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Left Out (Hardcover, 2nd ed.)
Mike Ludwig; Illustrated by Haeun Sung; Edited by Katharine Worthington
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R524
R441
Discovery Miles 4 410
Save R83 (16%)
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The transmission of the nervous impulse is always from the
dendritic branches and the cell body to the axon or functional
process. Every neuron, then, possesses a receptor apparatus, the
body and the dendritic prolongations, an apparatus of emission, the
axon, and the apparatus of distribution, the terminal arborization
of the nerve fibers. I designated the foregoing principle: the
theory of dynamic polarization (Cajal 1923). Ever since the
beautiful drawings from Golgi and Cajal, we have been familiar with
the organisation of neurones into dendritic, somatic and axonal
compartments. Cajal proposed that these cellular compartments were
specialised, resulting in his concept of ^dynamic polarisation'. He
considered dendrites to be passive elements that simply transferred
information from inputs to the soma. Since the discovery that
dendrites of many neural populations release neuroactive substances
and in doing so, alter neuronal output, it is now apparent that
this theory requires qualification. This book presents recent
developments in the neurophysiology of dendritic release of several
chemical classes of transmitters in a number of different areas of
the mammalian central nervous system. Once released from a neuron,
these substances can act as neurotransmitters and/or
neuromodulators, to autoregulate the original neuron, its synaptic
inputs, and adjacent cells or, by volume transmission, to affect
distant cells. In some systems, dendritic transmitter release is
part independent of secretion from axon terminal signifying a
selective control of the dendritic compartment.
The transmission of the nervous impulse is always from the
dendritic branches and the cell body to the axon or functional
process. Every neuron, then, possesses a receptor apparatus, the
body and the dendritic prolongations, an apparatus of emission, the
axon, and the apparatus of distribution, the terminal arborization
of the nerve fibers. I designated the foregoing principle: the
theory of dynamic polarization (Cajal 1923). Ever since the
beautiful drawings from Golgi and Cajal, we have been familiar with
the organisation of neurones into dendritic, somatic and axonal
compartments. Cajal proposed that these cellular compartments were
specialised, resulting in his concept of ^dynamic polarisation'. He
considered dendrites to be passive elements that simply transferred
information from inputs to the soma. Since the discovery that
dendrites of many neural populations release neuroactive substances
and in doing so, alter neuronal output, it is now apparent that
this theory requires qualification. This book presents recent
developments in the neurophysiology of dendritic release of several
chemical classes of transmitters in a number of different areas of
the mammalian central nervous system. Once released from a neuron,
these substances can act as neurotransmitters and/or
neuromodulators, to autoregulate the original neuron, its synaptic
inputs, and adjacent cells or, by volume transmission, to affect
distant cells. In some systems, dendritic transmitter release is
part independent of secretion from axon terminal signifying a
selective control of the dendritic compartment.
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