Everyone needs to make the next move that changes everything--that changes the future. "Altitude" will fly you over eight moves that will change the trajectory of your life. "Altitude's" theme is Your Next Move Changes Everything. The chapters reflect what every person struggles with: how to craft a life of meaning and purpose. "Altitude" is written by teaching pastor Michael Simone, using successful sermons and teachings. Combined with his poignant letters God and the study guide, "Altitude" will apply transformational moves to help individuals and church groups.

Twenty-five, Chinese-American, and agoraphobic, Marcy Chen navigates love, sex, gourmet food, family and a desperate fear of people and intimacy. Living in the trendy Fremont district of Seattle, Washington, Marcy has created a life insulated from the people around her. Slowly she realizes that she must make a choice between seclusion and safety, or living the life she wants - in fear.