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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Fibroblast Growth Factors: Biology And Clinical Application - Fgf Biology And Therapeutics (Hardcover)
Loot Price: R3,540
Discovery Miles 35 400
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Fibroblast Growth Factors: Biology And Clinical Application - Fgf Biology And Therapeutics (Hardcover)
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The fibroblast growth factor (FGF) family of ligands and the
corresponding family of FGF receptor tyrosine kinases comprise one
of the most versatile and diverse growth factor signaling families
in vertebrates, found virtually in every tissue and cell type where
they regulate metabolic and physiologic function, maintain tissue
homeostasis, and mediate injury response, tissue repair, and
regeneration. As a result, FGFs play critical roles in a wide
variety of normal biological and abnormalities in FGF signaling can
lead to a variety of disease states from developmental
malformations, to atherosclerosis, pulmonary hypertension and
cancer among many others. A thorough understanding of this system
is necessary for critical insights into both normal and disease
biology and is essential to development of rationale therapeutic
strategies aimed at treatment of FGF-dependent diseases
states.Recent years have seen advances in our understanding of FGFs
role in endothelial and, more general, vascular biology, the
subject of this book. In particular, FGFs have been implicated in
the maintenance of vascular homeostasis and control of blood vessel
permeability while aberrant FGF signaling has been shown to be
central to the development of pulmonary hypertension, and
endothelial-to-mesenchymal transition, a process implicated in the
development of atherosclerosis. Finally, FGFs ability to stimulate
blood vessel growth has been explored in therapeutic angiogenesis
approaches.With this in mind, the present monograph is structured
to provide comprehensive information to a reader interested in FGFs
in general and vascular biology in particular. To this end, we
explore everything from the structure and signaling of FGFs and
their receptors (Chapters 1, 2 and 3) to their role in the
regulation of vascular homeostasis (Chapter 4) and cardiovascular
diseases (Chapters 5 and 6). We then address new developments in
FGF therapeutics (chapter 7) and explore FGF biology in the
epithelium (Chapter 8) thereby providing a complete analysis of
this growth factor family biology in two closely related but
distinctly different environments - endothelium and epithelium.
Finally, we examine FGF biology in eye disease and in cancer.It is
our hope that this comprehensive treatment of FGF vascular biology
and its application will provide the reader with the accurate and
timely summary of this rapidly moving field.
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